Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients

Journal of Vascular Surgery

Volumn 50, Issue 1, 2009, Pages 100-106

  Martin, Myriam ^a   Gottsäter, Anders ^b   Nilsson, Peter M ^b   Mollnes, Tom E ^c   Lindblad, Bengt ^b   Blom, Anna M ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTIBIOTIC AGENT; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C4B BINDING PROTEIN; COMPLEMENT COMPONENT C5B; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN; NEOPTERIN; PROSTAGLANDIN F2 ALPHA; TUMOR NECROSIS FACTOR ALPHA; WARFARIN;

AGED; AMPUTATION; ANKLE PRESSURE; ARTICLE; BLOOD PRESSURE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GANGRENE; HOSPITAL ADMISSION; HUMAN; LEUKOCYTE COUNT; LIMB ISCHEMIA; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SIDE EFFECT; THROMBOCYTE COUNT;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; COMPLEMENT ACTIVATION; COMPLEMENT C4B-BINDING PROTEIN; FEMALE; HUMANS; ISCHEMIA; MALE; PERIPHERAL VASCULAR DISEASES; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 67649236801     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2008.12.033     Document Type: Article

References (34)

1. Norgren L., Hiatt W.R., Dormandy J.A., Nehler M.R., Harris K.A., and Fowkes F.G. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg 45 Suppl S (2007) S5-S67
2. Novo S., Coppola G., and Milio G. Critical limb ischemia: definition and natural history. Curr Drug Targets Cardiovasc Haematol Disord 4 (2004) 219-225
3. Gottsater A. Managing risk factors for atherosclerosis in critical limb ischemia. Eur J Vasc Endovasc Surg 32 (2006) 478-483
4. Landry G.J. Functional outcome of critical limb ischemia. J Vasc Surg 45 Suppl A (2007) A141-A148
5. Walport M.J. Complement. First of two parts. N Engl J Med 344 (2001) 1058-1066
6. Dahlback B. The tale of protein S and C4b-binding protein, a story of affection. Thromb Haemost 98 (2007) 90-96
7. Hillarp A., and Dahlbäck B. Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. Proc Natl Acad Sci USA 87 (1990) 1183-1187
8. Kask L., Hillarp A., Ramesh B., Dahlback B., and Blom A.M. Structural requirements for the intracellular subunit polymerization of the complement inhibitor C4b-binding protein. Biochemistry 41 (2002) 9349-9357
9. Saeki T., Hirose S., Nukatsuka M., Kusunoki Y., and Nagasawa S. Evidence that C4b-binding protein is an acute phase protein. Biochem Biophys Res Commun 164 (1989) 1446-1451
10. Garcia de Frutos P., Alim R.I., Hardig Y., Zoller B., and Dahlback B. Differential regulation of alpha and beta chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S. Blood 84 (1994) 815-822
11. Criado Garcia O., Sanchez-Corral P., and Rodriguez de Cordoba S. Isoforms of human C4b-binding protein. II. Differential modulation of the C4BPA and C4BPB genes by acute phase cytokines. J Immunol 155 (1995) 4037-4043
12. Trouw L.A., Nilsson S.C., Goncalves I., Landberg G., and Blom A.M. C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation. J Exp Med 201 (2005) 1937-1948
13. Webb J.H., Blom A.M., and Dahlbäck B. Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells. J Immunol 169 (2002) 2580-2586
14. Nilsson P., and Berglund G. Prevention of cardiovascular disease and diabetes: lessons from the Malmo Preventive Project. J Intern Med 248 (2000) 455-462
15. Barani J., Nilsson J.A., Mattiasson I., Lindblad B., and Gottsater A. Inflammatory mediators are associated with 1-year mortality in critical limb ischemia. J Vasc Surg 42 (2005) 75-80
16. Mollnes T.E., Lea T., Froland S.S., and Harboe M. Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex. Scand J Immunol 22 (1985) 197-202
17. Mollnes T.E., Redl H., Hogasen K., Bengtsson A., Garred P., Speilberg L., et al. Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC). Clin Exp Immunol 91 (1993) 295-300
18. Trouw L.A., Bengtsson A.A., Gelderman K.A., Dahlback B., Sturfelt G., and Blom A.M. C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack. J Biol Chem 282 (2007) 28540-28548
19. Funakoshi M., Sasaki J., and Arakawa K. Proline-rich protein is a glycoprotein and an acute phase reactant. Biochim Biophys Acta 963 (1988) 98-108
20. Phillips D.J., Novinger M.S., Evatt B.L., and Hooper W.C. TNF-alpha suppresses IL-1 alpha and IL-6 upregulation of C4b-binding protein in HepG-2 hepatoma cells. Thromb Res 81 (1996) 307-314
21. Albrecht E.A., Chinnaiyan A.M., Varambally S., Kumar-Sinha C., Barrette T.R., Sarma J.V., et al. C5a-induced gene expression in human umbilical vein endothelial cells. Am J Pathol 164 (2004) 849-859
22. Riedemann N.C., Neff T.A., Guo R.F., Bernacki K.D., Laudes I.J., Sarma J.V., et al. Protective effects of IL-6 blockade in sepsis are linked to reduced c5a receptor expression. J Immunol 170 (2003) 503-507
23. Marcovina S.M., Zoppo A., Vigano-D'Angelo S., Di Cola G., and D'Angelo A. Determination of serum levels of complement component C4b-binding protein: influence of age and inflammation. Int J Clin Lab Res 21 (1991) 171-175
24. Torzewski J., Torzewski M., Bowyer D.E., Frohlich M., Koenig W., Waltenberger J., et al. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol 18 (1998) 1386-1392
25. Sjoberg A.P., Trouw L.A., McGrath F.D., Hack C.E., and Blom A.M. Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. J Immunol 176 (2006) 7612-7620
26. Jarva H., Jokiranta T.S., Hellwage J., Zipfel P.F., and Meri S. Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11. J Immunol 163 (1999) 3957-3962
27. Del Conde I., Cruz M.A., Zhang H., Lopez J.A., and Afshar-Kharghan V. Platelet activation leads to activation and propagation of the complement system. J Exp Med 201 (2005) 871-879
28. Polley M.J., and Nachman R. The human complement system in thrombin-mediated platelet function. J Exp Med 147 (1978) 1713-1726
29. Wiedmer T., Esmon C.T., and Sims P.J. Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase. Blood 68 (1986) 875-880
30. Xu N., Dahlback B., Ohlin A.K., and Nilsson A. Association of vitamin K-dependent coagulation proteins and C4b binding protein with triglyceride-rich lipoproteins of human plasma. Arterioscler Thromb Vasc Biol 18 (1998) 33-39
31. Kimoto K., Inoue T., Oku K., Mori T., Kusuda M., Handa K., et al. Relation of C4b-binding protein to athero-sclerosis of the descending thoracic aorta. Artery 22 (1996) 101-114
32. Bismuth J., Kofoed S.C., Jensen A.S., Sethi A., and Sillesen H. Serum lipids act as inverse acute phase reactants and are falsely low in patients with critical limb ischemia. J Vasc Surg 36 (2002) 1005-1010
33. Zöller B., Garcia de Frutos P., and Dahlbäck B. Evaluation of the relationship between protein S and C4b-binding protein isoforms in hereditary protein S deficiency demonstrating type I and type III deficiencies to be phenotypic variants of the same genetic disease. Blood 85 (1995) 3524-3531
34. Takahashi H., Wada K., Hayashi S., Hanano M., Tatewaki W., and Shibata A. Behavior of protein S during long-term oral anticoagulant therapy. Thromb Res 51 (1988) 241-249