Acute amiodarone toxicity due to an administration error: Could excipient be responsible?: Letter to the Editors

British Journal of Clinical Pharmacology

Volumn 67, Issue 6, 2009, Pages 691-693

  Masi, Silvana ^a   De Cléty, Stéphan Clément ^a   Anslot, Christine ^a   Detaille, Thierry ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMIODARONE; DOBUTAMINE; MILRINONE;

CARDIOGENIC SHOCK; CASE REPORT; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG OVERDOSE; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEMODYNAMICS; HUMAN; HYPOTENSION; LACTIC ACIDOSIS; LETTER; MEDICAL ERROR; MULTIPLE ORGAN FAILURE; NEWBORN; PERFUSION; PRIORITY JOURNAL; RESUSCITATION; SUPRAVENTRICULAR TACHYCARDIA;

AMIODARONE; ANTI-ARRHYTHMIA AGENTS; BENZYL ALCOHOL; EXCIPIENTS; HUMANS; INFANT, NEWBORN; INFUSIONS, INTRAVENOUS; POLYSORBATES; TACHYCARDIA, SUPRAVENTRICULAR;

EID: 67649476429     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2008.03323.x     Document Type: Letter

References (12)

1. Gill J, Heel R, Fitton A. Amiodarone. An overview of its pharmacological properties and review of its therapeutic use in cardiac arrythmias. Drugs 1992 43 : 69 110.
2. Munoz A, Karila P, Gallay P, Zetteleier F, Messner P, Mery M, Grolleau R. A randomised haemodynamic comparison of intravenous amiodarone with and without Tween 80®. Eur Heart J 1988 9 : 142 8.
3. Gough WB, Zeiler RH, Barreca P, El Sherif N. Hypotensive action of commercial intravenous amiodarone and polysorbate 80 in dogs. J Cardiovasc Pharmacol 1982 4 : 375 80.
4. Yasaka WJ, Eichbaum F, Oga S. Antiarrythmic effects of solvents: effects of propylene glycol and benzyl alcohol on contractile force of isolated rabbit heart. Cardiovasc Res 1979 13 : 717 22.
5. Kimura ET, Darby TD, Krause RA, HD B. Parenteral toxicity studies with benzyl alcohol. Toxicol Appl Pharmacol 1971 18 : 60.
6. Center for Disease Control and Prevention. Neonatal deaths associated with use of benzyl alcohol - United States. MMWR Morb Mortal Wkly Rep 1982 31 : 290 1.
7. Brown WJ, Buist NRM, Gipson HTC, Huston RK, Kennaway NG. Fatal benzyl alcohol poisoning in a neonatal intensive care unit. Lancet 1982 1 : 1250.
8. Gallik DM, Singer I, Meissner M, Molnar J, Somberg J. Haemodynamic and surface electrocardiographic effects of a new aqueous formulation of intravenous amiodarone. Am J Cardiol 2002 90 : 964 8.
9. Somberg JC, Cventanovic I, Ranade V, Molnar J. Comparative effects of rapid administration of aqueous amiodarone vs 10-min cordarone IV infusion on mean arterial blood pressure in conscious dogs. Cardiovasc Drugs Ther 2004 18 : 345 51.
10. Salgado H, Simoes G, Santana Filho V, Dias Da Silva V, Salgado MC. Negative inotropic and lusotropic effects of intravenous amiodarone in conscious rats. Clin Exp Pharmacol Physiol 2007 34 : 870 5.
11. Somberg JC, Timar S, Bailin SJ, Lakatos F, Haffajee CI, Tarjan J, Paladino WP, Sarosi I, Kerin NZ, Borbola J, Bridges DE, Molnar J. Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone. Am J Cardiol 2004 93 : 576 81.
12. Burri S, Hug MI, Bauersfeld U. Efficacy and safety of IV amiodarone for incessant tachycardias in infants. Eur J Pediatr 2003 162 : 880 4.