Pleotropni ucinci polimorfzma ACE;Pleiotropic efects of ACE polymorphism

Biochemia Medica

Volumn 19, Issue 1, 2009, Pages 36-49

  Nawaz, Syed Kashif ^a   Hasnain, Shahida ^a  

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

ACE polymorphism; Ardiovascular diseases; Early mortality; Longevity

Indexed keywords

AMYLOID BETA PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE;

ALLERGIC RHINITIS; ALZHEIMER DISEASE; ASTHMA; ATHEROSCLEROSIS; BREAST CANCER; COLORECTAL CARCINOMA; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DNA POLYMORPHISM; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; KALLIKREIN KININ SYSTEM; LONGEVITY; MOUTH CANCER; MUSCLE FUNCTION; OSTEOPOROSIS; PARKINSON DISEASE; PLEIOTROPY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SEPSIS; STOMACH CANCER; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 67649196416     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (94)

1. Zhao Y, Xu C. Structure and function of angiotensin converting enzyme and its inhibitors. Chin J Biotech 2008; 24:171-6.
2. Turner AJ, Hooper NM. The angiotensin-converting enzyme gene family:genomics and pharmacology. Trends Pharmacol Sci 2002; 23:177-83.
3. Jaspard E, Wei L, Alhenc-Gelas F. Differences in the properties and enzyma ticspeciScitiesofthetwoactivesitesofangiotensinI-converting enzyme(kininaseII). Studies with bradykinin and other natural peptides. J Biol Chem 1993;268:9496-503.
4. Erdos EG, Skidgel RA. The angiotensin I-converting enzyme. Lab Invest 1987;56:345-8.
5. Brewster UC, Perazella MA There nin-angiotensin-aldosterone system and the kidney: effects on kidney disease. Am J Med 2004;116:263-72.
6. Carluccio M, Soccio M, De Caterina R. Aspects of gene polymorphisms in cardiovascular disease: the renin-angiotensin system. Eur J Clin Invest 2001;31:476-88.
7. Rajagopalan S, Kurz S, Munze lT, Tarpey M, Freeman BA, Griendling KK, HarrisonDG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 1996;97:1916-23.
8. Fleming I. Signaling by the angiotensin-converting enzyme. Circ Res 2006;14:98:887-96.
9. Hu J, Igarashi A, Kamata M, Nakagawa H. Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (Abeta); retards Abeta aggregation, deposition, fibril formation; and inhibits cytotoxicity. J Biol Chem 2001;276:47863-8.
10. Kondoh G, Tojo H, Nakatani Y, Komazawa N, Murata C, Yamagata K, et al. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 2005;11:160-6.
11. Hu bert C, Houot AM, Corvol P, Soubrier F. Structure of the angiotensin I-con verting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem 1991;266: 15377-83.
12. th intron of the somatic ACE gene. Mol Cell Biol 1990;10: 4294-302.
13. rd, Kumar RS, Sen GC. Use of alternative polyadenylationsites for tissue-specific transcription of two angiotensin-conver ting enzyme mRNAs. Nucleic Acids Res 1992;20:683-7.
14. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. Anin sertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-6.
15. Sayed-Tabatabaei FA, Oostra BA, Isaacs A, van Duijn CM, Witteman JCM. ACE polymorphisms. Circ Res 2006;98:1123-33.
16. Odawara M, Matsunuma A, Yam shita K. Mistyping frequency of the angiotensin converting enzymegenepolymor phism and animproved method for its avoidance. Hum Gen 1997;100:163-6.
17. Shanguman V, Sell KW, Saha BK. Mistyping ACE heterozygotes. genome Res 1993;3:120-1.
18. Chiang FT, Hsu KL, Chen WM, Tseng CD, Tseng YZ. Determination of angiotensin converting enzyme gene polymor phisms: step down PCR in creases detection of heterozygotes. Clin Chem 1998;44:1353-6.
19. Evans AE, Poirier O, Kee F, Lecerf L, McCrum E, Falconer T, et al. Polymorphisms of the angiotensin-converting-enzymegene in subjects who die from coronary heart disease. QJM 1994;87:211-4.
