-
3
-
-
0022372670
-
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia
-
Saiki R.K., Scharf S., Faloona F., Mullis K.B., Horn G.T., Erlich H.A., et al. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230 (1985) 1350-1354
-
(1985)
Science
, vol.230
, pp. 1350-1354
-
-
Saiki, R.K.1
Scharf, S.2
Faloona, F.3
Mullis, K.B.4
Horn, G.T.5
Erlich, H.A.6
-
4
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
International Human Genome Mapping Consortium
-
International Human Genome Mapping Consortium. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
-
5
-
-
35348983887
-
A second generation human haplotype map of over 3.1 million SNPs
-
International HapMap Consortium
-
International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 449 (2007) 851-861
-
(2007)
Nature
, vol.449
, pp. 851-861
-
-
-
6
-
-
84888485337
-
-
Online Mendelian Inheritance in Man. Disponible en
-
Online Mendelian Inheritance in Man. Disponible en: www.ncbi.nlm.nih.gov/sites/entrez?db=omim
-
-
-
-
7
-
-
10744233618
-
Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
-
International Panel on Management of Familial Hypercholesterolemia
-
Civeira F., and International Panel on Management of Familial Hypercholesterolemia. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis 173 (2004) 55-68
-
(2004)
Atherosclerosis
, vol.173
, pp. 55-68
-
-
Civeira, F.1
-
8
-
-
36048981858
-
Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function
-
Lehnart S.E., Ackerman M.J., Benson Jr. D.W., Brugada R., Clancy C.E., Donahue J.K., et al. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation 116 (2007) 2325-2345
-
(2007)
Circulation
, vol.116
, pp. 2325-2345
-
-
Lehnart, S.E.1
Ackerman, M.J.2
Benson Jr., D.W.3
Brugada, R.4
Clancy, C.E.5
Donahue, J.K.6
-
9
-
-
35548997132
-
Role of genetic analysis in the management of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy
-
Sen-Chowdhry S., Syrris P., and McKenna W.J. Role of genetic analysis in the management of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 50 (2007) 1813-1821
-
(2007)
J Am Coll Cardiol
, vol.50
, pp. 1813-1821
-
-
Sen-Chowdhry, S.1
Syrris, P.2
McKenna, W.J.3
-
10
-
-
44449171454
-
Factores de riesgo cardiovascular. Perspectivas derivadas del Framingham Heart Study
-
O'Donnel C.J., and Elosua R. Factores de riesgo cardiovascular. Perspectivas derivadas del Framingham Heart Study. Rev Esp Cardiol 61 (2008) 299-310
-
(2008)
Rev Esp Cardiol
, vol.61
, pp. 299-310
-
-
O'Donnel, C.J.1
Elosua, R.2
-
11
-
-
0031001720
-
Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study
-
Murray C.J.L., and Lopez A.D. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 349 (1997) 1498-1504
-
(1997)
Lancet
, vol.349
, pp. 1498-1504
-
-
Murray, C.J.L.1
Lopez, A.D.2
-
12
-
-
84888486247
-
-
Instituto Nacional de Estadística. Tablas de mortalidad de la población de España por Comunidades autónomas, Sexo, Edades, Años y Funciones [citado 30 Ene 2009]. Disponible en: http://www.ine.es/jaxi/menu.do?type=pcaxis&path=%2Ft 20%2Fp319a%2F1992-2005&file=pcaxis&N=&L=0
-
Instituto Nacional de Estadística. Tablas de mortalidad de la población de España por Comunidades autónomas, Sexo, Edades, Años y Funciones [citado 30 Ene 2009]. Disponible en: http://www.ine.es/jaxi/menu.do?type=pcaxis&path=%2Ft 20%2Fp319a%2F1992-2005&file=pcaxis&N=&L=0
-
-
-
-
13
-
-
0036259101
-
Epidemiología de la cardiopatía isquémica en España: estimación del número de casos y de las tendencias entre 1997 y 2005
-
Marrugat J., Elosua R., and Marti H. Epidemiología de la cardiopatía isquémica en España: estimación del número de casos y de las tendencias entre 1997 y 2005. Rev Esp Cardiol 55 (2002) 337-346
-
(2002)
Rev Esp Cardiol
, vol.55
, pp. 337-346
-
-
Marrugat, J.1
Elosua, R.2
Marti, H.3
-
14
-
-
67649552647
-
The genes, the heart and destiny
-
White P.D. The genes, the heart and destiny. N Engl J Med 256 (1957) 965-969
-
(1957)
N Engl J Med
, vol.256
, pp. 965-969
-
-
White, P.D.1
-
15
-
-
33846603166
-
Genetics and heritability of coronary artery disease and myocardial infarction
-
Mayer B., Erdmann J., and Schunkert H. Genetics and heritability of coronary artery disease and myocardial infarction. Clin Res Cardiol 96 (2007) 1-7
-
(2007)
Clin Res Cardiol
, vol.96
, pp. 1-7
-
-
Mayer, B.1
Erdmann, J.2
Schunkert, H.3
-
16
-
-
0001866826
-
Familial ocurrence of hypertension and coronary artery disease, with observations concerning obesity and diabetes
-
Thomas C.B., and Cohen H.B. Familial ocurrence of hypertension and coronary artery disease, with observations concerning obesity and diabetes. Ann Int Med 42 (1955) 90-127
-
(1955)
Ann Int Med
, vol.42
, pp. 90-127
-
-
Thomas, C.B.1
Cohen, H.B.2
-
17
-
-
2342486731
-
Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring
-
Lloyd-Jones D.M., Nam B.H., D'Agostino Sr. R.B., Levy D., Murabito J.M., Wang T.J., et al. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA 291 (2004) 2204-2211
-
(2004)
JAMA
, vol.291
, pp. 2204-2211
-
-
Lloyd-Jones, D.M.1
Nam, B.H.2
D'Agostino Sr., R.B.3
Levy, D.4
Murabito, J.M.5
Wang, T.J.6
-
18
-
-
29544440820
-
Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults
-
Murabito J.M., Pencina M.J., Nam B.H., D'Agostino Sr. R.B., Wang T.J., Lloyd-Jones D., et al. Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. JAMA 294 (2005) 3117-3123
-
(2005)
JAMA
, vol.294
, pp. 3117-3123
-
-
Murabito, J.M.1
Pencina, M.J.2
Nam, B.H.3
D'Agostino Sr., R.B.4
