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Tran, Z.V.6
Kahl, A.7
Neumann, U.8
Neuhaus, P.9
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Pageaux GP, Rostaing L, Calmus Y, et al. Mycophenolate mofetil in combination with reduction of calcineurin inhibitors for chronic renal dysfunction after liver transplantation. Liver Transpl 2006; 12:1755-1760. (Pubitemid 44920019)
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Pageaux, G.-P.1
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Hardgwissen, J.6
Bernard, P.-H.7
Barbotte, E.8
Vercambre, L.9
Bismuth, M.10
Puche, P.11
Navarro, F.12
Larrey, D.13
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39
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Mycophenolate mofetil monotherapy in patients who underwent liver transplantation for hepatitis C cirrhosis
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In this article, the authors analyze the influence of MMF monotherapy on the clinical course of recurrent hepatitis C. No significant changes in liver function tests were seen after conversion from CNI to MMF monotherapy. However, transient improvement in renal function and BP were observed
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Manrique A, Jimenez C, Ortega P, et al. Mycophenolate mofetil monotherapy in patients who underwent liver transplantation for hepatitis C cirrhosis. Transplant Proc 2008; 40:2962-2964. In this article, the authors analyze the influence of MMF monotherapy on the clinical course of recurrent hepatitis C. No significant changes in liver function tests were seen after conversion from CNI to MMF monotherapy. However, transient improvement in renal function and BP were observed.
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Transplant Proc
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Manrique, A.1
Jimenez, C.2
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Sirolimus monotherapy in nephrotoxicity due to calcineurin inhibitors in liver transplant recipients
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Nair S, Eason J, Loss G. Sirolimus monotherapy in nephrotoxicity due to calcineurin inhibitors in liver transplant recipients. Liver Transpl 2003; 9:126-129. (Pubitemid 36204562)
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Nair, S.1
Eason, J.2
Loss, G.3
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41
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Sirolimus conversion after liver transplantation: Improvement in measured glomerular filtration rate after 2 years
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DOI 10.1016/j.transproceed.2005.10.019, PII S0041134505011693
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Sanchez EQ, Martin AP, Ikegami T, et al. Sirolimus conversion after liver transplantation: improvement in measured glomerular filtration rate after 2 years. Transplant Proc 2005; 37:4416-4423. (Pubitemid 43016046)
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Sanchez, E.Q.1
Martin, A.P.2
Ikegami, T.3
Uemura, T.4
Narasimhan, G.5
Goldstein, R.M.6
Levy, M.F.7
Chinnakotla, S.8
Dawson III, S.9
Randall, H.B.10
Saracino, G.11
Klintmaim, G.B.12
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42
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37549021099
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A randomized controlled trial of late conversion from calcineurin inhibitor (CNI)-based to sirolimus-based immunosuppression in liver transplant recipients with impaired renal function
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This is one of the first randomized controlled trials to assess the safety and efficacy of CNI-to-sirolimus conversion for renal sparing in liver transplant recipients. In addition, GFR is measured by 51Cr-EDTA clearance, which is the gold standard for GFR estimation
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Watson CJE, Gimson AES, Alexander GJ, et al. A randomized controlled trial of late conversion from calcineurin inhibitor (CNI)-based to sirolimus-based immunosuppression in liver transplant recipients with impaired renal function. Liver Transpl 2007; 13:1694-1702. This is one of the first randomized controlled trials to assess the safety and efficacy of CNI-to-sirolimus conversion for renal sparing in liver transplant recipients. In addition, GFR is measured by 51Cr-EDTA clearance, which is the gold standard for GFR estimation.
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Liver Transpl
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Watson, C.J.E.1
Gimson, A.E.S.2
Alexander, G.J.3
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Sirolimus monotherapy effectiveness in liver transplant recipients with renal dysfunction owing to calcineurin inhibitors
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Di Benedetto F, Di Sandro S, De Ruvo N, et al. Sirolimus monotherapy effectiveness in liver transplant recipients with renal dysfunction owing to calcineurin inhibitors. J Clin Gastroenterol 2008 Dec 3. [Epub ahead of print]
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J Clin Gastroenterol
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Di Benedetto, F.1
Di Sandro, S.2
De Ruvo, N.3
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44
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45449115549
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Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency
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This article demonstrates that tacrolimus-to-sirolimus conversion therapy is well tolerated and effective in stable OLT recipients with tacrolimus-related chronic renal insufficiency at a median follow-up of 2.4 years. Conversion was performed at a median of 8.5 months after OLT. The authors suggest that conversion is well tolerated when timed appropriately, and chronic nephrotoxicity may be ameliorated by early conversion
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Yang YJ, Chen LX, Li LX, et al. Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. Transplant Proc 2008; 40:1541-1544. This article demonstrates that tacrolimus-to-sirolimus conversion therapy is well tolerated and effective in stable OLT recipients with tacrolimus-related chronic renal insufficiency at a median follow-up of 2.4 years. Conversion was performed at a median of 8.5 months after OLT. The authors suggest that conversion is well tolerated when timed appropriately, and chronic nephrotoxicity may be ameliorated by early conversion.
