The effects of PC-Spes on chemosensitive and chemoresistant head and neck cancer cells and primary mucosal keratinocytes

Oncology Reports

Volumn 21, Issue 5, 2009, Pages 1297-1305

  Schmidt, Marianne ^a   Polednik, Christine ^a   Gruensfelder, Petra ^a   Roller, Jeanette ^a   Hagen, Rudolf ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Apoptosis; Head and neck carcinoma; Herbal drug; Paclitaxel; PC Spes

Indexed keywords

PACLITAXEL; PC SPES; TUBULIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CELL CYCLE G2 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL SURVIVAL; CONTROLLED STUDY; DRUG SENSITIVITY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUGS, CHINESE HERBAL; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KERATINOCYTES; LARYNGEAL NEOPLASMS; NEOPLASMS, SQUAMOUS CELL; PACLITAXEL; TUBULIN;

EID: 67649385981     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000354     Document Type: Article

References (23)

1. DiPaola RS, Zang H, Lambert GH, Meeker R, Licitra E, Rafi MM, Zhu BT, Spaulding H, Goodin S, Toledano MB, Hait WN and Gallo MA: Clinical and biologic activity of an estrogenic herbal combination (PC-Spes) in prostate cancer. N Engl J Med 339: 785-791, 1998.
2. De la Taille A, Buttyan R, Hayek O, Bagiella E, Shabsigh A, Burchardt M, Burchardt T, Chopin DK and Katz AE: Herbal therapy PC-Spes: in vitro effects and evaluation of its efficacy in 69 patients with prostate cancer. J Urol 164: 1229-1234, 2000.
3. Moyad MA, Pienta KJ and Montie JE: Use of PC-Spes, a commercially available supplement for prostate cancer, in a patient with hormone-naive disease. Urology 54: 319-324, 1999.
4. Small EJ, Frohlich MW, Bok R, Shinohara K, Grossfeld G, Rozenblat Z, Kelly WK, Corry M and Reese DM: Prospective trial of the herbal supplement PC-Spes in patients with progressive prostate cancer. J Clin Oncol 18: 3595-3603, 2000.
5. Pfreundner L, Hoppe F, Willner J, Preisler V, Bratengeier K, Hagen R, Helms J and Flentje M: Induction chemotherapy with paclitaxel and cisplatin and CT-based 3D radiotherapy in patients with advanced laryngeal and hypopharyngeal carcinomas - a possibility for organ preservation. Radiother Oncol 68: 163-170, 2003.
6. Schmidt M, Schler G, Gruensfelder P and Hoppe F: Differential gene expression in a paclitaxel-resistant clone of a head and neck cancer cell line. Eur Arch Otorhinolaryngol 263: 127-134, 2006.
7. Zenner HP, Lehner W and Herrmann IF: Establishment of carcinoma cell lines from larynx and submandibular gland. Arch Otorhinolaryngol 225: 269-277, 1979.
8. McFarland D: Preparation of pure cell cultures by cloning. Methods Cell Sci 22: 63-66, 2000.
9. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
10. Kyhse-Andersen J: Electroblotting of multiple gels: a simple apparatus without tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Biochem Biophys Methods 10: 203-210, 1984.
11. Huerta S, Arteaga JN, Irwin RW, Ikezoe T, Heber D and Koeffler HP: PC-Spes inhibits colon cancer growth in vitro and in vivo. Cancer Res 62: 5204-5209, 2002.
12. Schwarz RE, Donohue CA, Sadava D and Kane SE: Pancreatic cancer in vitro toxicity mediated by chinese herbs Spes and PC-Spes: implications for monotherapy and combination treatment. Cancer Lett 189: 59-68, 2003.
13. Bonham MJ, Galkin A, Montgomery B, Stahl WL, Agus D and Nelson PS: Effects of the herbal extract PC-Spes on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition. J Natl Cancer Inst 94: 1641-1647, 2002.
14. Kubota T, Hisatake J, Hisatake Y, Said JW, Chen SS, Holden S, Taguchi H and Koeffler HP: PC-Spes: a unique inhibitor of proliferation of prostate cancer cells in vitro and in vivo. The Prostate 42: 163-171, 2000.
15. Ikezoe T, Chen SS, Heber D, Taguchi H and Koeffler HP: Baicalin is a major component of PC-Spes which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. Prostate 49: 285-292, 2001.
16. Franek KJ, Zhou Z, Zhang WD and Chen WY: In vitro studies of baicalin alone or in combination with Salvia miltiorrhiza extract as a potential anti-cancer agent. Int J Oncol 26: 217-224, 2005.
17. Sartippour MR, Seeram NP, Heber D, Hardy M, Norris A, Lu Q, Zhang L, Lu M, Rao JY and Brooks MN: Rabdosia rubescens inhibits breast cancer growth and angiogenesis. Int J Oncol 26: 121-127, 2005.
18. Meade-Tollin LC, Wijeratne EM, Cooper D, Guild M, Jon E, Fristz A, Zhou GX, Whitesell L, Liang JY and Gunatilaka AAL: Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC Spes. J Nat Prod 67: 2-4, 2004.
19. Lian Z, Fujimoto J, Yokoyama Y, Niwa K and Tamaya T: Herbal complex suppresses telomerase activity in chemoendocrine resistant cancer cell line. Eur J Gynaecol Oncol 22: 347-349, 2001.
20. Bonham MJ, Arnold H, Montgomery B and Nelson PS: Molecular effects of the herbal compound PC-Spes: Identification of activity pathways in prostate carcinoma. Cancer Res 62: 3920-3924, 2002.
21. Pandha HS and Kirby RS: PC-Spes: Phytotherapy for prostate cancer. Lancet 359: 2213-2214, 2002.
22. Moyer P: Reformulated PC-SPES may become available. Oncol Times 25: 32-35, 2003.
23. Shabbir M, Love J and Montgomery B: Phase I trial of PC-Spes2 in advanced homone refractory prostate cancer. Oncol Rep 19: 831-835, 2008.