Wang, T.J.5
Lloyd-Jones, D.6
-
19
-
-
0028330005
-
Genetic susceptibility to death from coronary heart disease in a study of twins
-
Marenberg M.E., Risch N., Berkman L.F., et al. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330 (1994) 1041-1046
-
(1994)
N Engl J Med
, vol.330
, pp. 1041-1046
-
-
Marenberg, M.E.1
Risch, N.2
Berkman, L.F.3
-
20
-
-
0013921021
-
Familial aggregation of factors associated with coronary heart disease
-
Deutscher S., Sepstein F.H., and Kjelsberg M.O. Familial aggregation of factors associated with coronary heart disease. Circulation 33 (1966) 911-924
-
(1966)
Circulation
, vol.33
, pp. 911-924
-
-
Deutscher, S.1
Sepstein, F.H.2
Kjelsberg, M.O.3
-
21
-
-
0018901060
-
Genetic-epidemiologic study of early-onset ischemic heart disease
-
Nora J.J., Lortscher R.H., Spangler R.D., Nora A.H., and Kimberling W.J. Genetic-epidemiologic study of early-onset ischemic heart disease. Circulation 61 (1980) 503-508
-
(1980)
Circulation
, vol.61
, pp. 503-508
-
-
Nora, J.J.1
Lortscher, R.H.2
Spangler, R.D.3
Nora, A.H.4
Kimberling, W.J.5
-
22
-
-
0036378360
-
Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins
-
Zdravkovic S., Wienke A., Pedersen N.L., Marenberg M.E., Yashin A.I., and De Faire U. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. J Intern Med 252 (2002) 247-254
-
(2002)
J Intern Med
, vol.252
, pp. 247-254
-
-
Zdravkovic, S.1
Wienke, A.2
Pedersen, N.L.3
Marenberg, M.E.4
Yashin, A.I.5
De Faire, U.6
-
23
-
-
0035714243
-
The heritability of mortality due to heart diseases: a correlated frailty model applied to Danish twins
-
Wienke A., Holm N.V., Skytthe A., and Yashin A.I. The heritability of mortality due to heart diseases: a correlated frailty model applied to Danish twins. Twin Res 4 (2001) 266-274
-
(2001)
Twin Res
, vol.4
, pp. 266-274
-
-
Wienke, A.1
Holm, N.V.2
Skytthe, A.3
Yashin, A.I.4
-
24
-
-
0037118704
-
Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults
-
Peyser P.A., Bielak L.F., Chu J.S., Turner S.T., Ellsworth D.L., Boerwinkle E., et al. Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults. Circulation 106 (2002) 304-308
-
(2002)
Circulation
, vol.106
, pp. 304-308
-
-
Peyser, P.A.1
Bielak, L.F.2
Chu, J.S.3
Turner, S.T.4
Ellsworth, D.L.5
Boerwinkle, E.6
-
25
-
-
0036091537
-
Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent
-
Xiang A.H., Azen S.P., Buchanan T.A., Raffel L.J., Tan S., Cheng L.S., et al. Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent. Arterioscler Thromb Vasc Biol 22 (2002) 843-848
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 843-848
-
-
Xiang, A.H.1
Azen, S.P.2
Buchanan, T.A.3
Raffel, L.J.4
Tan, S.5
Cheng, L.S.6
-
26
-
-
0037319447
-
Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study
-
Fox C.S., Polak J.F., Chazaro I., Cupples A., Wolf P.A., D'Agostino R.A., et al. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke 34 (2003) 397-401
-
(2003)
Stroke
, vol.34
, pp. 397-401
-
-
Fox, C.S.1
Polak, J.F.2
Chazaro, I.3
Cupples, A.4
Wolf, P.A.5
D'Agostino, R.A.6
-
27
-
-
4744362880
-
Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study
-
Juo S.H., Lin H.F., Rundek T., Sabala E.A., Boden-Albala B., Park N., et al. Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study. Stroke 35 (2004) 2243-2247
-
(2004)
Stroke
, vol.35
, pp. 2243-2247
-
-
Juo, S.H.1
Lin, H.F.2
Rundek, T.3
Sabala, E.A.4
Boden-Albala, B.5
Park, N.6
-
28
-
-
0037212367
-
The determination of carotid intima medial thickness in adults-a population-based twin study
-
Swan L., Birnie D.H., Inglis G., Connell J.M., and Hillis W.S. The determination of carotid intima medial thickness in adults-a population-based twin study. Atherosclerosis 166 (2003) 137-141
-
(2003)
Atherosclerosis
, vol.166
, pp. 137-141
-
-
Swan, L.1
Birnie, D.H.2
Inglis, G.3
Connell, J.M.4
Hillis, W.S.5
-
29
-
-
0036791559
-
Heritability of carotid artery structure and function: the Strong Heart Family Study
-
North K.E., MacCluer J.W., Devereux R.B., Howard B.V., Welty T.K., Best L.G., et al. Heritability of carotid artery structure and function: the Strong Heart Family Study. Arterioscler Thromb Vasc Biol 22 (2002) 1698-1703
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 1698-1703
-
-
North, K.E.1
MacCluer, J.W.2
Devereux, R.B.3
Howard, B.V.4
Welty, T.K.5
Best, L.G.6
-
30
-
-
0036903156
-
Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study
-
Hunt K.J., Duggirala R., Göring H.H., Williams J.T., Almasy L., Blangero J., et al. Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study. Stroke 33 (2002) 2775-2780
-
(2002)
Stroke
, vol.33
, pp. 2775-2780
-
-
Hunt, K.J.1
Duggirala, R.2
Göring, H.H.3
Williams, J.T.4
Almasy, L.5
Blangero, J.6
-
31
-
-
33645301894
-
Role of genetic analyses in cardiology. Part II: Heritability estimation for gene searching in multifactorial diseases
-
Van Asselt K.M., Kok H.S., Van der Schouw Y.T., Peeters P.H.M., Pearson P.L., and Grobbee D.E. Role of genetic analyses in cardiology. Part II: Heritability estimation for gene searching in multifactorial diseases. Circulation 113 (2006) 1136-1139
-
(2006)
Circulation
, vol.113
, pp. 1136-1139
-
-
Van Asselt, K.M.1
Kok, H.S.2
Van der Schouw, Y.T.3
Peeters, P.H.M.4
Pearson, P.L.5
Grobbee, D.E.6
-
32
-
-
0023663060
-
A genetic linkage map of the human genome
-
Donis-Keller H., Green P., Helms C., Cartinhour S., Weiffenbach B., Stephens K., et al. A genetic linkage map of the human genome. Cell 51 (1987) 319