20. Lin MH, Tseng CH, Tseng CC, Huang CH, Chong CK, Tseng CP. Real time PCR for rapid genotyping of angiotensin converting enzyme in sertion/deletion polymorphism. Clin Biochem 2001;34:661-6.
21. Koyama RG, Castro RMRPS, De Mello MT, Tufik S, Pedrazzoli M. Simple detection of large InDeLS by DHPLC: the ACE geneasamo del. J Biomed Biotech 2008;568183.
22. Kajantie E, Rautanen A, Kere J, Andersson S, Yliharsila H, Osmond C, et al. The effects of the ACE geneinsertion/deletion polymorphism on glucose to lerance and insulin secretion in elderly people are modiffied by birth weight. J Clin Endocrinol Metab 2004;89:5738-41.
23. Barker DJP, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005;353:1802-9.
24. Rotteveel J, van Weissenbruch MM, Twisk JWR, de Waal HAD. In fant and childhood growth patterns, insulin sensitivity, and blood pressure in premature lyborn young adults. Pediatrics 2008;122:313-21.
25. Hindmarsh PC, Rodeck CH, Humphries SE. Polymor phisms in the angiotensin converting enzyme gene and growth in the first year of life. Ann Hum Gen 2007;71:176-84.
26. Feng Y, Niu T, Xu X, Chen C, Li Q, Qian R, et al. In sertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes. Diabetes 2002;51:1986-8.
27. Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, et al. The Dallele of the angiotensin-converting enzyme in sertion/deletion (I/D) polymorphism is a risk factor for type 2 diabetes in a population-based Japanese sample. Endocr J 2003;50:393-8.
28. Step hens JW, Dhamrait SS, Cooper JA, Acharya J, Miller GJ, Hurel SJ, Humphries SE. The Dallele of the ACE I/D commongenevariant is associated with type 2 diabetes mellitus in Caucasian subjects. Mol Genet Metab 2005;84:83-9.
29. Singh PP, Naz I, Gilmour A, Singh M, Mastana S. Association of APOE (Hha1) and ACE (I/D) gene polymorphisms with type 2 diabetes mellitus in North West India. Diabetes Res Clin Pract 2006;74:95-102.
30. Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY. Renin-angiotensin and endothelialnitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. J Intern Med 2007;263:376-85.
31. van-Valkengoed IGM, Stronks K, Hahntow IN, Hoekstra JBL, Holleman F. The angiotensin converting enzyme in sertion/deletion polymorphism and differences in fasting plasma glucose in Hindustani Surinamese, African Surinamese and ethnic Dutch: the population-based SUNSE T-study. Diabetes Res Clin Pract 2008;81:e12-e14.
32. Arfa I, Abid A, Nouira S, Ellou mi-Zghal H, Malouche D, Mannai I, et al. Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabeticnep hropathy in Tunisian type 2 diabetic patients. JRAAS 2008;9:32-6.
33. Eroglu Z, Cetinkalp S, Erdogan M, Kosova B, Karadeniz M, Kutukculer A, et al. Association of the angiotensinogen M235T and angiotensin converting enzyme in sertion/deletion gene polymorphisms in Turkish type 2 diabetic patients with and withoutnep hropathy. J Diabetes Complications 2008;22:186-90.
34. Ng DP, Tai BC, Koh D, Tan KW, Chia KS. Angiotensin-I converting enzyme in sertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects. Diabetologia 2005;48: 1008-16.
35. Movva S, Alluri RV, Komandur S, Vattam K, Eppa K, Mukkavali KK, et al. Relationship of angiotensin-converting enzyme gene polymorphism with nephropathy associated with type 2 diabetes mellitus in Asian Indians. J Diabetes Complications 2007;21:237-41.
36. Globocnik-Petrovic M, Hawlina M, Peterlin B, Petrovic D. insertion/deletion plasminogen activator in hibitor 1 and insertion/deletion angiotensin-converting enzyme gene polymorphismsin diabeticretino pathy in type 2 dia betes. Ophthal mologica 2003;217:219-24.
