Suggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch population

European Journal of Human Genetics

Volumn 17, Issue 7, 2009, Pages 958-966

  Amin, Najaf ^a   Aulchenko, Yuri S ^a   Dekker, Marieke C ^a,b   Ferdinand, Robert F ^c   van Spreeken, Alwin ^d   Temmink, Alfons H ^e   Verhulst, Frank C ^f   Oostra, Ben A ^a   van Duijn, Cornelia M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c De Waag Center for Forensic Psychiatry   (Netherlands)

^d SINT FRANCISCUS GASTHUIS   (Netherlands)

^e AMPHIA HOSPITAL   (Netherlands)

^f SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CHROMOSOME 18Q; CHROMOSOME 6; CLINICAL ARTICLE; FEMALE; GENE ISOLATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; LEUKOCYTE; MALE; MICROSATELLITE MARKER; NETHERLANDS; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHROMOSOMES, HUMAN, PAIR 18; DNA; FEMALE; GENETIC LINKAGE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LOD SCORE; MALE; MICROSATELLITE REPEATS; NETHERLANDS; PEDIGREE; RECEPTORS, SEROTONIN;

EID: 67649188876     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2008.260     Document Type: Article

References (52)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th edn, American Psychiatric Publishing: Washington, DC, 1994.
2. Wolraich ML, Hannah JN, Pinnock TY, Baumgaertel A, Brown J: Comparison of diagnostic criteria for attention-deficit hyperactivity disorder in a county-wide sample. J Am Acad Child Adolesc Psychiatry 1996; 35 319-324.
3. Swanson JM, Sergeant JA, Taylor E, Sonuga-Barke EJ, Jensen PS, Cantwell DP: Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet 1998; 351: 429-433.
4. Cantwell DP: AttentionAdeficit disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 1996; 35: 978-987.
5. Thapar A, Hervas A, McGuffin P: Childhood hyperactivity scores are highly heritable and show sibling competition effects: Twin study evidence. Behav Genet 1995; 25: 537-544.
6. Edelbrock C, Rende R, Plomin R, Thompson LA: A twin study of competence and problem behavior in childhood and early adolescence. J Child Psychol Psychiatry 1995; 36: 775-785.
7. Faraone SV, Doyle AE: The nature and heritability of attention-deficit/ hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 2001; 10: 299-316, viii-ix.
8. Gjone H, Stevenson J, Sundet JM: Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample. J Am Acad Child Adolesc Psychiatry 1996; 35: 588-596; discussion 596-588.
9. Levy F, Hay DA, McStephen M, Wood C, Waldman I: Attention-deficit hyperactivity disorder: A category or a continuum? Genetic analysis of a large-scale twin study. J Am Acad Child Adolesc Psychiatry 1997; 36: 737-744.
10. Sherman DK, Iacono WG, McGue MK: Attention-deficit hyperactivity disorder dimensions: A twin study of inattention and impulsivity-hyperactivity. J Am Acad Child Adolesc Psychiatry 1997; 36: 745-753.
11. Smalley SL: Genetic influences in childhood-onset psychiatric disorders: autism and attention-deficit/hyperactivity disorder. Am J Hum Genet 1997; 60: 1276-1282.
12. Faraone SV, Biederman J, Monuteaux MC: Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genet Epidemiol 2000; 18: 1-16.
13. Thapar A, O'Donovan M, Owen MJ: The genetics of attention deficit hyperactivity disorder. Hum Mol Genet 2005; 14 (Spec no. 2 : R275-R282.
14. Faraone SV, Doyle AE, Mick E, Biederman J: Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 2001; 158: 1052-1057.
15. Maher BS, Marazita ML, Ferrell RE, Vanyukov MM: Dopamine system genes and attention deficit hyperactivity disorder: A meta-analysis. Psychiatr Genet 2002; 12: 207-215.
16. Fisher SE, Francks C, McCracken JT et al: A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 2002; 70: 1183-1196.
17. Bakker SC, van der Meulen EM, Buitelaar JK et al: A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: Suggestive evidence for linkage on chromosomes 7p and 15q. Am J Hum Genet 2003; 72: 1251-1260.
18. Hebebrand J, Dempfle A, Saar K et al: A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs. Mol Psychiatry 2006; 11: 196-205.
19. Asherson P, Zhou K, Anney RJ et al: A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Mol Psychiatry 2008; 13: 514-521.
20. Faraone SV, Doyle AE, Lasky-Su J et al: Linkage analysis of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1387-1391.
21. Rommelse NN, Arias-Vasquez A, Altink ME et al: Neuropsychological endophenotype approach to genome-wide linkage analysis identifies susceptibility loci for ADHD on 2q21.1 and 13q12.11. Am J Hum Genet 2008; 83: 99-105.
22. Zhou K, Asherson P, Sham P et al: Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biol Psychiatry 2008; 64: 571-576.
