Serum β2-microglobulin measured by immunonephelometry: Expression patterns and reference intervals in healthy adults

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 5, 2009, Pages 585-589

  Mátrai, Zoltán ^a   Németh, Júlia ^b   Miklós, Katalin ^b   Szabó, Zsófia ^b   Masszi, Tamás ^a  

^a Szent Laszlo Hospital   (Hungary)

^b State Health Center   (Hungary)

Author keywords

2 microglobulin ( 2m); Age; Immunonephelometry; Reference interval

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; FEMALE; GROUPS BY AGE; HUMAN; IMMUNOASSAY; IMMUNONEPHELOMETRY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REFERENCE VALUE; AGING; BLOOD; COHORT ANALYSIS; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PHOTOMETRY; SEX DIFFERENCE;

ADULT; AGED; AGING; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; COHORT STUDIES; FEMALE; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; REFERENCE VALUES; SEX FACTORS; STATISTICS, NONPARAMETRIC;

EID: 67649210075     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.137     Document Type: Article

References (43)

1. Cunningham BA, Berggård I. Structure, evolution and significance of beta-2-microglobulin. Transplant Rev 1974;21: 3-14.
2. Berggård I, Bearn AG. Isolation and properties of a low molecular weight beta-2-globulin occurring in human biological fluids. J Biol Chemistry 1968;243:4095-103.
3. Cresswell P, Springer T, Strominger JL, Turner MJ, Grey HM, Kubo RT. Immunological identity of the small sub-unit of HL-A antigens and beta-2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci USA 1974;71:2123-7.
4. Wibell L, Evrin PE, Berggård I. Serum beta-2-microglobulin in renal disease. Nephron 1973;10:320-31.
5. Teasdale C, Mander AM, Fifield R, Keyser JW, Newcombe RG, Hughes LE. Serum beta-2-microglobulin in controls and cancer patients. Clin Chim Acta 1977;78:135-43.
6. Beta 2-microglobulin in hematological malignancies (Editorial) Br Med J 1981;282:1013.
7. Font J, Coca A, Molina R, Ballesta A, Cardellach F, Ingelmo M, et al. Serum beta 2-microglobulin as a marker of activity in systemic lupus erythematosus. Scand J Rheumatol 1986;15:201-5.
8. Fahey JL, Taylor JM, Detels R, Hofmann B, Melmed R, Nishanian P, et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 1990;322:166-72.
9. Bataille R, Grenier J, Sany J. Beta 2-microglobulin in myeloma: optimal use for staging, prognosis, and treatment - a prospective study of 160 patients. Blood 1984;63: 468-76.
10. Greipp PR, San Miguel J, Durie BG, Crowley JJ, Barlogie B, Blade J, et al. International staging system for multiple myeloma. J Clin Oncol 2005;23:3412-20.
11. Späti B, Child JA, Kerruish SM, Cooper EH. Behaviour of serum beta 2-microglobulin and acute phase reactant proteins in chronic lymphocytic leukaemia. A multi-centre study. Acta Haematol 1980;64:79-86.
12. 2-microglobulin level is more powerful than stage in predicting response and survival in chronic lym-phocytic leukaemia. Blood 1995;86(suppl 1), Abstr. 606.
13. Child JA, Spati B, Illingworth S, Barnard D, Corbett S, Simmons AV, et al. Serum beta-2-microglobulin and C-reactive protein in the monitoring of lymphomas: findings in a multicenter study and experience in selected patients. Cancer 1980;45:318-26.
14. Wierda WG, O'Brien S, Wang X, Faderl S, Ferrajoli A, Do KA, et al. Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia. Blood 2007;109:4679-85.
15. Swan F Jr, Velasquez WS, Tucker S, Redman JR, Rodriguez MA, McLaughlin P, et al. A new serologic staging system for large-cell lymphomas based on initial beta 2-microglobulin and lactate dehydrogenase levels. J Clin Oncol 1989;7:1518-27.
16. Evrin PE, Wibell L. The serum levels and urinary excretion of beta 2-microglobulin in apparently healthy subjects. Scand J Clin Lab Invest 1972;29:69-74.
17. Swanson RA, Tracy RP, Katzmann JA, Wilson DM, Young DS. Beta 2-microglobulin determined by radio-immunoassay with monoclonal antibody. Clin Chem 1982;28:2033-9.
18. Woo J, Floyd M, Longley MA, Cannon DC. Beta 2-microglobulin clearance as measured by radioimmunoassay. Clin Chem 1980;26:1193-7.
19. Diamondstone LS, Tollerud DJ, Fuchs D, Wachter H, Brown LM, Maloney E, et al. Factors influencing serum neopterin and beta 2-microglobulin levels in a healthy diverse population. J Clin Immunol 1994;14:368-74.
