Immediate and Delayed Reactions to Radiocontrast Media: Is There an Allergic Mechanism?

Immunology and Allergy Clinics of North America

Volumn 29, Issue 3, 2009, Pages 453-468

  Brockow, Knut ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Diagnosis; Hypersensitivity; Immediate; Mechanism; Non immediate; Radiocontrast media; Skin test

Indexed keywords

BRADYKININ; CD4 ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; COMPLEMENT; CONTRAST MEDIUM; CORTICOSTEROID; CYCLOSPORIN; DIMERIC IONIC CONTRAST MEDIUM; DIMERIC NONIONIC CONTRAST MEDIUM; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; HLA DR ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 2 RECEPTOR ALPHA; METHYLPREDNISOLONE; MONOMERIC IONIC CONTRAST MEDIUM; MONOMERIC NONIONIC CONTRAST MEDIUM;

ANAPHYLAXIS; BASOPHIL; CARDIOLOGIST; CELL ACTIVATION; CLINICAL FEATURE; DELAYED HYPERSENSITIVITY; DRUG HYPERSENSITIVITY; DRUG SAFETY; HISTAMINE RELEASE; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOASSAY; IN VITRO STUDY; INTRACUTANEOUS TEST; MEDICAL DECISION MAKING; MEDICAL RESEARCH; PATCH TEST; PATHOPHYSIOLOGY; PREDICTION; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; RADIOLOGIST; RASH; REVIEW; SKIN TEST; T LYMPHOCYTE; TIME;

ANIMALS; CONTRAST MEDIA; DRUG HYPERSENSITIVITY; HUMANS; HYPERSENSITIVITY, DELAYED; HYPERSENSITIVITY, IMMEDIATE; OCCUPATIONAL EXPOSURE; PRACTICE GUIDELINES AS TOPIC; RADIOGRAPHY; SKIN TESTS;

EID: 67649203500     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.iac.2009.04.001     Document Type: Review

References (83)