-
(1987)
Cell
, vol.51
, pp. 319
-
-
Donis-Keller, H.1
Green, P.2
Helms, C.3
Cartinhour, S.4
Weiffenbach, B.5
Stephens, K.6
-
33
-
-
0021028244
-
A polymorphic DNA marker genetically linked to Huntington's disease
-
Gusella J.F., Wexler N.S., Conneally P.M., Naylor S.L., Anderson M.A., Tanzi R.E., et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306 (1983) 234
-
(1983)
Nature
, vol.306
, pp. 234
-
-
Gusella, J.F.1
Wexler, N.S.2
Conneally, P.M.3
Naylor, S.L.4
Anderson, M.A.5
Tanzi, R.E.6
-
34
-
-
20544467972
-
Identifying novel genes for atherosclerosis through mousehuman comparative genetics
-
Wang X., Ishimori N., Korstanje R., Rollins J., and Paigen B. Identifying novel genes for atherosclerosis through mousehuman comparative genetics. Am J Hum Genet 77 (2005) 1-15
-
(2005)
Am J Hum Genet
, vol.77
, pp. 1-15
-
-
Wang, X.1
Ishimori, N.2
Korstanje, R.3
Rollins, J.4
Paigen, B.5
-
35
-
-
0033658950
-
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland
-
Pajukanta P., Cargill M., Viitanen L., Nuotio I., Kareinen A., Perola M., et al. Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet 67 (2000) 1481-1493
-
(2000)
Am J Hum Genet
, vol.67
, pp. 1481-1493
-
-
Pajukanta, P.1
Cargill, M.2
Viitanen, L.3
Nuotio, I.4
Kareinen, A.5
Perola, M.6
-
36
-
-
18244398717
-
A Genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27
-
Francke S., Manraj M., Lacquemant C., Lecoeur C., Leprêtre F., Passa P., et al. A Genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum Mol Genet 10 (2001) 2751-2765
-
(2001)
Hum Mol Genet
, vol.10
, pp. 2751-2765
-
-
Francke, S.1
Manraj, M.2
Lacquemant, C.3
Lecoeur, C.4
Leprêtre, F.5
Passa, P.6
-
37
-
-
18544372620
-
A comprehensive linkage analysis for myocardial infarction and its related risk factors
-
Broeckel U., Hengstenberg C., Mayer B., Holmer S., Martin L.J., Comuzzie A.G., et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 30 (2002) 210-214
-
(2002)
Nat Genet
, vol.30
, pp. 210-214
-
-
Broeckel, U.1
Hengstenberg, C.2
Mayer, B.3
Holmer, S.4
Martin, L.J.5
Comuzzie, A.G.6
-
38
-
-
0344827206
-
Mutation of MEF2A in an inherited disorder with features of coronary artery disease
-
Wang L. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science 302 (2003) 1578-1581
-
(2003)
Science
, vol.302
, pp. 1578-1581
-
-
Wang, L.1
-
39
-
-
10744233196
-
Premature myocardial infarction novel susceptibility locus on chromosome 1p34-36 identified by genomewide linkage analysis
-
Wang Q., Rao S., Shen G.Q., Li L., Moliterno D.J., Newby L.K., et al. Premature myocardial infarction novel susceptibility locus on chromosome 1p34-36 identified by genomewide linkage analysis. Am J Hum Genet 74 (2004) 262-271
-
(2004)
Am J Hum Genet
, vol.74
, pp. 262-271
-
-
Wang, Q.1
Rao, S.2
Shen, G.Q.3
Li, L.4
Moliterno, D.J.5
Newby, L.K.6
-
40
-
-
4143098058
-
A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
-
Hauser E.R., Crossman D.C., Granger C.B., Haines J.L., Jones C.J., Mooser V., et al. A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. Am J Hum Genet 75 (2004) 436-447
-
(2004)
Am J Hum Genet
, vol.75
, pp. 436-447
-
-
Hauser, E.R.1
Crossman, D.C.2
Granger, C.B.3
Haines, J.L.4
Jones, C.J.5
Mooser, V.6
-
41
-
-
10744220794
-
The gene encoding 5-lipoxiygenase activating protein confers risk of myocardial infarction and stroke
-
Helgadottir A., Manolescu A., Thorleifsson G., Gretarsdottir S., Jonsdottir H., Thorsteinsdottir U., et al. The gene encoding 5-lipoxiygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 36 (2004) 233-239
-
(2004)
Nat Genet
, vol.36
, pp. 233-239
-
-
Helgadottir, A.1
Manolescu, A.2
Thorleifsson, G.3
Gretarsdottir, S.4
Jonsdottir, H.5
Thorsteinsdottir, U.6
-
42
-
-
28144451633
-
A genomewide linkage study of 1933 families affected by premature coronary artery disease: the British Heart Foundation (BHF) Family Heart Study
-
BHF Family Heart Study Research Group
-
BHF Family Heart Study Research Group. A genomewide linkage study of 1933 families affected by premature coronary artery disease: the British Heart Foundation (BHF) Family Heart Study. Am J Hum Genet 77 (2005) 1011-1020
-
(2005)
Am J Hum Genet
, vol.77
, pp. 1011-1020
-
-
-
43
-
-
32944473313
-
The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction
-
González P., García-Castro M., Reguero J.R., Batalla A., Ordóñez A.G., Palop R.L., et al. The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction. J Med Genet 43 (2006) 167-169
-
(2006)
J Med Genet
, vol.43
, pp. 167-169
-
-
González, P.1
García-Castro, M.2
Reguero, J.R.3
Batalla, A.4
Ordóñez, A.G.5
Palop, R.L.6
-
44
-
-
16844368100
-
Lack of MEF2A mutations in coronary artery disease
-
Weng L., Kavaslar N., Ustaszewska A., Doelle H., Schackwitz W., Hébert S., et al. Lack of MEF2A mutations in coronary artery disease. J Clin Invest 115 (2005) 1016-1020
-
(2005)
J Clin Invest
, vol.115
, pp. 1016-1020
-
-
Weng, L.1
Kavaslar, N.2
Ustaszewska, A.3
Doelle, H.4
Schackwitz, W.5
Hébert, S.6
-
45
-
-
38049144096
-
Lack of association between the MEF2A gene and myocardial infarction
-
Lieb W., Mayer B., König I.R., Borwitzky I., Götz A., Kain S., et al. Lack of association between the MEF2A gene and myocardial infarction. Circulation 117 (2008) 185-191
-
(2008)
Circulation
, vol.117
, pp. 185-191
-
-
Lieb, W.1
Mayer, B.2
König, I.R.3
Borwitzky, I.4
Götz, A.5
Kain, S.6
-
46
-
-
16844382494
-
MEF2A sequence variants and coronary artery disease: a change of heart?
