The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes

Brain

Volumn 132, Issue 6, 2009, Pages 1496-1508

  Koodziejczyk, Karolina ^a   Hamilton, Nicola B ^a   Wade, Anna ^a   Kradttir, Ragnhildur ^b   Attwell, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Canavans disease; Glutamate; Leucodystrophy; NMDA; Pelizaeus Merzbacher like disease

Indexed keywords

CALCIUM ION; METABOTROPIC RECEPTOR; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TETRODOTOXIN; ASPARTIC ACID; CALCIUM; DIPEPTIDE; DRUG DERIVATIVE; GLUTAMIC ACID; N ACETYL 1 ASPARTYLGLUTAMIC ACID; N-ACETYL-1-ASPARTYLGLUTAMIC ACID; N-ACETYLASPARTATE;

ARTICLE; CELL DEATH; CONTROLLED STUDY; EVOKED CORTICAL RESPONSE; GRANULE CELL; GRAY MATTER; LEUKODYSTROPHY; MEMBRANE CURRENT; NERVE POTENTIAL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; WHITE MATTER; ACTION POTENTIAL; ANIMAL; CANAVAN DISEASE; CEREBELLUM; DRUG ANTAGONISM; DRUG EFFECT; EVOKED RESPONSE; HYDROLYSIS; METABOLISM; PATCH CLAMP; PATHOLOGY; PELIZAEUS MERZBACHER DISEASE; PHYSIOLOGY; TISSUE CULTURE TECHNIQUE;

ACTION POTENTIALS; ANIMALS; ASPARTIC ACID; CALCIUM; CANAVAN DISEASE; CEREBELLUM; DIPEPTIDES; EVOKED POTENTIALS; GLUTAMIC ACID; HYDROLYSIS; OLIGODENDROGLIA; PATCH-CLAMP TECHNIQUES; PELIZAEUS-MERZBACHER DISEASE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE CULTURE TECHNIQUES;

EID: 67649391201     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awp087     Document Type: Article

References (37)

