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AstraZeneca's sales rise 10% in 2005 AstraZeneca plc PRESS RELEASE 2006 February 02
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AstraZeneca's sales rise 10% in 2005 AstraZeneca plc PRESS RELEASE 2006 February 02
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12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin. Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G
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12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin. Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G EUR HEART J 2006 27 9 1038-1047
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12 antagonists. van Giezen JJJ, Humphries RG
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12 antagonists. van Giezen JJJ, Humphries RG SEMIN THROMB HEMOST 2005 31 2 195-204
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SEMIN THROMB HEMOST
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12 receptor. Ding ZG, Kim S, Kunapuli SP
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12 receptor. Ding ZG, Kim S, Kunapuli SP MOL PHARMACOL 2006 69 1 338-345
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MOL PHARMACOL
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Dyspnoea after antiplatelet agents: The AZD6140 controversy. Serenbruany VL, Stebbing J, Atar D
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Dyspnoea after antiplatelet agents: The AZD6140 controversy. Serenbruany VL, Stebbing J, Atar D INT J Clin PRACT 2007 61 3 529-533
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INT J Clin PRACT
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12 receptor antagonist AZD6140 are similar for healthy Japanese and Caucasian volunteers. Ruckle JL, Winter HR, Garber S, Mitchell PD, Yoshioka T, Butler KA
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12 receptor antagonist AZD6140 are similar for healthy Japanese and Caucasian volunteers. Ruckle JL, Winter HR, Garber S, Mitchell PD, Yoshioka T, Butler KA CLIN PHARMACOL THER 2007 81 Suppl 1 S49
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CLIN PHARMACOL THER
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Multiple dose pharmacokinetics (PK) and pharmacodynamics (PD) of the reversible oral ADP receptor antagonist AZD6140. Peters G, Butler K, Winter HR, Mitchell PD
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Multiple dose pharmacokinetics (PK) and pharmacodynamics (PD) of the reversible oral ADP receptor antagonist AZD6140. Peters G, Butler K, Winter HR, Mitchell PD EUR HEART J 2006 27 Suppl 1 758
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Comparison of antiplatelet and antithrombotic effects of prasugrel and AZD6140. Ogawa T, Isobe C, Kakusaka F, Yokouchi Y, Niitsu Y, Jakubowski JA, Sugidachi A, Asai F CONGRESS INT SOC THROMB HAEMOSTASIS 2007 XXI July 10 Abs P-T-645
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Comparison of antiplatelet and antithrombotic effects of prasugrel and AZD6140. Ogawa T, Isobe C, Kakusaka F, Yokouchi Y, Niitsu Y, Jakubowski JA, Sugidachi A, Asai F CONGRESS INT SOC THROMB HAEMOSTASIS 2007 XXI July 10 Abs P-T-645
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12 antagonist AZD6140 compared with the thienopyridine, clopidogrel, in both a rat and dog model of combined thrombosis and hemostasis. Björkman JA, van Giezen JJJ, Zachrisson H CONGRESS INT SOC THROMB HAEMOSTASIS 2007 XXI July 9 Abs P-M-279
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12 antagonist AZD6140 compared with the thienopyridine, clopidogrel, in both a rat and dog model of combined thrombosis and hemostasis. Björkman JA, van Giezen JJJ, Zachrisson H CONGRESS INT SOC THROMB HAEMOSTASIS 2007 XXI July 9 Abs P-M-279
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12 by AZD6140 reduces thrombus formation and proagulation activity on collagen and atherosclerotic plaques. Kuipers MJE, Cosemans JMEM, van der Meijden REJ, Feijge MAH, Heemskerk JWM
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P-W-275
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12 by AZD6140 reduces thrombus formation and proagulation activity on collagen and atherosclerotic plaques. Kuipers MJE, Cosemans JMEM, van der Meijden REJ, Feijge MAH, Heemskerk JWM J THROMB HAEMOST 2007 5 Suppl 2 P-W-275
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AstraZeneca plc
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July 26 AstraZeneca Development Pipeline 26 July
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AstraZeneca Development Pipeline 26 July 2007 AstraZeneca plc COMPANY WORLD WIDE WEB SITE 2007 July 26
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COMPANY WORLD WIDE WEB SITE
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12 receptor antagonist for the prevention of thrombosis. Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF et al BIOORG MED CHEM LETT 2007 17 21 6013-6018.
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12 receptor antagonist for the prevention of thrombosis. Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF et al BIOORG MED CHEM LETT 2007 17 21 6013-6018.