-
Altshuler D., and Hirschhorn J.N. MEF2A sequence variants and coronary artery disease: a change of heart?. J Clin Invest 115 (2005) 831-833
-
(2005)
J Clin Invest
, vol.115
, pp. 831-833
-
-
Altshuler, D.1
Hirschhorn, J.N.2
-
47
-
-
13844289142
-
Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population
-
Helgadottir A., Gretarsdottir S., St Clair D., Manolescu A., Cheung J., Thorleifsson G., et al. Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Am J Hum Genet 76 (2005) 505-509
-
(2005)
Am J Hum Genet
, vol.76
, pp. 505-509
-
-
Helgadottir, A.1
Gretarsdottir, S.2
St Clair, D.3
Manolescu, A.4
Cheung, J.5
Thorleifsson, G.6
-
48
-
-
34248209061
-
Association of ALOX5AP with ischemic stroke: a population-based case-control study
-
Kaushal R., Pal P., Alwell K., Haverbusch M., Flaherty M., Moomaw C., et al. Association of ALOX5AP with ischemic stroke: a population-based case-control study. Hum Genet 121 (2007) 601-607
-
(2007)
Hum Genet
, vol.121
, pp. 601-607
-
-
Kaushal, R.1
Pal, P.2
Alwell, K.3
Haverbusch, M.4
Flaherty, M.5
Moomaw, C.6
-
49
-
-
33747183983
-
Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach
-
Zee R.Y., Cheng S., Hegener H.H., Erlich H.A., and Ridker P.M. Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. Stroke 37 (2006) 2007-2011
-
(2006)
Stroke
, vol.37
, pp. 2007-2011
-
-
Zee, R.Y.1
Cheng, S.2
Hegener, H.H.3
Erlich, H.A.4
Ridker, P.M.5
-
50
-
-
0037178728
-
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
-
Meharabian M., Allayee H., Wong J., et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 91 (2002) 120-126
-
(2002)
Circ Res
, vol.91
, pp. 120-126
-
-
Meharabian, M.1
Allayee, H.2
Wong, J.3
-
51
-
-
18244403498
-
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial
-
Hakonarson H., Thorvaldsson S., Helgadottir A., et al. Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial. JAMA 293 (2005) 2245-2256
-
(2005)
JAMA
, vol.293
, pp. 2245-2256
-
-
Hakonarson, H.1
Thorvaldsson, S.2
Helgadottir, A.3
-
52
-
-
70350557123
-
Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines
-
Schulze T.G., and McMahon F.J. Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am J Med Genet 114 (2002) 1-11
-
(2002)
Am J Med Genet
, vol.114
, pp. 1-11
-
-
Schulze, T.G.1
McMahon, F.J.2
-
53
-
-
84924835495
-
The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration
-
Aird I., Bentall H.H., Mehigan J.A., and Roberts J.A. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J 2 (1954) 315-321
-
(1954)
Br Med J
, vol.2
, pp. 315-321
-
-
Aird, I.1
Bentall, H.H.2
Mehigan, J.A.3
Roberts, J.A.4
-
54
-
-
58149387637
-
How to use an article about genetic association. A: Background concepts
-
Attia J., Ioannidis J.P., Thakkinstian A., McEvoy M., Scott R.J., Minelli C., et al. How to use an article about genetic association. A: Background concepts. JAMA 301 (2009) 74-81
-
(2009)
JAMA
, vol.301
, pp. 74-81
-
-
Attia, J.1
Ioannidis, J.P.2
Thakkinstian, A.3
McEvoy, M.4
Scott, R.J.5
Minelli, C.6
-
55
-
-
58249089746
-
How to use an article about genetic association: B: Are the results of the study valid?
-
Attia J., Ioannidis J.P., Thakkinstian A., McEvoy M., Scott R.J., Minelli C., et al. How to use an article about genetic association: B: Are the results of the study valid?. JAMA 301 (2009) 191-197
-
(2009)
JAMA
, vol.301
, pp. 191-197
-
-
Attia, J.1
Ioannidis, J.P.2
Thakkinstian, A.3
McEvoy, M.4
Scott, R.J.5
Minelli, C.6
-
56
-
-
58749099119
-
How to use an article about genetic association: C: What are the results and will they help me in caring for my patients?
-
Attia J., Ioannidis J.P., Thakkinstian A., McEvoy M., Scott R.J., Minelli C., et al. How to use an article about genetic association: C: What are the results and will they help me in caring for my patients?. JAMA 301 (2009) 304-308
-
(2009)
JAMA
, vol.301
, pp. 304-308
-
-
Attia, J.1
Ioannidis, J.P.2
Thakkinstian, A.3
McEvoy, M.4
Scott, R.J.5
Minelli, C.6
-
58
-
-
34548736492
-
Association of apolipoprotein E genotypes with lipid levels and coronary risk
-
Bennet A.M., Di Angelantonio E., Ye Z., Wensley F., Dahlin A., Ahlbom A., et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 298 (2007) 1300-1311
-
(2007)
JAMA
, vol.298
, pp. 1300-1311
-
-
Bennet, A.M.1
Di Angelantonio, E.2
Ye, Z.3
Wensley, F.4
Dahlin, A.5
Ahlbom, A.6
-
59
-
-
50549104256
-
Why most discovered true associations are inflated
-
Ioannidis J.P. Why most discovered true associations are inflated. Epidemiology 19 (2008) 640-648
-
(2008)
Epidemiology
, vol.19
, pp. 640-648
-
-
Ioannidis, J.P.1
-
60
-
-
33846563409
-
Why most published research findings are false
-
Ioannidis J.P. Why most published research findings are false. PloS Med 2 (2005) e124
-
(2005)
PloS Med
, vol.2
-
-
Ioannidis, J.P.1
-
61
-
-
34249997024
-
NCI-NHGRI Working Group on Replication in Association Studies. Replicating genotype-phenotype associations
-
Chanock S.J., Manolio T., Boehnke M., Boerwinkle E., Hunter D.J., Thomas G., et al. NCI-NHGRI Working Group on Replication in Association Studies. Replicating genotype-phenotype associations. Nature 447 (2007) 655-660
-
(2007)
Nature
, vol.447
, pp. 655-660
-
-
Chanock, S.J.1
Manolio, T.2
Boehnke, M.3
Boerwinkle, E.4
Hunter, D.J.5
Thomas, G.6
-
62
-
-
38949094880
-
Assessment of cumulative evidence on genetic associations: interim guidelines
-
Ioannidis J.P., Boffetta P., Little J., O'Brien T.R., Uitterlinden A.G., Vineis P., et al. Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol 37 (2008) 120-132
-
(2008)
Int J Epidemiol
, vol.37
, pp. 120-132
-
-
Ioannidis, J.P.1
Boffetta, P.2
Little, J.3
O'Brien, T.R.4
Uitterlinden, A.G.5
Vineis, P.6
-
63
-
-
13944265645
-
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
-
Cohen J., Pertsemlidis A., Kotowski I.K., Graham R., Garcia C.K., and Hobbs H.H. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 37 (2005) 161-165
-
(2005)
Nat Genet
, vol.37
, pp. 161-165
-
-
Cohen, J.1
Pertsemlidis, A.2
Kotowski, I.K.3
Graham, R.4
Garcia, C.K.5
Hobbs, H.H.6
-
64
-
-
33344464808
-
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