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(2008)
Transplant Proc
, vol.40
, pp. 1541-1544
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Yang, Y.J.1
Chen, L.X.2
Li, L.X.3
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45
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53649096384
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A retrospective study of conversion from tacrolimus-based to sirolimus-based immunosuppression in orthotopic liver transplant recipients
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The authors demonstrate that sirolimus conversion therapy resulted in significant improvement in renal function. However, in the early postoperative period, sirolimus combination therapy with either a CNI or MMF is recommended to prevent acute rejection
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Yu S, He X, Yang L, et al. A retrospective study of conversion from tacrolimus-based to sirolimus-based immunosuppression in orthotopic liver transplant recipients. Exp Clin Transplant 2008; 6:113-117. The authors demonstrate that sirolimus conversion therapy resulted in significant improvement in renal function. However, in the early postoperative period, sirolimus combination therapy with either a CNI or MMF is recommended to prevent acute rejection.
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(2008)
Exp Clin Transplant
, vol.6
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Yu, S.1
He, X.2
Yang, L.3
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Sirolimus conversion in liver transplant recipients with renal dysfunction: A combination with reduction of calcineurin inhibitors for chronic renal dysfunction after liver transplantation
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Shenoy S, Hardinger KL, Crippin J, et al. Sirolimus conversion in liver transplant recipients with renal dysfunction: a combination with reduction of calcineurin inhibitors for chronic renal dysfunction after liver transplantation. Liver Transpl 2007; 83:1389-1392.
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Shenoy, S.1
Hardinger, K.L.2
Crippin, J.3
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47
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Sirolimus in liver transplant recipients with renal dysfunction offers no advantage over low-dose calcineurin inhibitor regimens
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These authors were among the first to compare sirolimus conversion for renal preservation using a well matched CNI reduction control arm. The authors demonstrate that conversion to sirolimus in liver transplant patients with chronic renal insufficiency is associated with stabilization of renal function but confers no additional benefit to low-dose CNIs. In contrast, conversion therapy may be disadvantageous in patients with a CrCl of less than 30 ml/min. Large-scale, multicenter, randomized controlled trials are still needed
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Dubay D, Smith RJ, Qiu KG, et al. Sirolimus in liver transplant recipients with renal dysfunction offers no advantage over low-dose calcineurin inhibitor regimens. Liver Transpl 2008; 14:651-659. These authors were among the first to compare sirolimus conversion for renal preservation using a well matched CNI reduction control arm. The authors demonstrate that conversion to sirolimus in liver transplant patients with chronic renal insufficiency is associated with stabilization of renal function but confers no additional benefit to low-dose CNIs. In contrast, conversion therapy may be disadvantageous in patients with a CrCl of less than 30 ml/min. Large-scale, multicenter, randomized controlled trials are still needed.
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(2008)
Liver Transpl
, vol.14
, pp. 651-659
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Dubay, D.1
Smith, R.J.2
Qiu, K.G.3
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Posttransplantation chronic renal damage in nonrenal transplant recipients
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DOI 10.1111/j.1523-1755.2005.00558.x, PII 4494748
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Stratta P, Canavese C, Quaglia M, et al. Posttransplantation chronic renal damage in nonrenal transplant recipients. Kidney Int 2005; 68:143-146. (Pubitemid 43169892)
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Stratta, P.1
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Balzola, F.4
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Busca, A.6
Franchello, A.7
Libertucci, D.8
Mazzucco, G.9
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49
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Comparison of enalapril and valsartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet
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Lassila M, Finckenberg P, Pere AK, et al. Comparison of enalapril and valsartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet. Br J Pharmacol 2000; 130:1339-1347. (Pubitemid 30488598)
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British Journal of Pharmacology
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Vapaatalo, H.6
Nurminen, M.-L.7
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