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AZD6140 inhibits adenosine uptake into erythrocytes and enhances coronary blood flow after local ischemia or intracoronary adenosine infusion. Bjorkman JA, Kirk I, van Giezen JJ AM HEART ASSOC SCIENTIFIC SESSIONS 2007 November 04 Abs 245
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AZD6140 inhibits adenosine uptake into erythrocytes and enhances coronary blood flow after local ischemia or intracoronary adenosine infusion. Bjorkman JA, Kirk I, van Giezen JJ AM HEART ASSOC SCIENTIFIC SESSIONS 2007 November 04 Abs 245
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Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome - Primary results of the DISPERSE-2 trial. Cannon CP, Husted S, Harrington RA, Scirica BM, Emanuelsson H, Peters G, Storey RF
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Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome - Primary results of the DISPERSE-2 trial. Cannon CP, Husted S, Harrington RA, Scirica BM, Emanuelsson H, Peters G, Storey RF J AM COLL CARDIOL 2007 50 19 1844-1851
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J AM COLL CARDIOL
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12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndrome. Storey RF, Husted S, Harrington RA, Heptinstall S, Wilcox RG, Peters G, Wickens M, Emanuelsson H, Gurbel P, Grande Peer CCP
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12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndrome. Storey RF, Husted S, Harrington RA, Heptinstall S, Wilcox RG, Peters G, Wickens M, Emanuelsson H, Gurbel P, Grande Peer CCP J AM COLL CARDIOL 2007 50 19 1852-1856
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Annual Report and Form 20-F 2007, AstraZeneca, March 06
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Annual Report and Form 20-F 2007 - AstraZeneca AstraZeneca plc ANNUAL REPORT 2008 March 06
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12 receptor expressed on CHO-K1 cells. van Giezen JJ, Berntsson PS, Wissing BM
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12 receptor expressed on CHO-K1 cells. van Giezen JJ, Berntsson PS, Wissing BM ARTERIOSCLER THROMB VASC BIOL 2008 28 6 E72
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12 receptor expressed on CHO-K1 cells receptor at a site distinct form the ADP binding site but antagonizes ADP-induced signaling. van Giezen JJ, Nilsson LB ARTERIOSCLER THROMB VASC BIOL 2008 28 6 e104-e105
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12 receptor expressed on CHO-K1 cells receptor at a site distinct form the ADP binding site but antagonizes ADP-induced signaling. van Giezen JJ, Nilsson LB ARTERIOSCLER THROMB VASC BIOL 2008 28 6 e104-e105
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12 antagonist AZD6140 compared to clopidogrel and AZ11703072, a chemical compound indistinguishable from prasugrel, in both a rat and a dog model of combined thrombosis and hemostasis. van Diezen JJ, Zachrisson H, Bjorkman JA
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12 antagonist AZD6140 compared to clopidogrel and AZ11703072, a chemical compound indistinguishable from prasugrel, in both a rat and a dog model of combined thrombosis and hemostasis. van Diezen JJ, Zachrisson H, Bjorkman JA ARTERIOSCLER THROMB VASC BIOL 2008 28 6 e140
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12 receptor vs AZ11702105, a chemical compound indistinguishable from the active metabolite of prasugrel, and is a more potent inhibitor of ADP-induced platelet aggregration. van Giezen JJ, Berntsson PS ARTERIOSCLER THROMB VASC BIOL 2008 28 6 e139-e140
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12 receptor vs AZ11702105, a chemical compound indistinguishable from the active metabolite of prasugrel, and is a more potent inhibitor of ADP-induced platelet aggregration. van Giezen JJ, Berntsson PS ARTERIOSCLER THROMB VASC BIOL 2008 28 6 e139-e140
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12 receptor antagonist, administered with aspirin. Butler K, Winter H, Mitchell P, Fox J
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12 receptor antagonist, administered with aspirin. Butler K, Winter H, Mitchell P, Fox J J CLIN PHARMACOL 2007 47 9 1204
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2Q and half year results 2008. AstraZeneca plc COMPANY PRESENTATION 2008 July 31
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Daiichi Sankyo Co Ltd, Eli Lilly & Co
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FDA continues to review prasugrel new drug application, September 26
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FDA continues to review prasugrel new drug application. Daiichi Sankyo Co Ltd, Eli Lilly & Co PRESS RELEASE 2008 September 26
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(2008)
PRESS RELEASE
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Eli Lilly & Co; Daiichi Sankyo Co Ltd
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Prasugrel receives unanimous approval recommendation from FDA advisory committee, February 03
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Prasugrel receives unanimous approval recommendation from FDA advisory committee. Eli Lilly & Co; Daiichi Sankyo Co Ltd PRESS RELEASE 2009 February 03
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(2009)
PRESS RELEASE
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Eli Lilly & Co; Daiichi Sankyo Co Ltd
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European Commission approves EFIENT(R, prasugrel) for patients with acute coronary syndrome undergoing PCI, February 23
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European Commission approves EFIENT(R) (prasugrel) for patients with acute coronary syndrome undergoing PCI. Eli Lilly & Co; Daiichi Sankyo Co Ltd PRESS RELEASE 2009 February 23
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PRESS RELEASE
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12 antagonism: Promises and challenges. Michelson AD ARTERIOSCLER THROMB VASC BIOL 2008 28 3 s33-s38
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12 antagonism: Promises and challenges. Michelson AD ARTERIOSCLER THROMB VASC BIOL 2008 28 3 s33-s38
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Single doses of AZD6140 900 mg do not prolong the QT interval in healthy subjects. Butler K, Wei C, Teng R PHARMACOL THER 2009 85 Suppl 1 S20
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Single doses of AZD6140 900 mg do not prolong the QT interval in healthy subjects. Butler K, Wei C, Teng R PHARMACOL THER 2009 85 Suppl 1 S20
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Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Storey RF, Oldroyd KG, Wilcox RG THROMB HAEMOST 2001 85 3 401-407
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Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): Double-blind, randomized controlled trial. Montalescot G, Wiviott SD, Braunwald E, Murphy SA, Gibson CM, McCabe CH, Antman EM LANCET 2009 373 723-731
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Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Peters RJ, Mehta SR, Fox KA, Zhao F, Lewis BS, Kopecky SL, Diaz R, Commerford PJ, Valentin V, Yusus S CIRCULATION 2003 108 14 1682-1687
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Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model. Dai J, Louedec L, Philippe M, Michel JB, Houard X J VASC SURG 2009 49 3 719-727
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Daichii and Lilly launch prasugrel in UK for ACS-PCI Daiichi Sankyo Co Ltd, April 08
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Daichii and Lilly launch prasugrel in UK for ACS-PCI Daiichi Sankyo Co Ltd PRESS RELEASE 2009 April 08
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(2009)
PRESS RELEASE
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