1. Bakiri Y, Hamilton NB, Káradóttir R, Attwell D. Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Glia 2008; 56: 233-40.
2. Baslow MH. N-acetylaspartate and N-acetylaspartylglutamate. In: Oja SS, Schousboe A, Saransaari P, editors. Chapter 14 of Handbook of neurochemistry and molecular neurobiology: amino acids and peptides in the nervous system. 3rd edn., Springer, Berlin; 2007.
3. Berger UV, Luthi-Carter R, Passani LA, Elkabes S, Black I, Konradi C, et al. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. J Comp Neurol 1999; 415: 52-64.
4. Bergeron R, Coyle JT, Tsai G, Greene RW. NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons. Neuropsychopharmacology 2005; 30: 7-16.
5. Billups D, Attwell D. Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse. Eur J Neurosci 2003; 18: 2975-80.
6. Burlina AP, Ferrari V, Divry P, Gradowska W, Jakobs C, Bennett MJ, et al. N-acetylaspartylglutamate in Canavan disease: an adverse effector? Eur J Pediatr 1999; 158: 406-9.
7. Burlina AP, Skaper SD, Mazza MR, Ferrari V, Leon A. Burlina AB. N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro. J Neurochem 1994; 63: 1174-7.
8. Bzdega T, Crowe SL, Ramadan ER, Sciarretta KH, Olszewski RT, Ojeifo OA, et al. The cloning and characterization of a second brain enzyme with NAAG peptidase activity. J Neurochem 2004; 89: 627-35.
9. Chakraborty G, Mekala P, Yahya D, Wu G, Ledeen RW. Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J Neurochem 2001; 78: 736-45.
10. Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, et al. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 2002; 415: 793-8.
11. D'Angelo E, Rossi P, Teglietti V. Different proportions of N-methyl-Daspartate and non-N-methyl-D-aspartate receptor currents at the mossy fibre-granule cell synapse of developing rat cerebellum. Neuroscience 1993; 53: 121-30.
12. Fenwick EM, Marty A, Neher E. A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine. J Physiol 1982; 331: 577-97.
13. Fields RD. White matter in learning, cognition and psychiatric disorders. Trends Neurosci 2008; 31: 361-70.
14. Follett PL, Rosenberg PA, Volpe JJ, Jensen FE. NBQX attenuates excitotoxic injury in developing white matter. J Neurosci 2000; 20: 9235-41.
15. Jackson PF, Cole DC, Slusher BS, Stetz SL, Ross LE, Donzanti BA, et al. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase, J Med Chem 1996; 39: 619-22.
16. Jakobs C, ten Brink HJ, Langelaar SA, Zee T, Stellaard F, Macek M, et al. Stable isotope dilution analysis of N-acetylaspartic acid in CSF, blood, urine and amniotic fluid: accurate postnatal diagnosis and the potential for prenatal diagnosis of Canavan disease. J Inherit Metab Dis 1991; 14: 653-60.
17. Jane DE, Thomas NK, Tse HW, Watkins JC. Potent antagonists at the L-AP4- and (1S, 3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology 1996; 35: 1029-35.
18. Káradóttir R, Attwell D. Combining patch-clamping of cells in brain slices with immunocytochemical labeling to define cell type and developmental stage. Nat Protoc 2006; 1: 1977-86.
19. Káradóttir R, Cavelier P, Bergersen LH, Attwell D. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature 2005; 438: 1162-6.
20. Káradóttir R, Hamilton NB, Bakiri Y, Attwell D. Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter. Nat Neurosci 2008; 11: 450-6.
21. Khwaja O, Volpe JJ. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed 2008; 93: F153-61.
22. 2+ in vitro. Neuroreport 1994; 5: 1063-8.
23. Kumar S, Mattan NS, de Vellis J. Canavan disease: a white matter disorder. Ment Retard Dev Disabil Res Rev 2006; 12: 157-65.
24. a+-dependent glutamate transport. J Neurosci 1999; 19: RC16.
25. Micu I, Jiang Q, Coderre E, Ridsdale A, Zhang L, Woulfe J, et al. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 2006; 439: 988-92.
26. Pliss L, FitzGibbon T, Balcar VJ, St'astný F. Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands. Neuroreport 2000; 11: 3651-4.
27. Rubin Y, LaPlaca MC, Smith DH, Thibault LE, Lenkinski RE. The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons. Neurosci Lett 1995; 198: 209-12.
28. Salter MG, Fern R. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury. Nature 2005; 438: 1167-71.
29. Sartori S, Burlina AB, Salviati L, Trevisson E, Toldo I, Laverda AM, et al. Increased level of N-acetylaspartylglutamate (NAAG) in the CSF of a patient with Pelizaeus-Merzbacher-like disease due to mutation in the GJA12 gene. Eur J Paediatr Neurol 2008; 12: 348-50.
30. Sekiguchi M, Wada K, Wenthold RJ. N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes. FEBS Lett 1992; 311: 285-9.
31. Tortella FC, Lin Y, Ved H, Slusher BS, Dave JR. Neuroprotection produced by the NAALADase inhibitor 2-PMPA in rat cerebellar neurons. Eur J Pharmacol 2000; 402: 31-7.
32. Valivullah HM, Lancaster J, Sweetnam PM, Neale JH. Interactions between N-acetylaspartylglutamate and AMPA, kainate, and NMDA binding sites. J Neurochem 1994; 63: 1714-9.
33. Westbrook GL, Mayer ML, Namboodiri MA, Neale JH. High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture. J Neurosci 1986; 6: 3385-92.
34. Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreëls FJ, Heerschap A. Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem 1995; 41: 744-51.
35. Wolf NI, Willemsen MA, Engelke UF, van der Knaap MS, Pouwels PJ, Harting I, et al. Severe hypomyelination associated with increased levels of N-acetylaspartylglutamate in CSF. Neurology 2004; 62: 1503-8.
36. Wroblewska B, Santi MR, Neale JH. N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 1998; 24: 172-9.
37. Wroblewska B, Wroblewski JT, Pshenichkin S, Surin A, Sullivan SE, Neale JH. N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J Neurochem 1997; 69: 174-81.