Comparative 1H NMR-based metabonomic analysis of HIV-1 sera

Journal of Biomolecular NMR

Volumn 44, Issue 3, 2009, Pages 127-137

  Philippeos, C ^a   Steffens, F E ^b   Meyer, Debra ^b  

^a UNIVERSITY OF JOHANNESBURG   (South Africa)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

HIV AIDS; Metabonomics; Multinomial logistic regression; Multivariate statistics

Indexed keywords

ANTIRETROVIRUS AGENT;

ACCURACY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INTERMETHOD COMPARISON; METABOLOMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SENSITIVITY ANALYSIS; BLOOD; COMPARATIVE STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; STATISTICAL MODEL;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-RETROVIRAL AGENTS; HIV INFECTIONS; HIV-1; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE SPECTROSCOPY;

EID: 67649408723     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-009-9329-8     Document Type: Article

References (15)

1. 1H NMR spectroscopy of human blood plasma. Prog NMR Spectrosc 27:475-554
2. 1H NMR spectroscopic data to investigate a relationship between human serum emtabolic profiles and hypertension. Nat Med 8:1439-1444
3. Calza L, Manfredi R, Chiodi F (2003) Hyperlipidaemia in patients with HIV-1 infection receiving highly active antiretroviral therapy: epidemiology, pathogenesis, clinical course and management Int. J Antimicrob Agents 22:89-99
4. Fukunaga K (1990) Introduction to statistical pattern recognition. Academic Press, San Diego
5. 1H NMR-based metabonomic techniques to distinguish between HIV-1 positive/AIDS patients on antiretroviral treatment and HIV-1 negative individuals. J Pharm Biomed Anal 41(4):1442-1446
6. 1H NMR-based metabonomic urinalysis. Chem Res Toxicol 15:1380-1386
7. Lindon JC (2004) In: CooperFE (ed) Business briefing: future drug discovery. World Markets Research Center Ltd, London, pp 1-6
8. 1H diffusion-edited total-correlation NMR spectroscopy. Anal Chem 69:1504-1509
9. Meyerhoff DJ, Bloomer C, Cardenas V, Norman D, Weiner MW, Fein G (1999) Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients. Neurology 52:995-1003
10. Navia BA, Cho ES, Petito CK, Price RW (1986) The AIDS dementia complex: II. Neuropathology. Ann Neurol 19:525-535
11. Nicholson JK, Wilson ID (1989) High resolution proton magnetic resonance spectroscopy of biological fluids. Prog NMR Spectrosc 21:449-501
12. 13C NMR spectroscopy of human blood plasma. Anal Chem 67:793-811
13. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data. Xenobiotica 29:1181-1189
14. Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: A platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1:153-161
15. Ramadan Z, Jacobs D, Grigorov M, Kochhar S (2006) Metabolic profiling using principal component analysis, discriminant partial least squares and genetic algorithms. Talanta 68:1683-1691