Evaluation of anesthesia recovery quality after low-dose racemic or S-ketamine infusions during anesthesia with isoflurane in horses

American Journal of Veterinary Research

Volumn 70, Issue 6, 2009, Pages 710-718

  Larenza, M Paula ^a,d   Ringer, Simone K ^a   Kutter, Annette P N ^a   Conrot, Aude ^b   Theurillat, Regula ^c   Kummer, Martin ^a   Thormann, Wolfgang ^c   Bettschart Wolfensberger, Regula ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Labor Dr E Graub AG   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOBUTAMINE; ISOFLURANE; KETAMINE; MIDAZOLAM; OXYGEN; THIOPENTAL; XYLAZINE;

ANESTHESIA; ANESTHESIA INDUCTION; ANESTHETIC RECOVERY; ARTERIAL GAS; ARTHROSCOPY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; EVALUATION; FEMALE; HEART RATE; HORSE; INFUSION; LOADING DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; SEDATION; STIMULATION;

ANALGESICS; ANESTHESIA; ANESTHESIA RECOVERY PERIOD; ANESTHETICS, INHALATION; ANIMALS; FEMALE; HORSES; ISOFLURANE; KETAMINE; MALE;

ANIMALIA; EQUIDAE;

EID: 67649482675     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.70.6.710     Document Type: Article

References (34)

