Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

International Journal of Impotence Research

Volumn 21, Issue 3, 2009, Pages 192-197

  Justo, D ^a,b   Mashav, N ^a   Arbel, Y ^a   Kinori, M ^a   Steinvil, A ^a   Swartzon, M ^a   Molat, B ^a   Halkin, A ^a   Finkelstein, A ^a   Heruti, R ^a   Banai, S ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Coronary artery disease; Erectile dysfunction; Erythrocyte aggregation

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; THIAZIDE DIURETIC AGENT;

ADULT; AGE DISTRIBUTION; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD SMEAR; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE SEVERITY; ERECTILE DYSFUNCTION; ERYTHROCYTE; ERYTHROCYTE AGGREGATION; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUESTIONNAIRE; SEXUAL HEALTH; BLOOD; BLOOD CELL COUNT; BODY MASS; COHORT ANALYSIS; HEALTH SURVEY; ISRAEL; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SEXUALITY; SOCIOECONOMICS;

ADULT; AGED; AGED, 80 AND OVER; BLOOD CELL COUNT; BODY MASS INDEX; COHORT STUDIES; CORONARY ARTERY DISEASE; DIABETES MELLITUS; ERECTILE DYSFUNCTION; ERYTHROCYTE AGGREGATION; HEALTH SURVEYS; HEMATOCRIT; HEMOGLOBINS; HUMANS; ISRAEL; MALE; MIDDLE AGED; SEXUALITY; SOCIOECONOMIC FACTORS;

EID: 67649220666     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2009.6     Document Type: Article

References (37)

1. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, Salonia A et al. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005; 96: 19M-23M.
2. Kirby M, Jackson G, Simonsen U. Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 2005; 59: 225-229.
3. Stoltz JF, Donner M, Larcan A. Introduction to hemorheology: theoretical aspects and hyperviscosity syndromes. Int Angiol 1987; 6: 119-132.
4. Vlachopoulos C, Aznaouridis K, Ioakeimidis N, Rokkas K, Vasiliadou C, Alexopoulos N et al. Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease. Eur Heart J 2006; 27: 2640-2648.
5. Pryor J, Akkus E, Alter G, Jordan G, Lebret T, Levine L et al. Priapism. J Sex Med 2004; 1: 116-120.
6. Burnett AL, Allen RP, Tempany CM, Dover GJ, Brendler CB. Evaluation of erectile function in men with sickle cell disease. Urology 1995; 45: 657-663.
7. Bodie J, Lewis J, Schow D, Monga M. Laboratory evaluations of erectile dysfunction: an evidence based approach. JUrol 2003;169: 2262-2264.
8. Crook L, Liu PI, Gadsden RH, Turner III RE. Erythrocyte sedimentation, viscosity, and plasma proteins in disease detection. Ann Clin Lab Sci 1980; 10: 368-376.
9. Nurkalem Z, Kaya C, Orhan AL, Zencirci E, Alper AT, Kucuk E et al. Erectile dysfunction and coronary slow flow: distinct presentations of endothelial disease. Int J Impot Res 2007; 19:610-614.
10. Mchedlishvili G. Disturbed blood flow structuring as critical factor of hemorheological disorders in microcirculation. Clin Hemorheol Microcirc 1998; 19: 315-325.
11. Peled N, Kassirer M, Kramer MR, Rogowski O, Shlomi D, Fox B et al. Increased erythrocyte adhesiveness and aggregation in obstructive sleep apnea syndrome. Thromb Res 2008; 121:631-636.
12. Samocha-Bonet D, Ben-Ami R, Shapira I, Shenkerman G, Abu- Abeid S, Stern N et al. Flow-resistant red blood cell aggregation in morbid obesity. Int J Obes Relat Metab Disord 2004; 28: 1528-1534.
13. Toker S, Rogowski O, Melamed S, Shirom A, Shapira I, Berliner S et al. Association of components of the metabolic syndrome with the appearance of aggregated red blood cells in the peripheral blood. An unfavorable hemorheological finding. Diabetes Metab Res Rev 2005; 21: 197-202.
14. Zeltser D, Serov J, Mardi T, Rogowski O, Tulshinski T, Goldin Y et al. Serum lipids as minor determinants of the degree of erythrocyte adhesiveness/aggregation in the peripheral blood of individuals with low grade inflammation and moderately increased serum lipids. Clin Hemorheol Microcirc 2004; 31:161-167.
15. Fusman R, Rotstein R, Elishkewich K, Zeltser D, Cohen S, Kofler M et al. Image analysis for the detection of increased erythrocyte, leukocyte and platelet adhesiveness/aggregation in the peripheral blood of patients with diabetes mellitus. Acta Diabetol 2001; 38: 129-134.
16. Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G. Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 2005;172: 613-618.
17. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004; 169: 348-353.
18. Bonora E. The metabolic syndrome and cardiovascular disease. Ann Med 2006; 38: 64-80.
19. Corona G, Mannucci E, Petrone L, Schulman C, Balercia G, Fisher AD et al. A comparison of NCEP-ATPIII and IDF metabolic syndrome definitions with relation to metabolic syndrome-associated sexual dysfunction. J Sex Med 2007; 4:789-796.
20. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, PenaBM. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int JImpot Res 1999;11: 319-326.
21. Fusman R, Zeltser D, Rotstein R, Chapman J, Avitzour D, Shapira I I et al. INFLAMET: an image analyzer to display erythrocyte adhesiveness/ aggregation. Eur JIntern Med 2000;11: 271-276.
22. Clauss A. Rapid physiological coagulation method in determination of fibrinogen. Acta Haematol 1957; 17: 237-246.
23. Rogowski O, Vered Y, Shapira I, Hirsh M, Zakut V, Berliner S. Introducing the wide range C-reactive protein (wr-CRP) into clinical use for the detection of microinflammation. Clin Chim Acta 2005; 358: 151-158.
24. NIH consensus development panel on impotence. JAMA 1993;270: 83-90.
25. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-61.
26. Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003; 44: 360-364.
27. Gazzaruso C, Solerte SB, Pujia A, Coppola A, Vezzoli M, Salvucci F et al. Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phospho- diesterase inhibitors. JAm Coll Cardiol 2008; 51: 2040-2044.
28. Foroutan SK, Rajabi M. Erectile dysfunction in men with angiographically documented coronary artery disease. Urol J 2007; 4: 28-32.
29. Ami RB, Barshtein G, Zeltser D, Goldberg Y, Shapira I, Roth A et al. Parameters of red blood cell aggregation as correlates of the inflammatory state. Am JPhysiol Heart Circ Physiol 2001;280: H1982-H1988.
30. Berliner S, Rogowski O, Aharonov S, Mardi T, Tolshinsky T, Rozenblat M et al. Erythrocyte adhesiveness/aggregation: a novel biomarker for the detection of low-grade internal inflammation in individuals with atherothrombotic risk factors and proven vascular disease. Am Heart J 2005; 149:260-267.
31. Rotstein R, Landau T, Twig A, Rubinstein A, Koffler M, Justo D et al. The erythrocyte adhesiveness/aggregation test (EAAT). A new biomarker to reveal the presence of low grade subclinical smoldering inflammation in individuals with atherosclerotic risk factors. Atherosclerosis 2002; 165: 343-351.
32. Assayag EB, Bova I, Kesler A, Berliner S, Shapira I, Bornstein NM. Erythrocyte aggregation as an early biomarker in patients with asymptomatic carotid stenosis. Dis Markers 2008; 24: 33-39.
33. Shapira I, Rotstein R, Fusman R, Gluzman B, Roth A, Keren G et al. Combined leukocyte and erythrocyte aggregation in patients with acute myocardial infarction. Int J Cardiol 2001;78: 299-305.
34. Shenhar-Tsarfaty S, Assayag EB, Bova I, Shopin L, Berliner S, Shapira I et al. Early signaling of inflammation in acute ischemic stroke: clinical and rheological implications. Thromb Res 2008; 122: 167-173.
35. Bocchio M, Desideri G, Scarpelli P, Necozione S, Properzi G, Spartera C et al. Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. J Urol 2004; 171: 1601-1604.
36. Fornal M, Korbut RA, Lekka M, Pyka-Fooeciak G, Wizner B, Styczen J et al. Rheological properties of erythrocytes in patients with high risk of cardiovascular disease. Clin Hemorheol Microcirc 2008; 39: 213-219.
37. Muravyov AV, Yakusevich VV, Surovaya L, Petrochenko A. The effect of simvastatin therapy on hemorheological profile in coronary heart disease (CHD) patients. Clin Hemorheol Microcirc 2004; 31: 251-256.