37. Matsumoto A, Iwashima Y, Abiko A, Morikawa A, Sekiguchi M, Eto M, Makino I. Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy. Diabetes Res Clin Pract 2000;50:195-202.
38. Feghhi M, Nikzamir A, Esteghamati A, Farahi F, Nakhja vani M, Rashidi A. The relationship between angiotensin-con verting enzyme in sertion/deletion polymorphism and proliferative retinopathy in type 2 diabetes. Diabetes Res Clin Pract 2008; 81:e1-e4.
39. Wiwanitkit V. Angiotensin-con verting enzyme gene polymorphism is correlated to diabetic retinopathy: a meta-analysis. J Diabetes Complications 2008;22:144-6.
40. Sayed-Taba tabaei FA, Houwing-Duistermaat JJ, van Duijn CM, Witteman JC. Angiotensin-converting enzyme gene polymorphism and carotidartery wall thickness: a meta-analysis. Stroke 2003;34:1634-9.
41. Pawel N, Iwona Z, Krystian W. The Dallele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of at herosclerosis. Clin Chem Lab Med 2008;46:446-52.
42. Kretowski A, McFann K, Hokanson JE, Maahs D, Kinney G, Snell-Bergeon JK, et al. Polymorphisms of the renin-angiotensin system genes predict progression of subclini calcoronary at heros clerosis. Diabetes 2007;56:863-71.
43. rd, Tracy RE, et al. ACE insert/delete polymorphism and atherosclerosis. Atherosclerosis 2005;178:241-7.
44. Oei HH, Sayed-Tabatabaei FA, Hofman A, Oudkerk M, van Duijn CM, Witteman JC. The association between angiotensin-converting enzyme gene polymorphism and coronary calcification. The Rotterdam Coronary Calcification Study. Atherosclerosis 2005;182:169-73.
45. Szadkowska A, Pietrzak I, Klich I, Mlynarski W, Bodal ska-Li pinska J, Bodalski J. Polymorphism I/D of the angiotensin-converting enzyme gene and disturbance of blood pressure in type 1 diabetic children and adolescents. Przegl Lek 2006;63:32-6.
46. Freitas SRS, Cabello PH, Moura-Neto RS, Dolinsky LC, Bóia MN. Combined Analysis of genetic and environmental factors on essential hypertension in a Brazilian rural population in the Amazon Region. Arq Bras Cardiol 2007;88:393-7.
47. Staessen JA, Wang JG, Ginocchio G, Petrov V, Saavedra AP, Soubrier F, et al. The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardio vascular-re nalrisk. J Hypertens 1997;15:1579-92.
48. Agerholm-Larsen B, Nordestgaard BG, Tybjaerg-Hansen A. ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler Thromb Vasc Biol 2000;20:484-92.
49. Miyama N, Hase gawa Y, Suzuki M, Hida W, Kazama I, Hatano R, et al. Investigation of major genetic polymorphisms in the renin-angiotensin- aldosterone system in subjects with young-onset hypertension selected by a targeted-screening system at university. Clin Exp Hypertens 2007;29:61-7.
50. Glavnik N, Petrovič D. M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians. Folia Biol (Praha) 2007;53:69-70.
51. Bautista LE, Vargas CI, Oróstegui M, Gamarra G. Population-based case-control study of renin-angiotensin system genes polymorphisms and hypertension among Hispanics. Hypertens Res 2008;31:401-8.
52. Zhang YL, Zhou SX, Lei J, Zhang JM. Association of angiotensin I-converting enzyme gene polymorphism with ACE and PAI-1 levels in Guangdong Chinese Hanpatients with essential hypertension. Nan Fang Yi Ke Da Xue Xue Bao 2007;27:1681-4.
53. Morshed M, Khan H, Akhteruzzaman S. Association between angiotensin I-converting enzyme gene polymorphism and hypertension in selected individuals of the Banglades hipopulation. J Bio chem Mol Biol 2002;35:251-4.
54. Higa ki J, Baba S, Katsuya T, Sato N, Ishikawa K, Mannami T, et al. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study. Circulation 2000;101:2060-5.