-
Kotowski I.K., Pertsemlidis A., Luke A., Cooper R.S., Vega G.L., Cohen J.C., et al. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet 78 (2006) 410-422
-
(2006)
Am J Hum Genet
, vol.78
, pp. 410-422
-
-
Kotowski, I.K.1
Pertsemlidis, A.2
Luke, A.3
Cooper, R.S.4
Vega, G.L.5
Cohen, J.C.6
-
65
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen J.C., Boerwinkle E., Mosley Jr. T.H., and Hobbs H.H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 354 (2006) 1264-1272
-
(2006)
N Engl J Med
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley Jr., T.H.3
Hobbs, H.H.4
-
66
-
-
44249122796
-
Myocardial Infarction Genetics Consortium. A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction
-
Kathiresan S. Myocardial Infarction Genetics Consortium. A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. N Engl J Med 358 (2008) 2299-2300
-
(2008)
N Engl J Med
, vol.358
, pp. 2299-2300
-
-
Kathiresan, S.1
-
67
-
-
38649125868
-
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
-
Willer C.J., Sanna S., Jackson A.U., Scuteri A., Bonnycastle L.L., Clarke R., et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40 (2008) 161-169
-
(2008)
Nat Genet
, vol.40
, pp. 161-169
-
-
Willer, C.J.1
Sanna, S.2
Jackson, A.U.3
Scuteri, A.4
Bonnycastle, L.L.5
Clarke, R.6
-
68
-
-
11144355565
-
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
-
Fernández-Fernández J.M., Tomás M., Vázquez E., Orio P., Latorre R., Sentí M., et al. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J Clin Invest 113 (2004) 1032-1039
-
(2004)
J Clin Invest
, vol.113
, pp. 1032-1039
-
-
Fernández-Fernández, J.M.1
Tomás, M.2
Vázquez, E.3
Orio, P.4
Latorre, R.5
Sentí, M.6
-
69
-
-
33644687241
-
Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk
-
Sentí M., Fernández-Fernández J.M., Tomás M., Vázquez E., Elosua R., Marrugat J., et al. Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Circ Res 97 (2005) 1360-1365
-
(2005)
Circ Res
, vol.97
, pp. 1360-1365
-
-
Sentí, M.1
Fernández-Fernández, J.M.2
Tomás, M.3
Vázquez, E.4
Elosua, R.5
Marrugat, J.6
-
70
-
-
44449087808
-
Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population
-
Zhao Q., Wang L., Yang W., Chen S., Huang J., Fan Z., et al. Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population. Pharmacogenet Genomics 18 (2008) 459-466
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 459-466
-
-
Zhao, Q.1
Wang, L.2
Yang, W.3
Chen, S.4
Huang, J.5
Fan, Z.6
-
71
-
-
56049114003
-
The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes
-
Nielsen T., Burgdorf K.S., Grarup N., Borch-Johnsen K., Hansen T., Jørgensen T., et al. The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes. J Hypertens 26 (2008) 2142-2146
-
(2008)
J Hypertens
, vol.26
, pp. 2142-2146
-
-
Nielsen, T.1
Burgdorf, K.S.2
Grarup, N.3
Borch-Johnsen, K.4
Hansen, T.5
Jørgensen, T.6
-
72
-
-
34547919927
-
INVEST Investigators KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)
-
Beitelshees A.L., Gong Y., Wang D., Schork N.J., Cooper-Dehoff R.M., Langaee T.Y., et al. INVEST Investigators KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST). Pharmacogenet Genomics 17 (2007) 719-729
-
(2007)
Pharmacogenet Genomics
, vol.17
, pp. 719-729
-
-
Beitelshees, A.L.1
Gong, Y.2
Wang, D.3
Schork, N.J.4
Cooper-Dehoff, R.M.5
Langaee, T.Y.6
-
73
-
-
45849116481
-
The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade
-
Kelley-Hedgepeth A., Peter I., Kip K., Montefusco M., Kogan S., Cox D., et al. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. J Hum Hypertens 22 (2008) 512-515
-
(2008)
J Hum Hypertens
, vol.22
, pp. 512-515
-
-
Kelley-Hedgepeth, A.1
Peter, I.2
Kip, K.3
Montefusco, M.4
Kogan, S.5
Cox, D.6
-
74
-
-
0029805706
-
The new genomics: global views of biology
-
Lander E.S. The new genomics: global views of biology. Science 274 (1996) 536-539
-
(1996)
Science
, vol.274
, pp. 536-539
-
-
Lander, E.S.1
-
75
-
-
84888513370
-
-
Disponible en
-
Entrez SNP. Disponible en: www.ncbi.nlm.nih.gov/sites/entrez?db=snp
-
-
-
Entrez, S.N.P.1
-
76
-
-
43049146524
-
A HapMap harvest of insights into the genetics of common disease
-
Manolio T.A., Brooks L.D., and Collins F.S. A HapMap harvest of insights into the genetics of common disease. J Clin Invest 118 (2008) 1590-1605
-
(2008)
J Clin Invest
, vol.118
, pp. 1590-1605
-
-
Manolio, T.A.1
Brooks, L.D.2
Collins, F.S.3
-
77
-
-
34250010480
-
A common variant on chromosome 9p21 affects the risk of myocardial infarction
-
Helgadottir A., Thorleifsson G., Manolescu A., Gretarsdottir S., Blondal T., Jonasdottir A., et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316 (2007) 1491-1493
-
(2007)
Science
, vol.316
, pp. 1491-1493
-
-
Helgadottir, A.1
Thorleifsson, G.2
Manolescu, A.3
Gretarsdottir, S.4
Blondal, T.5
Jonasdottir, A.6
-
78
-
-
34249996115
-
A common allele on chromosome 9 associated with coronary heart disease
-
McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R., et al. A common allele on chromosome 9 associated with coronary heart disease. Science 316 (2007) 1488-1491
-
(2007)
Science
, vol.316
, pp. 1488-1491
-
-
McPherson, R.1
Pertsemlidis, A.2
Kavaslar, N.3
Stewart, A.4
Roberts, R.5
Cox, D.R.6
-
79
-
-
34547623750
-
Genomewide association analysis of coronary artery disease
-
Samani N.J., Erdmann J., Hall A.S., Hengstenberg C., Mangino M., Mayer B., et al. Genomewide association analysis of coronary artery disease. N Engl J Med 357 (2007) 443-453
-
(2007)
N Engl J Med
, vol.357
, pp. 443-453
-
-
Samani, N.J.1
Erdmann, J.2
Hall, A.S.3
Hengstenberg, C.4
Mangino, M.5
Mayer, B.6
-
80
-
-
67649527902
-
Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants
-
Myocardial Infarction Genetics Consortium Feb 8
-
Myocardial Infarction Genetics Consortium. Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants. Nat Genet Epub (2009) Feb 8
-
(2009)
Nat Genet Epub
-
-
-
81
-
-
84888507952
-
Novel susceptibility locus for coronary artery disease on chromosome 3q22.3
-
Feb 8
-
Erdmaan J., Grobhennig A., Braund P.S., Konig I.R., Hengstenberg C., Hall A.S., et al. Novel susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet Epub (2009) Feb 8