1. Christiansen C. X-ray contrast media: an overview. Toxicology 209 (2005) 185-187
2. Brockow K., Christiansen C., Kanny G., et al. Management of hypersensitivity reactions to iodinated contrast media. Allergy 60 (2005) 150-158
3. Brockow K., Romano A., Aberer W., et al. Skin testing in patients with hypersensitivity reactions to iodinated contrast media: a European multicenter study. Allergy 64 (2009) 234-241
4. Christiansen C., Dreborg S., Pichler W.J., et al. Macular exanthema appearing 5 days after x-ray contrast medium administration. Eur Radiol 3 Suppl 12 (2002) S94-S97
5. Kvedariene V., Martins P., Rouanet L., et al. Diagnosis of iodinated contrast media hypersensitivity: results of a 6-year period. Clin Exp Allergy 36 (2006) 1072-1077
6. Romano A., Artesani M., Andriolo M., et al. Effective prophylactic protocol in delayed hypersensitivity to contrast media: report of a case involving lymphocyte transformation studies with different compounds. Radiology 225 (2002) 466-470
7. Vernassiere C., Trechot P., Commun N., et al. Low negative predictive value of skin tests in investigating delayed reactions to radiocontrast media. Contact Derm 50 (2004) 359-366
8. Brockow K., Becker E.W., Worret W.I., et al. Late skin test reactions to radiocontrast medium. J Allergy Clin Immunol 104 (1999) 1107-1108
9. Kanny G., Pichler W., Morisset M., et al. T cell-mediated reactions to iodinated contrast media: evaluation by skin and lymphocyte activation tests. J Allergy Clin Immunol 115 (2005) 179-185
10. Arnold A.W., Hausermann P., Bach S., et al. Recurrent flexural exanthema (SDRIFE or baboon syndrome) after administration of two different iodinated radiocontrast media. Dermatology 214 (2007) 89-93
11. Laroche D. Immediate reactions to contrast media: mediator release and value of diagnostic testing. Toxicology 209 (2005) 193-194
12. Brockow K., Kiehn M., Kleinheinz A., et al. Positive skin tests in late reactions to radiographic contrast media. Allerg Immunol (Paris) 31 (1999) 49-51
13. Lerch M., Keller M., Britschgi M., et al. Cross-reactivity patterns of T cells specific for iodinated contrast media. J Allergy Clin Immunol 119 (2007) 1529-1536
14. Torres M.J., Mayorga C., Cornejo-Garcia J.A., et al. Monitoring non-immediate allergic reactions to iodine contrast media. Clin Exp Immunol 152 (2008) 233-238
15. Mita H., Tadokoro K., and Akiyama K. Detection of IgE antibody to a radiocontrast medium. Allergy 53 (1998) 1133-1140
16. Brockow K. Contrast media hypersensitivity: scope of the problem. Toxicology 209 (2005) 189-192
17. Gueant-Rodriguez R.M., Romano A., Barbaud A., et al. Hypersensitivity reactions to iodinated contrast media. Curr Pharm Des 12 (2006) 3359-3372
18. Katayama H., Yamaguchi K., Kozuka T., et al. Adverse reactions to ionic and nonionic contrast media: a report from the Japanese committee on the safety of contrast media. Radiology 175 (1990) 621-628
19. Wolf G.L., Arenson R.L., and Cross A.P. A prospective trial of ionic versus nonionic contrast agents in routine clinical practice: comparison of adverse effects. AJR Am J Roentgenol 152 (1989) 939-944
20. Palmer F.J. The RACR survey of intravenous contrast media reactions: final report. Australas Radiol 32 (1988) 426-428
21. Caro J.J., Trindade E., and McGregor M. The risks of death and of severe nonfatal reactions with high- vs low-osmolality contrast media: a meta-analysis. AJR Am J Roentgenol 156 (1991) 825-832
22. Webb J.A., Stacul F., Thomsen H.S., et al. Late adverse reactions to intravascular iodinated contrast media. Eur Radiol 13 (2003) 181-184
23. Munechika H., Yasuda R., and Michihiro K. Delayed adverse reaction of monomeric contrast media: comparison of plain CT and enhanced CT. Acad Radiol 1 Suppl 5 (1998) S157-S158
24. Yasuda R., and Munechika H. Delayed adverse reactions to nonionic monomeric contrast-enhanced media. Invest Radiol 33 (1998) 1-5
25. Hosoya T., Yamaguchi K., Akutsu T., et al. Delayed adverse reactions to iodinated contrast media and their risk factors. Radiat Med 18 (2000) 39-45
26. Sutton A.G., Finn P., Grech E.D., et al. Early and late reactions after the use of iopamidol 340, ioxaglate 320, and iodixanol 320 in cardiac catheterization. Am Heart J 141 (2001) 677-683
27. Kalimo K., Jansen C.T., and Kormano M. Allergological risk factors as predictors of radiographic contrast media hypersensitivity. Ann Allergy 45 (1980) 253-255