55. Jiménez PM, Conde C, Casanegra A, Romero C, Tabares AH, Orías M. Association of ACE geno type and predominantly diastolic hypertension: a preliminary Study. JRAAS 2007;8:42-4.
56. Nápoles OC, Castellanos MS, Leal L, Casalvilla R, Camacho H, Ferrer A, et al. ACE I/D polymorphism Study in a Cuban hypertensive population. Clin Chim Acta 2007;378:112-6.
57. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial in farction. Nature 1992;359:641-4.
58. Sharma P. Meta-analysis of the ACE gene in ischaemic stroke. J Neurol Neurosurg Psychiatry 1998;64:227-30.
59. Banerjee I, Gupta V, Ganesh S. Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis 2007. J Hum genet 2007;52:205-19.
60. Xu X, Li J, Sheng W, Liu L. meta-analysis of genetic studies from journals published in China of is chemic stroke in the Han Chinese population. Cerebrovasc Dis 2008;26:48-62.
61. Dikmen M, Günes HV, Degirmenci I, Ozdemir G, Basaran A. Arethe angiotensin-converting enzyme gene and activity risk factors for stroke? Arq Neuropsiquiatr 2006;64:211-6.
62. Kehoe PG, Russ C, McIlory S, Williams H, Holmans P, Holmes C, et al. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat genet 1999;21:71-2.
63. Kehoe PG, Katzov H, Feuk L, Bennet AM, Johansson B, Wiman B, et al. Haplo types extending across ACE are associated with Al zheimer's disease. Hum Mol genet 2003;12:859-67.
64. Lehmann DJ, Cortina-Borja M, Warden DR, Smith AD, Sleegers K, Prince JA, et al. Large meta-analysises tablishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. Am J Epide miol 2005;162:305-17.
65. Kölsch H, Jessen F, Freymann N, Kreis M, Hentschel F, Maier W, Heun R. ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia. Neurosci Lett 2005;377:37-9.
66. Sleegers K, den Heijer T, van Dijk EJ, Hofman A, Bertoli-Avella AM, Koudstaal PJ, et al. ACE gene is associated with Alzheimer's disease and at rophy of hippocampus and amygda le. Neuro biol Aging 2005;26:1153-9.
67. Nacmias B, Bagnoli S, Tedde A, Cellini E, Bessi V, Guarnieri B, et al. Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity. Arch Gerontol Geriatr 2007;45:201-6.
68. Camelo D, Arbole da G, Yunis JJ, Pardo R, Arango G, Solano E, et al. Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Co lombianpatients. J Neurol Sci 2004;218:47-51.
69. Bowirrat A, Cui J, Waraska K, Friedland RP, Oscar-Berman M, Farrer LA, et al. Lack of Association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel. Neuropsychiatr Dis Treat 2005;1:73-6.
70. Lin JJ, Yueh KC, Chang DC, Lin SZ. Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disease. J Neurol Sci 2003;199:25-9.
71. Lin JJ, Yueh KC, Lin SZ, Harn HJ, Liu JT. genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease. J Neurol Sci 2007;252:130-4.
72. Röcken C, Lendeckel U, Dierkes J, Westphal S, Carl-McGrath S, Peters B, et al. The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism. Clin cancer Res 2005;11:2526-30.
73. Koh WP, Yuan JM, Sun CL, van den Berg D, Seow A, Lee HP, Yu MC. Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore. Cancer Res 2003;63:573-8.
74. González-Zuloeta Ladd AM, Arias-Vásquez A, Sayed-Tabatabaei FA, Coebergh JW, Hofman A, Njajou O, et al. angiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer risk. Cancer Epide miol Biomar kers Prev 2005;14:2143-6.
75. Yaren A, Turgut S, Kursun luoglu R, Oztop I, Turgut G, Kelten C, Erdem E. Association between the polymorphism of the angiotensin-con verting enzyme gene and tumorsize of breast cancer in premenopausal patients. Tohoku J Exp Med 2006;210:109-16.
76. Van der Knaap R, Siemes C, Coebergh JW, van Duijn CM, Hofman A, Stricker BH. Renin-angiotensin system in hibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study. cancer 2008;112:748-57.