-
(2009)
Nat Genet Epub
-
-
Erdmaan, J.1
Grobhennig, A.2
Braund, P.S.3
Konig, I.R.4
Hengstenberg, C.5
Hall, A.S.6
-
82
-
-
61349108698
-
SNPs in BRAP associated with risk of myocardial infarction in Asian populations
-
Feb 8
-
Ozaki K., Sato H., Inoue K., Tsunoda T., Sakata Y., Mizuno H., et al. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nat Genet Epub (2009) Feb 8
-
(2009)
Nat Genet Epub
-
-
Ozaki, K.1
Sato, H.2
Inoue, K.3
Tsunoda, T.4
Sakata, Y.5
Mizuno, H.6
-
83
-
-
84888520540
-
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
-
Feb 8
-
Gudbjasrtsson D.F., Bjornsdottier U.S., Halapir E., Helgadottir A., Sulem P., Jonsdottir G.M., et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet Epub (2009) Feb 8
-
(2009)
Nat Genet Epub
-
-
Gudbjasrtsson, D.F.1
Bjornsdottier, U.S.2
Halapir, E.3
Helgadottir, A.4
Sulem, P.5
Jonsdottir, G.M.6
-
84
-
-
61349137526
-
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
-
Feb 8
-
Tregouet D.A., Konig I.R., Erdmann J., Muteanu A., Braund P.S., Hall A.S., et al. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet Epub (2009) Feb 8
-
(2009)
Nat Genet Epub
-
-
Tregouet, D.A.1
Konig, I.R.2
Erdmann, J.3
Muteanu, A.4
Braund, P.S.5
Hall, A.S.6
-
85
-
-
38649084407
-
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
-
Kooner J.S., Chambers J.C., Aguilar-Salinas C.A., Hinds D.A., Hyde C.L., Warnes G.R., et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 40 (2008) 149-151
-
(2008)
Nat Genet
, vol.40
, pp. 149-151
-
-
Kooner, J.S.1
Chambers, J.C.2
Aguilar-Salinas, C.A.3
Hinds, D.A.4
Hyde, C.L.5
Warnes, G.R.6
-
86
-
-
58149262866
-
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
-
Pollin T.I., Damcott C.M., Shen H., Ott S.H., Shelton J., Horenstein R.B., et al. A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science 322 (2008) 1702-1705
-
(2008)
Science
, vol.322
, pp. 1702-1705
-
-
Pollin, T.I.1
Damcott, C.M.2
Shen, H.3
Ott, S.H.4
Shelton, J.5
Horenstein, R.B.6
-
87
-
-
38749149611
-
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
-
Wallace C., Newhouse S.J., Braund P., Zhang F., Tobin M., Falchi M., et al. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet 82 (2008) 139-149
-
(2008)
Am J Hum Genet
, vol.82
, pp. 139-149
-
-
Wallace, C.1
Newhouse, S.J.2
Braund, P.3
Zhang, F.4
Tobin, M.5
Falchi, M.6
-
88
-
-
38849166666
-
LDL-cholesterol concentrations: a genome-wide association study
-
Sandhu M.S., Waterworth D.M., Debenham S.L., Wheeler E., Papadakis K., Zhao J.H., et al. LDL-cholesterol concentrations: a genome-wide association study. Lancet 371 (2008) 483-491
-
(2008)
Lancet
, vol.371
, pp. 483-491
-
-
Sandhu, M.S.1
Waterworth, D.M.2
Debenham, S.L.3
Wheeler, E.4
Papadakis, K.5
Zhao, J.H.6
-
89
-
-
55449105227
-
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13
-
Burkhardt R., Kenny E.E., Lowe J.K., Birkeland A., Josowitz R., Noel M., et al. Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. Arterioscler Thromb Vasc Biol 28 (2008) 2078-2084
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 2078-2084
-
-
Burkhardt, R.1
Kenny, E.E.2
Lowe, J.K.3
Birkeland, A.4
Josowitz, R.5
Noel, M.6
-
90
-
-
38649125868
-
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
-
Willer C.J., Sanna S., Jackson A.U., Scuteri A., Bonnycastle L.L., Clarke R., et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40 (2008) 161-169
-
(2008)
Nat Genet
, vol.40
, pp. 161-169
-
-
Willer, C.J.1
Sanna, S.2
Jackson, A.U.3
Scuteri, A.4
Bonnycastle, L.L.5
Clarke, R.6
-
91
-
-
38649132270
-
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
-
Kathiresan S., Melander O., Guiducci C., Surti A., Burtt N.P., Rieder M.J., et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40 (2008) 189-197
-
(2008)
Nat Genet
, vol.40
, pp. 189-197
-
-
Kathiresan, S.1
Melander, O.2
Guiducci, C.3
Surti, A.4
Burtt, N.P.5
Rieder, M.J.6
-
92
-
-
58149159573
-
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
-
Sabatti C., Service S.K., Hartikainen A.L., Pouta A., Ripatti S., Brodsky J., et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41 (2009) 35-46
-
(2009)
Nat Genet
, vol.41
, pp. 35-46
-
-
Sabatti, C.1
Service, S.K.2
Hartikainen, A.L.3
Pouta, A.4
Ripatti, S.5
Brodsky, J.6
-
93
-
-
58149163149
-
Common variants at 30 loci contribute to polygenic dyslipidemia
-
Kathiresan S., Willer C.J., Peloso G.M., Demissie S., Musunuru K., Schadt E.E., et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41 (2009) 56-65
-
(2009)
Nat Genet
, vol.41
, pp. 56-65
-
-
Kathiresan, S.1
Willer, C.J.2
Peloso, G.M.3
Demissie, S.4
Musunuru, K.5
Schadt, E.E.6
-
94
-
-
58149161560
-
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
-
Aulchenko Y.S., Ripatti S., Lindqvist I., Boomsma D., Heid I.M., Pramstaller P.P., et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41 (2009) 47-55
-
(2009)
Nat Genet
, vol.41
, pp. 47-55
-
-
Aulchenko, Y.S.1
Ripatti, S.2
Lindqvist, I.3
Boomsma, D.4
Heid, I.M.5
Pramstaller, P.P.6
-
95
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
WTCCC
-
WTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
96
-
-
35748976848
-
Genome-wide association with diabetes-related traits in the Framingham Heart Study
-
Meigs J.B., Manning A.K., Fox C.S., Florez J.C., Liu C., Cupples L.A., et al. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet 8 Suppl 1 (2007) S16
-
(2007)
BMC Med Genet
, vol.8
, Issue.SUPPL. 1
-
-
Meigs, J.B.1
Manning, A.K.2
Fox, C.S.3
Florez, J.C.4
Liu, C.5
Cupples, L.A.6
-
97
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
Zeggini E., Weedon M.N., Lindgren C.M., Frayling T.M., Elliott K.S., Lango H., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 (2007) 1336-1341
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
-
98
-
-
34547755055
-
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium
-
Salonen J.T., Uimari P., Aalto J.M., Pirskanen M., Kaikkonen J., Todorova B., et al. Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet 81 (2007) 338-345
-
(2007)
Am J Hum Genet