23. Ogdie MN, Fisher SE, Yang M et al: Attention deficit hyperactivity disorder: Fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11. Am J Hum Genet 2004; 75: 661-668.
24. Ogdie MN, Macphie IL, Minassian SL et al: A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11. Am J Hum Genet 2003; 72: 1268-1279.
25. Arcos-Burgos M, Castellanos FX, Pineda D et al: Attention-deficit/ hyperactivity disorder in a population isolate: Linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. Am J Hum Genet 2004; 75: 998-1014.
26. Romanos M, Freitag C, Jacob C et al: Genome-wide linkage analysis of ADHD using high-density SNP arrays: Novel loci at 5q13.1 and 14q12. Mol Psychiatry 2008; 13: 522-530.
27. Neale BM, Lasky-Su J, Anney R et al: Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1337-1344.
28. Aulchenko YS, Vaessen N, Heutink P et al: A genome-wide search for genes involved in type 2 diabetes in a recently genetically isolated population from the Netherlands. Diabetes 2003; 52: 3001-3004.
29. Vaessen N, Heutink P, Houwing-Duistermaat JJ et al: A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands. Diabetes 2002; 51: 856-859.
30. Pardo LM, MacKay I, Oostra B, van Duijn CM, Aulchenko YS: The effect of genetic drift in a young genetically isolated population. Ann Hum Genet 2005; 69: 288-295.
31. Aulchenko YS, Heutink P, Mackay I et al: Linkage disequilibrium in young genetically isolated Dutch population. Eur J Hum Genet 2004; 12: 527-534.
32. Heutink P, Oostra BA: Gene finding in genetically isolated populations. Hum Mol Genet 2002; 11: 2507-2515.
33. Croes EA, El Galta R, Houwing-Duistermaat JJ et al: Phenotypic subtypes in attention deficit hyperactivity disorder in an isolated population. Eur J Epidemiol 2005; 20: 789-794.
34. Ferdinand RF, van der Ende J: NIMH DISC-IV: Diagnostic Interview Schedule for Children. Authorized Dutch Translation. Rotterdam, the Netherlands: Erasmus MC-Sophia, 2000.
35. Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME: NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 2000; 39 28-38.
36. de Nijs PF, Ferdinand RF, de Bruin EI, Dekker MC, van Duijn CM, Verhulst DC: Attention-deficit/hyperactivity disordeP (ADHD): parents' judgment about school, teachers' judgment about home. Eur Child Adolesc Psychiatry 2004; 13: 315-320.
37. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
38. Liu F, Kirichenko A, Axenovich TI, Duijn CMV, Aulchenko YS: An approach for cutting large and complex pedigrees for linkage analysis. Eur J Hum Genet 2008; 16: 854-860.
39. Aulchenko YS, Bertoli-Avella AM, van Duijn CM: A method for pooling alleles from different genotyping experiments. Ann Hum Genet 2005; 69: 233-238.
40. Mukhopadhyay N, Almasy L, Schroeder M, Mulvihill WP, Weeks DE: Mega2, a data-handling program for facilitating genetic linkage and association analyses. Am J Hum Genet 1999; 65: A436.
41. Lander ES, BotstAin D: Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science 1987; 236: 1567-1570.
42. Liu F, Elefante S, van Duijn CM, Aulchenko YS: Ignoring distant genealogic loops leads to false-positives in homozygosity mapping. Ann Hum Genet 2006; 70: 965-970.
43. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
44. Freimer NB, Reus VI, Escamilla MA et al: Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet 1996; 12: 436-441.
45. Schumacher J, Anthoni H, Dahdouh F et al: Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet 2006; 78: 52-62.
46. Fisher SE, Marlow AJ, Lamb J et al: A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. Am J Hum Genet 1999; 64: 146-156.
47. Gayan J, Smith SD, Cherny SS et al: Quantitative-trait locus for specific language and reading deficits on chromosome 6p. Am J Hum Genet 1999; 64: 157-164.
48. Grigorenko EL, Wood FB, Meyer MS, Pauls DL: Chromosome 6p influences on different dyslexia-related cognitive processes: Further confirmation. Am J Hum Genet 2000; 66: 715-723.
49. Willcutt EG, Pennington BF, Smith SD et al: Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. Am J Med Genet 2002; 114: 260-268.
50. Brunner D, Buhot MC, Hen R, Hofer M: Anxiety, motor activation, and maternal-infant interactions in 5HT1B knockout mice. Behav Neurosci 1999; 113: 587-601.
51. Hawi Z, DringM, Kirley A et al: Serotonergic system and attention deficit hyperactivity disorder (ADHD): A potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Mol Psychiatry 2002; 7: 718-725.
52. Quist JF, Barr CL, Schachar R et al: The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Mol Psychiatry 2003; 8: 98-102.