20. Bernard AM, Vyskocil A, Lauwerys RR. Determination of beta 2-microglobulin in human urine and serum by latex immunoassay. Clin Chem 1981;27:832-7.
21. Viedma JA, Pacheco S, Albaladejo MD. Determination of beta 2-microglobulin in serum by a microparticle-enhanced nephelometric immunoassay. Clin Chem 1992;38:2464-8.
22. Filippin FB, Souza LC. Serum beta 2-microglobulin values among healthy Brazilians using a DPC immulite assay. Clinics 2005;60:47-50.
23. Johnson AM, Hyltoft Petersen P, Whicher JT, Carlström A, MacLennan S. International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Plasma Proteins. Reference intervals for serum proteins: similarities and differences between adult Caucasian and Asian Indian males in Yorkshire, UK. Clin Chem Lab Med 2004;42:792-9.
24. Evrin PE, Peterson PA, Wide L, Berggård I. Radioimmunoassay of beta-2-microglobulin in human biological fluids. Scand J Clin Lab Invest 1971;28:439-43.
25. Bjerrum OW, Birgens HS. Measurement of beta 2-microglobulin in serum and plasma by an enzyme-linked immunosorbent assay (ELISA). Clin Chim Acta 1986; 155:69-76.
26. Medcalf EA, Newman DJ, Gilboa A, Gorman EG, Price CP. A rapid and robust particle-enhanced turbidimetric immunoassay for serum beta 2-microglobulin. J Immunol Methods 1990;129:97-103.
27. O'Reilly D, Whicher J, Sanderson AR. A simple, precise and sensitive nephelometric assay for beta 2-microglobulin in body fluids. J Immunol Methods 1983;57:265-73.
28. Rifai N, Morales A. Immunoturbidimetry of beta 2-microglobulin in serum. Clin Chem 1989;35:1996-7.
29. Bernard AM, Lauwerys RR. Comparison of turbidimetry with particle counting for the determination of human beta 2-microglobulin by latex immunoassay (LIA). Clin Chim Acta 1982;119:335-9.
30. Wu JT, Clayton F, Myers S, Knight J. A simple radial immunodiffusion method for assay of beta 2-microglobulin in serum. Clin Chem 1986;32:2070-3.
31. Solberg HE. International Federation of Clinical Chemistry, Expert Panel on Theory of Reference Values, and International Committee for Standardization in Haema-tology, Standing Committee on Reference Values. Approved recommendation (1987) on the theory of reference values. Part 5. Statistical treatment of collected reference values. Determination of reference limits. J Clin Chem Clin Biochem 1987;25:645-56. Clin Chim Acta 1987;170:S13-32.
32. Solberg HE. The IFCC recommendation on estimation of reference intervals. The RefVal Program. Clin Chem Lab Med 2004;42:710-4.
33. NCCLS. How to define and determine reference intervals in the clinical laboratory; Approved Guideline, 2nd ed. NCCLS document C28-A2. NCCLS, 940 West Walley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2000.
34. Harris EK, Boyd JC. On dividing reference data into subgroups to produce separate reference ranges. Clin Chem 1990;36:265-70.
35. Lahti A. Partitioning biochemical reference data into subgroups: comparison of existing methods. Clin Chem Lab Med 2004;42:725-33.
36. Klee GG. Clinical interpretation of reference intervals and reference limits. A plea for assay harmonization. Clin Chem Lab Med 2004;42:752-7.
37. Henny J, Petitclerc C, Fuentes-Arderiu X, Petersen PH, Queraltó JM, Schiele F, et al. Need for revisiting the concept of reference values. Clin Chem Lab Med 2000;38: 589-95.
38. Petitclerc C. Normality: the unreachable star? Clin Chem Lab Med 2004;42:698-701.
39. Zweig MH, Campbell G. Receiver operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine. Clin Chem 1993;39:561-77.
40. Torsten H. On the exact distribution of maximally selected rank statistics. Computational statistics and data analysis 2003;43:121-38.
41. Ibrahim S, Keating M, Do KA, O'Brien S, Huh YO, Jilani I, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia Blood 2001; 98:181-6.
42. Koller C, Bekele BN, Zhou X, Park C, Estrov Z, O'Brien S, et al. Plasma thromboprotein compared with immunoglobulin heavy-chain mutation status as a predictor of survival in chronic lymphocytic leukemia. Blood 2006; 108:1001-6.
43. Wierda WG, Johnson MM, Do KA, Manshouri T, Dey A, O'Brien S, et al. Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia. Br J Haematol 2003;120:452-6.