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Volumn 14, Issue 3, 2009, Pages 231-239

Management of renal dysfunction in the liver transplant recipient

Author keywords

Acute kidney injury; Calcineurin inhibitor toxicity; Chronic kidney disease; Liver transplant; Renal dysfunction

Indexed keywords

ALBUMIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIBIOTIC AGENT; BASILIXIMAB; BILIRUBIN; CALCINEURIN INHIBITOR; CYCLOSPORIN; CYCLOSPORIN A; DACLIZUMAB; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INTERLEUKIN 2 RECEPTOR BLOCKING AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RAPAMYCIN; RECEPTOR BLOCKING AGENT; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; VERAPAMIL; IMMUNOSUPPRESSIVE AGENT;

EID: 67649373847     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32832b34a4     Document Type: Review
Times cited : (39)

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    • Dubay D, Smith RJ, Qiu KG, et al. Sirolimus in liver transplant recipients with renal dysfunction offers no advantage over low-dose calcineurin inhibitor regimens. Liver Transpl 2008; 14:651-659. These authors were among the first to compare sirolimus conversion for renal preservation using a well matched CNI reduction control arm. The authors demonstrate that conversion to sirolimus in liver transplant patients with chronic renal insufficiency is associated with stabilization of renal function but confers no additional benefit to low-dose CNIs. In contrast, conversion therapy may be disadvantageous in patients with a CrCl of less than 30 ml/min. Large-scale, multicenter, randomized controlled trials are still needed.
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