28. Choyke P.L., Miller D.L., Lotze M.T., et al. Delayed reactions to contrast media after interleukin-2 immunotherapy. Radiology 183 (1992) 111-114
29. Witten J., Hirsch F., and Hartman G. Acute reactions to urographic contrast medium. Am J Roentgenol 119 (1973) 832-840
30. Idee J.M., Pines E., Prigent P., et al. Allergy-like reactions to iodinated contrast agents: a critical analysis. Fundam Clin Pharmacol 19 (2005) 263-281
31. Ring J., and Messmer K. Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1 (1977) 466-469
32. Vavricka S.R., Halter J., Furrer K., et al. Contrast media triggering cutaneous graft-vs-host disease. Bone Marrow Transplant 29 (2002) 899-901
33. Belhadjali H., Bouzgarrou L., Youssef M., et al. DRESS syndrome induced by sodium meglumine ioxitalamate. Allergy 63 (2008) 786-787
34. Laffitte E., Nenadov Beck M., Hofer M., et al. Severe Stevens-Johnson syndrome induced by contrast medium iopentol (Imagopaque). Br J Dermatol 150 (2004) 376-378
35. Goodfellow T., Holdstock G.E., Brunton F.J., et al. Fatal acute vasculitis after high-dose urography with iohexol. Br J Radiol 59 (1986) 620-621
36. Savill J.S., Barrie R., Ghosh S., et al. Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus. Postgrad Med J 64 (1988) 392-394
37. Schmidt B.J., Foley W.D., and Bohorfoush A.G. Toxic epidermal necrolysis related to oral administration of diluted diatrizoate meglumine and diatrizoate sodium. AJR Am J Roentgenol 171 (1998) 1215-1216
38. Rosado A., Canto G., Veleiro B., et al. Toxic epidermal necrolysis after repeated injections of iohexol. AJR Am J Roentgenol 176 (2001) 262-263
39. Miranda-Romero A., Sanchez-Sambucety P., Esquivias Gomez J.I., et al. Vegetating iododerma with fatal outcome. Dermatology 198 (1999) 295-297
40. Vaillant L., Pengloan J., Blanchier D., et al. Iododerma and acute respiratory distress with leucocytoclastic vasculitis following the intravenous injection of contrast medium. Clin Exp Dermatol 15 (1990) 232-233
41. Savader S., Brodkin J., and Osterman F. Delayed life-threatening reaction to non-ionic contrast media. Invest Radiol 10 (1995) 115-116
42. Miamoto Y., Tatei T., Ichijima S., et al. [Delayed eruption caused with non-ionic contrast material injection]. Nippon Igaku Hoshasen Gakkai Zaschi 50 3 (1990) 295-297 [in Japanese]
43. Ring J., Arroyave C.M., Frizler M.J., et al. In vitro histamine and serotonin release by radiographic contrast media (RCM): complement-dependent and -independent release reaction and changes in ultrastructure of human blood cells. Clin Exp Immunol 32 (1978) 105-118
44. Lasser E.C., and Lyon S.G. Inhibition of angiotensin-converting enzyme by contrast media. I. In vitro findings. Invest Radiol 25 6 (1990) 698-702
45. Krause W., and Niehues D. Biochemical characterization of x-ray contrast media. Invest Radiol 31 (1996) 30-42
46. Amon E.U., Ennis M., Schnabel M., et al. Radiographic contrast media-induced histamine release: a comparative study with mast cells from different species. Agents Actions 27 (1989) 104-106
47. Stellato C., de Crescenzo G., Patella V., et al. Human basophil/mast cell releasability. XI. Heterogeneity of the effects of contrast media on mediator release. J Allergy Clin Immunol 97 (1996) 838-850
48. Laroche D., Aimone-Gastin I., Dubois F., et al. Mechanisms of severe, immediate reactions to iodinated contrast material. Radiology 209 (1998) 183-190
49. Westaby S., Dawson P., Turner M.W., et al. Angiography and complement activation. Evidence for generation of C3a anaphylaxtoxin by intravascular contrast agents. Cardiovasc Res 19 (1985) 85-88
50. Ring J., Endrich B., and Intaglietta M. Histamine release, complement consumption, and microvascular changes after radiographic contrast media infusion in rabbits. J Lab Clin Med 92 (1978) 584-594
51. Ring J., Simon R.A., and Arroyave C.M. Increased in vitro histamine release by radiographic contrast media in patients with history of incompatibility. Clin Exp Immunol 34 (1978) 302-309
52. Brockow K., Vieluf D., Puschel K., et al. Increased postmortem serum mast cell tryptase in a fatal anaphylactoid reaction to nonionic radiocontrast medium. J Allergy Clin Immunol 104 (1999) 237-238
53. Dewachter P., Mouton-Faivre C., and Felden F. Allergy and contrast media. Allergy 56 (2001) 250-251
54. Yamaguchi K., Katayama H., Takashima T., et al. Prediction of severe adverse reactions to ionic and nonionic contrast media in Japan: evaluation of pretesting. A report from the Japanese committee on the safety of contrast media. Radiology 178 (1991) 363-367