, vol.81
, pp. 338-345
-
-
Salonen, J.T.1
Uimari, P.2
Aalto, J.M.3
Pirskanen, M.4
Kaikkonen, J.5
Todorova, B.6
-
99
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Saxena R., Voight B.F., Lyssenko V., Burtt N.P., De Bakker P.I., Chen H., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331-1336
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
De Bakker, P.I.5
Chen, H.6
-
100
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
Steinthorsdottir V., Thorleifsson G., Reynisdottir I., Benediktsson R., Jonsdottir T., Walters G.B., et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39 (2007) 770-775
-
(2007)
Nat Genet
, vol.39
, pp. 770-775
-
-
Steinthorsdottir, V.1
Thorleifsson, G.2
Reynisdottir, I.3
Benediktsson, R.4
Jonsdottir, T.5
Walters, G.B.6
-
101
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
-
Scott L.J., Mohlke K.L., Bonnycastle L.L., Willer C.J., Li Y., Duren W.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 (2007) 1341-1345
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
-
102
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 (2007) 881-885
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
Dina, C.4
Shen, L.5
Serre, D.6
-
103
-
-
63249135474
-
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
-
Timpson N.J., Lindgren C.M., Weedon M.N., Randall J., Ouwehand W.H., Strachan D.P., et al. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data. Diabetes 58 (2009) 505-510
-
(2009)
Diabetes
, vol.58
, pp. 505-510
-
-
Timpson, N.J.1
Lindgren, C.M.2
Weedon, M.N.3
Randall, J.4
Ouwehand, W.H.5
Strachan, D.P.6
-
104
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Zeggini E., Scott L.J., Saxena R., Voight B.F., Marchini J.L., Hu T., et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40 (2008) 638-645
-
(2008)
Nat Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
Marchini, J.L.5
Hu, T.6
-
105
-
-
33846536406
-
Novel genes identified in a high-density genome wide association study for nicotine dependence
-
Bierut L.J., Madden P.A., Breslau N., Johnson E.O., Hatsukami D., Pomerleau O.F., et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 16 (2007) 24-35
-
(2007)
Hum Mol Genet
, vol.16
, pp. 24-35
-
-
Bierut, L.J.1
Madden, P.A.2
Breslau, N.3
Johnson, E.O.4
Hatsukami, D.5
Pomerleau, O.F.6
-
106
-
-
41649103052
-
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
-
Thorgeirsson T.E., Geller F., Sulem P., Rafnar T., Wiste A., Magnusson K.P., et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452 (2008) 638-642
-
(2008)
Nature
, vol.452
, pp. 638-642
-
-
Thorgeirsson, T.E.1
Geller, F.2
Sulem, P.3
Rafnar, T.4
Wiste, A.5
Magnusson, K.P.6
-
107
-
-
35748970488
-
Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
-
Fox C.S., Heard-Costa N., Cupples L.A., Dupuis J., Vasan R.S., and Atwood L.D. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. BMC Med Genet 8 Suppl 1 (2007) S18
-
(2007)
BMC Med Genet
, vol.8
, Issue.SUPPL. 1
-
-
Fox, C.S.1
Heard-Costa, N.2
Cupples, L.A.3
Dupuis, J.4
Vasan, R.S.5
Atwood, L.D.6
-
108
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling T.M., Timpson N.J., Weedon M.N., Zeggini E., Freathy R.M., Lindgren C.M., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316 (2007) 889-894
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
Lindgren, C.M.6
-
109
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri A., Sanna S., Chen W.M., Uda M., Albai G., Strait J., et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3 (2007) e115
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.M.3
Uda, M.4
Albai, G.5
Strait, J.6
-
110
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos R.J., Lindgren C.M., Li S., Wheeler E., Zhao J.H., Prokopenko I., et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40 (2008) 768-775
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
Prokopenko, I.6
-
111
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer C.J., Speliotes E.K., Loos R.J., Li S., Lindgren C.M., Heid I.M., et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41 (2009) 25-34
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
Heid, I.M.6
-
112
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson G., Walters G.B., Gudbjartsson D.F., Steinthorsdottir V., Sulem P., Helgadottir A., et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41 (2009) 18-24
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
Steinthorsdottir, V.4
Sulem, P.5
Helgadottir, A.6
-
113
-
-
0037442122
-
Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. J
-
Pablos J.L., Santiago B., Galindo M., Torres C., Brehmer M.T., Blanco F.J., et al. Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. J. Immun 170 (2003) 2147-2152
-
(2003)
Immun
, vol.170
, pp. 2147-2152
-
-
Pablos, J.L.1
Santiago, B.2
Galindo, M.3
Torres, C.4
Brehmer, M.T.5
Blanco, F.J.6
-
114
-
-
0034945516
-
Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
-
CHD Risk Prediction Group
-
D'Agostino Jr. R.B., Grundy S., Sullivan L.M., Wilson P., and CHD Risk Prediction Group. Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation. JAMA 286 (2001) 180-187
-
(2001)
JAMA
, vol.286
, pp. 180-187
-
-
D'Agostino Jr., R.B.1
Grundy, S.2
Sullivan, L.M.3
Wilson, P.4
-
115
-
-
34547555885
-
Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study
-
Morrison A.C., Bare L.A., Chambless L.E., Ellis S.G., Malloy M., Kane J.P., et al. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 166 (2007) 28-35
-
(2007)
Am J Epidemiol
, vol.166
, pp. 28-35
-
-
Morrison, A.C.1
Bare, L.A.2
Chambless, L.E.3
Ellis, S.G.4
Malloy, M.5
Kane, J.P.6
-
116
-
-
40949149395
-
Polymorphisms associated with cholesterol and risk of cardiovascular events
-
Kathiresan S., Melander O., Anevski D., Guiducci C., Burtt N.P., Roos C., et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 358 (2008) 1240-1249
-
(2008)
N Engl J Med
, vol.358
, pp. 1240-1249
-
-
Kathiresan, S.1
Melander, O.2
Anevski, D.3
Guiducci, C.4
Burtt, N.P.5
Roos, C.6
-
117
-
-
58749087343
-
Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3
-