77. Vairaktaris E, Yapijakis C, Tsigris C, Vassiliou S, Derka S, Nkenke E, et al. Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with in crea sed risk for oral cancer. Acta Oncol 2007;46:1097-102.
78. Goto Y, Ando T, Nishio K, Ishida Y, Kawai S, Goto H, Hama jima N. The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gas tritis. Asian Pac J cancer Prev. 2005;6:464-7.
79. Röcken C, Neumann K, Carl-McGrath S, Lage H, Ebert MP, Dierkes J, et al. The gene polymorphism of the angiotensin I-converting enzyme correlates with tumorsize and patient survival in colorectal cancer patients. Neoplasia 2007;9:716-22.
80. Nikiteas N, Tsigris, C, Chatzitheofylaktou A, Yannopoulos A. Noassociation with risk for colorectal cancer of the insertion/deletion polymor phismwhich affects levels of angiotensin-converting enzyme. In Vivo 2007;21:1065-8.
81. Tanriverdi H, Evrengul H, Tanriverdi S, Turgut S, Akdag B, Kaftan HA, Semiz E. Improved endothelium dependent vasodilationin endurance athletes and its relation with ACE I/D polymorphism. Circ J 2005;69:1105-10.
82. Lucía A, Gómez-Gallego F, Chicharro JL, Hoyos J, Celaya K, Córdova A, et al. Is there an Association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? Int J Sports Med 2005;26:442-7.
83. Hruskovicová H, Dzurenková D, Selingerová M, Bohus B, Timkani cová B, Kovács L. The angiotensin converting enzyme I/D polymorphism in long distance runners. J Sports Med Phys Fitness 2006;46:509-13.
84. Moran CN, Vassilopoulos C, Tsiokanos A, Jamurtas AZ, Bailey ME, Montgomery HE, et al. The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents. Eur J Hum Genet 2006;14:332-9.
85. Cogulu O, Onay H, Uzunkaya D, Gunduz C, Pehlivan S, Vardar F, et al. Role of angiotensin-converting enzyme gene polymorphisms in children with sepsis and septic shock. Pediatr Int 2008;50:477-80.
86. Lue KH, Ku MS, Li C, Sun HL, Lee HS, Chou MC. ACE gene polymorphism might disclose why sometaiwanese children with allergic rhinitis develop asthma symptoms but others do not. Pediatr Allergy Immunol 2006;17:508-13.
87. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG. angiotensin-converting enzyme insertion/deletion polymorphism and systemic lupus erythematosus: a meta-analysis. J Rheumatol 2006;33:698-702.
88. Pérez-Castrillón JL, Justo I, Silva J, Sanz A, Martín-Escudero JC, Igea R, et al. relation ship between bone mine ralden sity and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women. Am J Hypertens 2003;16:233-5.
89. Lynn H, Kwok T, Wong SY, Woo J, Leung PC. angiotensin converting enzyme inhibitor use is associated with higher bone mineral density in elderly Chinese. Bone 2006;38:584-8.
90. Pérez-Castrillón JL, Silva J, Justo I, Sanz A, Martín-Luquero M, Igea R, et al. Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms. Am J Hypertens 2003;16:453-9.
91. Woods D, Onambele G, Woledge R, Skelton D, Bruce S, Humphries SE, Montgo mery H. Angiotensin-I converting enzyme geno type-dependent benefit from hormone replacement therapy in isometricmus clestrength and bone mineral density. J Clin Endocrinol metab 2001;86:2200-4.
92. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Le sueur-Ginot L, Cohen D. genetic associations with human longevity at the APOE and ACE loci. Nat genet 1994;6:29-32.
93. Blanche H, Cabanne L, Sahbatou M, Thomas G. A Study of French centenarians: are ACE and APOE associated with longevity? C R Acad Sci III 2001;324:129-35.
94. Arias-Vasquez A, Sayed-Taba tabaei FA, Schut AF, Hofman A, Bertolli-Avella AM, Vergeer JM, et al. angiotensin converting enzyme gene, smoking and mortality in a population-based Study. Eur J Clin Invest 2005;35:444-9.