55. Fischer H.W., and Doust V.L. An evaluation of pretesting in the problem of serious and fatal reactions to excretory urography. Radiology 103 (1972) 497-501
56. Wakkers-Garritsen B.G., Houwerziji J., Nater J.P., et al. IgE-mediated adverse reactivity to a radiographic contrast medium. Ann Allergy 36 (1976) 122-126
57. Kanny G., Maria Y., Mentre B., et al. Case report: recurrent anaphylactic shock to radiographic contrast media. Evidence supporting an exceptional IgE-mediated reaction. Allerg Immunol (Paris) 25 (1993) 425-430
58. Alvarez-Fernandez J.A., Valero A.M., Pulido Z., et al. Hypersensitivity reaction to ioversol. Allergy 55 (2000) 581-582
59. Laroche D., Dewachter P., Mouton-Faivre C., et al. Immediate reactions to iodinated contrast media: the CIRTACI study. [abstract]. Allergologie 27 (2004) 165
60. Blanca M., Torres M.J., Garcia J.J., et al. Natural evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics. J Allergy Clin Immunol 103 (1999) 918-924
61. Trcka J., Schmidt C., Seitz C.S., et al. Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy?. AJR Am J Roentgenol 190 (2008) 666-670
62. Mertes P.M., Laxenaire M.C., Lienhart A., et al. Reducing the risk of anaphylaxis during anaesthesia: guidelines for clinical practice. J Investig Allergol Clin Immunol 15 (2005) 91-101
63. Hari Y., Frutig-Schnyder K., Hurni M., et al. T cell involvement in cutaneous drug eruptions. Clin Exp Allergy 31 (2001) 1398-1408
64. Kanny G., Marie B., Hoen B., et al. Delayed adverse reaction to sodium ioxaglic acid-meglumine. Eur J Dermatol 11 (2001) 134-137
65. Watanabe H., Sueki H., Nakada T., et al. Multiple fixed drug eruption caused by iomeprol (Iomeron), a nonionic contrast medium. Dermatology 198 (1999) 291-294
66. Good A.E., Novak E., and Sonda III L.P. Fixed eruption and fever after urography. South Med J 73 (1980) 948-949
67. Courvoisier S., and Bircher A.J. Delayed-type hypersensitivity to a nonionic, radiopaque contrast medium. Allergy 53 (1998) 1221-1224
68. Kanzaki T., and Sakagami H. Late phase allergic reaction to a CT contrast medium (Iotrolan). J Dermatol 18 (1991) 528-531
69. Gall H., Pillekamp H., and Peter R.U. Late-type allergy to the x-ray contrast medium Solutrast (Iopamidol). Contact Derm 40 (1999) 248-250
70. Akiyama M., Nakada T., Sueki H., et al. Drug eruption caused by nonionic iodinated x-ray contrast media. Acad Radiol 1 Suppl 5 (1998) S159-S161
71. Beeler A., Zaccaria L., Kawabata T., et al. CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity. Allergy 63 (2008) 181-188
72. Pichler W.J. Immune mechanism of drug hypersensitivity. Immunol Allergy Clin North Am 24 (2004) 373-397
73. Pichler W.J. Delayed drug hypersensitivity reactions. Ann Intern Med 139 (2003) 683-693
74. Kwak R. [A case of shock by pretesting of contrast media]. Rinsho Hoshasen 30 (1985) 407-409 [in Japanese]
75. Gonzalo-Garijo M.A., de Argila D., Pimentel J.J., et al. Skin reaction to contrast medium. Allergy 52 (1997) 875-876
76. Morcos S.K., Thomsen H.S., and Webb J.A. Prevention of generalized reactions to contrast media: a consensus report and guidelines. Eur Radiol 11 (2001) 1720-1728
77. Dewachter P., and Mouton-Faivre C. [Severe reactions to iodinated contrast agents: is anaphylaxis responsible?]. J Radiol 82 (2001) 973-977 [in French]
78. Tramer M.R., von Elm E., Loubeyre P., et al. Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review. BMJ 333 (2006) 675-681
79. Kopp A.F., Mortele K.J., Cho Y.D., et al. Prevalence of acute reactions to iopromide: postmarketing surveillance study of 74,717 patients. Acta Radiol 49 (2008) 902-911
80. Greenberger P.A., and Patterson R. The prevention of immediate generalized reactions to radiocontrast media in high-risk patients. J Allergy Clin Immunol 87 (1991) 867-872
81. Ring J., Rothenberger K.H., and Clauss W. Prevention of anaphylactoid reactions after radiographic contrast media infusion by combined histamine H1- and H2-receptor antagonists: results of a prospective controlled trial. Int Arch Allergy Appl Immunol 78 (1985) 9-14
82. Freed K.S., Leder R.A., Alexander C., et al. Breakthrough adverse reactions to low-osmolar contrast media after steroid premedication. AJR Am J Roentgenol 176 (2001) 1389-1392
83. Roberts M., and Fisher M. Anaphylactoid reaction to iopamiro (after pretreatment). Australas Radiol 36 (1992) 144-146