Paynter N.P., Chasman D.I., Buring J.E., Shiffman D., Cook N.R., and Ridker P.M. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med 150 (2009) 65-72
-
(2009)
Ann Intern Med
, vol.150
, pp. 65-72
-
-
Paynter, N.P.1
Chasman, D.I.2
Buring, J.E.3
Shiffman, D.4
Cook, N.R.5
Ridker, P.M.6
-
118
-
-
50849137811
-
PCSK9 and LDL cholesterol: unravelling the target to design the bullet
-
Costet P., Krempf M., and Cariou B. PCSK9 and LDL cholesterol: unravelling the target to design the bullet. Trends Biochem Sci 33 (2008) 426-434
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 426-434
-
-
Costet, P.1
Krempf, M.2
Cariou, B.3
-
120
-
-
0037012465
-
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
-
Higashi M.K., Veenstra D.L., Kondo L.M., Wittkowsky A.K., Srinouanprachanh S.L., Farin F.M., et al. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 287 (2002) 1690-1698
-
(2002)
JAMA
, vol.287
, pp. 1690-1698
-
-
Higashi, M.K.1
Veenstra, D.L.2
Kondo, L.M.3
Wittkowsky, A.K.4
Srinouanprachanh, S.L.5
Farin, F.M.6
-
121
-
-
0033608466
-
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
-
Aithal G.P., Day C.P., Kesteven P.J., and Daly A.K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 353 (1999) 717-719
-
(1999)
Lancet
, vol.353
, pp. 717-719
-
-
Aithal, G.P.1
Day, C.P.2
Kesteven, P.J.3
Daly, A.K.4
-
122
-
-
40449120615
-
Genetic determinants of response to warfarin during initial anticoagulation
-
Schwarz U.I., Ritchie M.D., Bradford Y., Li C., Dudek S.M., Frye-Anderson A., et al. Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med 358 (2008) 999-1008
-
(2008)
N Engl J Med
, vol.358
, pp. 999-1008
-
-
Schwarz, U.I.1
Ritchie, M.D.2
Bradford, Y.3
Li, C.4
Dudek, S.M.5
Frye-Anderson, A.6
-
123
-
-
21144448879
-
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
-
Rieder M.J., Reiner A.P., Gage B.F., Nickerson D.A., Eby C.S., McLeod H.L., et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 352 (2005) 2285-2293
-
(2005)
N Engl J Med
, vol.352
, pp. 2285-2293
-
-
Rieder, M.J.1
Reiner, A.P.2
Gage, B.F.3
Nickerson, D.A.4
Eby, C.S.5
McLeod, H.L.6
-
124
-
-
58749094444
-
Cytrochrome P-450 polymorphisms and response to clopidogrel
-
Mega J.L., Close S.L., Wiviott S.D., Shen L., Hackett R.D., Brandt J.T., et al. Cytrochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 360 (2009) 354-362
-
(2009)
N Engl J Med
, vol.360
, pp. 354-362
-
-
Mega, J.L.1
Close, S.L.2
Wiviott, S.D.3
Shen, L.4
Hackett, R.D.5
Brandt, J.T.6
-
125
-
-
58749090547
-
Genetic determinants of response to clopidogrel and cardiovascular events
-
Simon T., Verstuyft C., Mary-Krause M., Quteineh L., Drouet E., Méneveau N., et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 360 (2009) 363-375
-
(2009)
N Engl J Med
, vol.360
, pp. 363-375
-
-
Simon, T.1
Verstuyft, C.2
Mary-Krause, M.3
Quteineh, L.4
Drouet, E.5
Méneveau, N.6
-
126
-
-
1942436221
-
Mendelian randomization: prospects, potentials, and limitations
-
Smith G.D., and Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33 (2004) 30-42
-
(2004)
Int J Epidemiol
, vol.33
, pp. 30-42
-
-
Smith, G.D.1
Ebrahim, S.2
-
127
-
-
55249087635
-
Genetically elevated C-Reactive protein and ischemic vascular disease
-
Zacho J., Tybajaerg-Hansen A., Jensen J.S., Grande P., Sillesen H., and Nordestgaard B.G. Genetically elevated C-Reactive protein and ischemic vascular disease. N Engl J Med 359 (2008) 1897-1908
-
(2008)
N Engl J Med
, vol.359
, pp. 1897-1908
-
-
Zacho, J.1
Tybajaerg-Hansen, A.2
Jensen, J.S.3
Grande, P.4
Sillesen, H.5
Nordestgaard, B.G.6
-
128
-
-
55249105922
-
Elevated C-Reactive protein in atherosclerosis. Chicken or Egg?
-
Schunkert H., and Samani NJ. Elevated C-Reactive protein in atherosclerosis. Chicken or Egg?. N Engl J Med 359 (2008) 1953-1955
-
(2008)
N Engl J Med
, vol.359
, pp. 1953-1955
-
-
Schunkert, H.1
Samani, NJ.2
-
129
-
-
27944473261
-
The case for strategic international alliances to harness nutritional genomics for public and personal health
-
Kaput J., Ordovas J.M., Ferguson L., Van Ommen B., Rodriguez R.L., Allen L., et al. The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr 94 (2005) 623-632
-
(2005)
Br J Nutr
, vol.94
, pp. 623-632
-
-
Kaput, J.1
Ordovas, J.M.2
Ferguson, L.3
Van Ommen, B.4
Rodriguez, R.L.5
Allen, L.6
-
130
-
-
33751329250
-
Global variation in copy number in the human genome
-
Redon R., Ishikawa S., Fitch K.R., Feuk L., Perry G.H., Andrews T.D., et al. Global variation in copy number in the human genome. Nature 444 (2006) 444-454
-
(2006)
Nature
, vol.444
, pp. 444-454
-
-
Redon, R.1
Ishikawa, S.2
Fitch, K.R.3
Feuk, L.4
Perry, G.H.5
Andrews, T.D.6
-
131
-
-
40949156220
-
Genetic test for common diseases: new insights, old concerns
-
Melzer D., Hogarth S., Liddell K., Ling T., Sanderson S., and Zimmern R.L. Genetic test for common diseases: new insights, old concerns. BMJ 336 (2008) 590-593
-
(2008)
BMJ
, vol.336
, pp. 590-593
-
-
Melzer, D.1
Hogarth, S.2
Liddell, K.3
Ling, T.4
Sanderson, S.5
Zimmern, R.L.6
-
132
-
-
34948877698
-
Prediction of individual genetic risk to disease from genome-wide association Studies
-
Wray N.R., Goddard M.E., and Visscher P.M. Prediction of individual genetic risk to disease from genome-wide association Studies. Gen Res 17 (2007) 1520-1528
-
(2007)
Gen Res
, vol.17
, pp. 1520-1528
-
-
Wray, N.R.1
Goddard, M.E.2
Visscher, P.M.3
-
133
-
-
84888504594
-
-
1000 Genomes. Disponible en
-
1000 Genomes. Disponible en: www.1000genomes.org
-
-
-
-
134
-
-
40949112321
-
Delivery of genomic medicine for common chronic adult diseases: a systematic review
-
Scheuner M.T., Sieverding P., and Shekelle P.G. Delivery of genomic medicine for common chronic adult diseases: a systematic review. JAMA 299 (2008) 1320-1334
-
(2008)
JAMA
, vol.299
, pp. 1320-1334
-
-
Scheuner, M.T.1
Sieverding, P.2
Shekelle, P.G.3
-
135
-
-
0042855876
-
Ethical, legal, and social implications of genomic medicine
-
Clayton E.W. Ethical, legal, and social implications of genomic medicine. N Engl J Med 349 (2003) 562-569
-
(2003)
N Engl J Med
, vol.349
, pp. 562-569
-
-
Clayton, E.W.1
|