Partner preference and mount latency are masculinized in androgen insensitive rats

Physiology and Behavior

Volumn 98, Issue 1-2, 2009, Pages 25-30

  Hamson, Dwayne K ^a   Csupity, Attila S ^a   Ali, Faezah M ^a   Watson, Neil V ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Androgen insensitivity; Androgen receptor; Partner preference; Sexual behavior; Testicular feminization mutation

Indexed keywords

ANDROGEN RECEPTOR;

ANDROGEN INSENSITIVITY SYNDROME; ANESTRUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COITUS; CONTROLLED STUDY; ESTRUS; FEMALE; GENE MUTATION; MALE; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEXUAL AROUSAL; SEXUAL BEHAVIOR; VIRILIZATION; WILD TYPE;

ANDROGEN-INSENSITIVITY SYNDROME; ANIMALS; AROUSAL; COPULATION; ESTROUS CYCLE; FEMALE; MALE; MOTIVATION; OVARIECTOMY; PREGNANCY; RATS; RECEPTORS, ANDROGEN; SEXUAL BEHAVIOR, ANIMAL;

EID: 67649467335     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2009.04.008     Document Type: Article

References (34)

1. Everitt B.J. Sexual motivation: a neural and behavioral analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci Biobehav Rev 14 (1990) 217-232
2. Harding S.M., and McGinnis M.Y. Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors. Physiol Behav 81 (2004) 671-680
3. Bakker J., Van Ophemert J., and Slob A.K. Sexual differentiation of odor and partner preference in the rat. Physiol Behav 60 (1994) 489-494
4. Pfaus J.G. Revisiting the concept of sexual motivation. Annu Rev Sex Res 10 (1999) 120-156
5. Sachs B.D., Pollak E.K., Krieger M.S., and Barfield R.J. Sexual behavior: normal male patterning in androgenized female rats. Science 181 (1973) 770-772
6. Allison J.E., Chan F., Stanley A.J., and Gumbreck L.G. Androgen insensitivity in male pseudohermaphrodite rats. Endocrinology 89 (1971) 615-617
7. Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., et al. A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J. Biol. Chem. 265 (1990) 8893-8900
8. Roselli C.E., Salisbury R.L., and Resko J.A. Genetic evidence for androgen-dependent and independent control of aromatase activity in the rat brain. Endocrinology 121 (1987) 2205-2210
9. Ohno S., Geller L.N., and Young Lai E.V. Tfm mutation and masculinization versus feminization of the mouse central nervous system. Cell 3 (1974) 235-242
10. Shapiro B.H., Goldman A.S., Steinbeck H.F., and Neumann F. Is feminine differentiation of the brain hormonally determined?. Experientia 32 (1976) 650-651
11. Beach F.A., and Buehler M.G. Male rats with inherited insensitivity to androgen show reduced sexual behavior. Endocrinology 100 (1977) 197-200
12. Olsen K.L. Induction of male mating behavior in androgen-insensitive (tfm) and Normal (King-Holtzman) male rats: effect of testosterone propionate, estradiol benzoate, and dihydrotestosterone. Horm Behav 13 (1979) 66-84
13. Olsen K.L., and Whalen R.E. Hormonal control of the development of sexual behavior in androgen-insensitive (tfm) rats. Physiol Behav 27 (1981) 883-886
14. Fox T.O. Androgen- and estrogen-binding macromolecules in developing mouse brain: biochemical and genetic evidence. Proc Natl Acad Sci U S A 72 (1975) 4303-4307
15. Bodo C., and Rissman E.F. Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice. Eur J Neurosci 25 (2007) 2182-2190
16. Fernandez R., Collado P., Garcia-Doval S., Garcia-Falgueras A., Guillamon A., and Pasaro E. A molecular method for classifying the genotypes obtained in a breeding colony from testicular feminized (Tfm) rats. Horm Metab Res 35 (2003) 197-200
17. Edwards D.A., and Pfeifle J.K. Hormonal control of receptivity, proceptivity and sexual motivation. Physiol Behav 30 (1983) 437-443
18. Young C.Y., Johnson M.P., Prescott J.L., and Tindall D.J. The androgen receptor of the testicular-feminized (Tfm) mutant mouse is smaller than the wild-type receptor. Endocrinology 124 (1989) 771-775
19. He W.W., Kumar M.V., and Tindall D.J. A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 19 (1991) 2373-2378
20. Breedlove S.M., and Arnold A.P. Sexually dimorphic motor nucleus in the rat lumbar spinal cord: response to adult hormone manipulation, absence in androgen-insensitive rats. Brain Res 225 (1981) 297-307
21. Watson N.V., Freeman L.M., and Breedlove S.M. Neuronal size in the spinal nucleus of the bulbocavernosus: direct modulation by androgen in rats with mosaic androgen insensitivity. J Neurosci 21 (2001) 1062-1066
22. Morris J.A., Jordan C.L., Dugger B.N., and Breedlove S.M. Partial demasculinization of several brain regions in adult male (XY) rats with a dysfunctional androgen receptor gene. J Comp Neurol 487 (2005) 217-226
23. Jones B.A., and Watson N.V. Spatial memory performance in androgen insensitive male rats. Physiol Behav 85 (2005) 135-141
24. Field E.F., Whishaw I.Q., Pellis S.M., and Watson N.V. Play fighting in androgen-insensitive tfm rats: evidence that androgen receptors are necessary for the development of adult playful attack and defense. Dev Psychobiol 48 (2006) 111-120
25. Naess O., Haug E., Attramadal A., Aakvaag A., Hansson V., and French F. Androgen receptors in the anterior pituitary and central nervous system of the androgen "insensitive" (Tfm) rat: correlation between receptor binding and effects of androgens on gonadotropin secretion. Endocrinology 99 (1976) 1295-1303
26. Olsen K.L., and Whalen R.E. Estrogen binds to hypothalamic nuclei of androgen-insensitive (tfm) rats. Experientia 38 (1982) 139-140
27. Bakker J., Honda S., Harada N., and Balthazart J. Sexual partner preference requires a functional aromatase (cyp19) gene in male mice. Horm Behav 42 (2002) 158-171
28. Wersinger S.R., and Rissman E.F. Oestrogen receptor alpha is essential for female-directed chemo-investigatory behavior but is not required for the pheromone-induced luteinizing hormone surge in male mice. J Neuroendocrinol 12 (2002) 103-110
29. Brand T., Kroonen J., Mos J., and Slob A.K. Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations. Horm Behav 25 (1991) 323-341
30. Bakker J., Brand T., van Ophemert J., and Slob A.K. Hormonal regulation of adult partner preference behavior in neonatally ATD-treated male rats. Behav Neurosci 107 (1993) 480-487
31. Bakker J., van Ophemert J., Timmerman M.A., de Jong F.H., and Slob A.K. Endogenous reproductive hormones and nocturnal rhythms in partner preference and sexual behavior of ATD-treated male rats. Neuroendocrinology 62 (1995) 396-405
32. Kaplan M.E., and McGinnis M.Y. Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis. Horm Behav 23 (1989) 0-26
33. Vagell M.E., and McGinnis M.Y. The role of aromatization in the restoration of male rat reproductive behavior. J Neuroendocrinol 9 (1997) 415-421
34. Sato T., Matsumoto T., Kawano H., Watanabe T., Uematsu Y., Sekine K., et al. Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A 101 (2004) 1673-1678