1. Johnston GM, Eastment JM, Wood JL, et al. The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of phases 1 and 2. Vet Anaesth Analg 2002;29:159-170. (Pubitemid 35028003)
2. Johnston GM, Taylor PM, Holmes MA, et al. Confidential enquiry of perioperative equine fatalities (CEPEF-1): preliminary results. Equine Vet J 1995;27:193-200.
3. Bettschart-Wolfensberger R, Larenza MP. Balanced anaesthesia for horses. Clin Tech Equine Pract 2007;6:104-110.
4. Bettschart-Wolfensberger R, Taylor PM, Sear JW, et al. Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine. Am J Vet Res 1996;57:1472-1477. (Pubitemid 26356333)
5. Muir WW III, Sams R. Effects of ketamine infusion on halothane minimal alveolar concentration in horses. Am J Vet Res 1992;53:1802-1806.
6. Doenicke A, Kugler J, Mayer M, et al. Ketamine racemate or S-(+)-ketamine and midazolam. The effect on vigilance, efficacy and subjective findings [in German]. Anaesthesist 1992;41:610-618.
7. Larenza MP, Althaus H, Conrot A, et al. Anaesthesia recovery quality after racemic ketamine or S-ketamine administration to male cats undergoing neutering surgery. Schweiz Arch Tierheilkd 2008;150:599-607.
8. Filzek U, Fischer U, Ferguson J. Intravenous anaesthesia in horses: racemic ketamine versus S-(+)-ketamine. Pferdeheilkunde 2003;19:501-506. (Pubitemid 37159813)
9. Larenza MP, Knobloch M, Landoni MF, et al. Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration in Shetland ponies sedated with xylazine. Vet J 2008;177:432-435. (Pubitemid 351891503)
10. Rossetti RB, Gaido Cortopassi SR, Intelizano T, et al. Comparison of ketamine and S(+)-ketamine, with romifidine and diazepam, for total intravenous anesthesia in horses. Vet Anaesth Analg 2008;35:30-37.
11. Mama KR, Steffey EP, Pascoe PJ. Evaluation of propofol for general anesthesia in premedicated horses. Am J Vet Res 1996;57:512-516. (Pubitemid 26150182)
12. Tschudi PR. Evaluation of the portable blood analyser i-STAT [in German]. Schweiz Arch Tierheilkd 1998;140:507-512. (Pubitemid 128521604)
13. Harris EA, Kenyon AM, Nisbet HD, et al. The normal alveolar-arterial oxygen-tension gradient in man. Clin Sci Mol Med 1974;46:89-104.
14. Hardman JG, Aitkenhead AR. Estimating alveolar dead space from the arterial to end-tidal CO(2) gradient: a modeling analysis. Anesth Analg 2003;97:1846-1851. (Pubitemid 37475151)
15. Theurillat R, Knobloch M, Levionnois O, et al. Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis. Electrophoresis 2005;26:3942-3951. (Pubitemid 41576658)
16. Theurillat R, Knobloch M, Schmitz A, et al. Enantioselective analysis of ketamine and its metabolites in equine plasma and urine by CE with multiple isomer sulfated beta-CD. Electrophoresis 2007;28:2748-2757. (Pubitemid 47250280)
17. Peterbauer C, Larenza MP, Knobloch M, et al. Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies. Vet Anaesth Analg 2008;35:414-423.
18. Ryder S, Way WL, Trevor AJ. Comparative pharmacology of the optical isomers of ketamine in mice. Eur J Pharmacol 1978;49:15-23. (Pubitemid 9193621)
19. Engelhardt W, Stahl K, Marouche A, et al. Recovery time after (S)-ketamine or ketamine racemate. Recovery time after short anesthesia in volunteers [in German]. Anaesthesist 1998;47:184-192.
20. White PF, Schüttler J, Shafer A, et al. Comparative pharmacology of the ketamine isomers. Studies in volunteers. Br J Anaesth 1985;57:197-203. (Pubitemid 15093411)
21. Ihmsen H, Geisslinger G, Schüttler J. Stereoselective pharmacokinetics of ketamine: R(-)-ketamine inhibits the elimination of S(+)-ketamine. Clin Pharmacol Ther 2001;70:431-438. (Pubitemid 33135322)
22. Larenza MP, Peterbauer C, Landoni M, et al. Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies. Am J Vet Res 2009;70:in press.
23. Kharasch ED, Labroo R. Metabolism of ketamine stereoisomers by human liver microsomes. Anesthesiology 1992;77:1201-1207. (Pubitemid 23001132)
24. Schmitz A, Portier CJ, Thormann W, et al. Stereoselective biotransformation of ketamine in equine liver and lung microsomes. J Vet Pharmacol Ther 2008;31:446-455.
25. Larenza MP, Landoni MF, Levionnois OL, et al. Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies. Br J Anaesth 2007;98:204-212. (Pubitemid 47078642)
26. Knobloch M, Portier CJ, Levionnois OL, et al. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion. Toxicol Appl Pharmacol 2006;216:373-386. (Pubitemid 44596230)
27. Sear JW. Continuous infusion of hypnotic agents for maintenance of anaesthesia. In: Kay B, ed. Total intravenous anaesthesia. Amsterdam: Elsevier Science, 1991;38-40.
28. Arendt-Nielsen L, Nielsen J, Petersen-Felix S, et al. Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain. Br J Anaesth 1996;77:625-631. (Pubitemid 26385793)
29. Schatzmann U. Pulmonary perfusion and ventilation: a mismatch? Equine Vet J 1995;27:80-81.
30. Moens Y, Lagerweij E, Gootjes P, et al. Distribution of inspired gas to each lung in the anaesthetised horse and influence of body shape. Equine Vet J 1995;27:110-116.
31. 2 in hypoxaemic anaesthetized horses - a prospective clinical trial in 81 horses. Vet Anaesth Analg 2002;29:212-218. (Pubitemid 35028008)
32. Taylor PM. Effects of hypoxia on endocrine and metabolic responses to anaesthesia in ponies. Res Vet Sci 1999;66:39-44. (Pubitemid 29082289)
33. Moens Y. Arterial-alveolar carbon dioxide tension difference and alveolar dead space in halothane anaesthetised horses. Equine Vet J 1989;21:282-284.
34. Picek S, Kalchofer K, Fürst T, et al. Comparison of cardiovascular function under controlled (CV) and spontaneous (SV) ventilation in horses anesthetized using isoflurane/medetomidine, in Proceedings. Spring Meet Assoc Vet Anaesth 2006;56.