Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: Enzymatic inhibition assay with crystal structural and thermodynamic characterization

BMC Microbiology

Volumn 9, Issue , 2009, Pages

  Chen, Jing ^a   Zhang, Liang ^a   Zhang, Yu ^a   Zhang, Haitao ^a   Du, Jiamu ^b   Ding, Jianping ^a,b   Guo, Yuewei ^a   Jiang, Hualiang ^a   Shen, Xu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA HYDROXYACYL ACYL CARRIER PROTEIN DEHYDRATASE; EMODIN; UNCLASSIFIED DRUG; BETA HYDROXYACYL (ACYL CARRIER PROTEIN)DEHYDRASE; BETA-HYDROXYACYL-(ACYL-CARRIER-PROTEIN)DEHYDRASE; ENZYME INHIBITOR; HYDROLYASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; ASSAY; BACTERIAL GROWTH; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME INHIBITION; HELICOBACTER PYLORI; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PROTEIN TARGETING; SURFACE PLASMON RESONANCE; THERMODYNAMICS; CALORIMETRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYMOLOGY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

BACTERIAL PROTEINS; CALORIMETRY; CATALYTIC DOMAIN; EMODIN; ENZYME INHIBITORS; HELICOBACTER PYLORI; HYDRO-LYASES; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 67649317326     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-9-91     Document Type: Article

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