Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution

Respiratory Medicine

Volumn 103, Issue 8, 2009, Pages 1167-1173

  de Vries, Tjalling W ^a   Rottier, Bart L ^b   Gjaltema, Doetie ^c   Hagedoorn, Paul ^c   Frijlink, Henderik W ^c   de Boer, Anne H ^c  

^a MEDICAL CENTER LEEUWARDEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Delivered dose; Inhaled corticosteroid; Laser diffraction; Particle size distribution; Pressurized metered dose inhaler

Indexed keywords

BECLOMETASONE; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CICLESONIDE; FLUTICASONE; FLUTICASONE PROPIONATE;

ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; METERED DOSE INHALER; PARTICLE SIZE; PEAK INSPIRATORY FLOW; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ANDROSTADIENES; ASTHMA; BECLOMETHASONE; BUDESONIDE; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; MATERIALS TESTING; METERED DOSE INHALERS; PARTICLE SIZE; PREGNENEDIONES;

EID: 67649121826     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2009.02.010     Document Type: Article

References (22)

1. GINA. Pocket Guide for asthma management and prevention in children. Available at URL (2006). http://www.ginasthma.org
2. British Thoracic Society, and Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax 63 Suppl. 4 (2008) 1-121
3. Esposito-Festen J.E., Zanen P., Tiddens H.A.W.M., and Lammers J.W.J. Pharmacokinetics of inhaled monodisperse beclomethasone as a function of particle size. Br J Clin Pharmacol 64 (2007) 328-334
4. Lindstroem M. Particles in small airways: mechanisms for deposition and clearance. Thesis, Stockholm: Karolinska Institute; 2004.
5. Schuepp K.G., Jauernig J., Janssens H.M., Tiddens H.A.W.M., Straub D.A., Stangl D., et al. In vitro determination of the optimal particle size for nebulised aerosol delivery to infants. J Aerosol Med 18 (2005) 225-235
6. Gabrio B.J., Stein S.W., and Velasquez D.J. A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int J Pharm 186 (1999) 3-12
7. Leach C.L. Improved delivery of inhaled steroids to the large and small airways. Respir Med 92 (1998) 3-8
8. Seale J.P., and Harrison L.I. Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics. Respir Med 92 (1998) 9-15
9. Colice G.L. The newly developed inhaled corticosteroid ciclesonide for the treatment of asthma. Expert Opin Pharmacother 7 (2006) 2107-2117
10. Leach C.L., Davidson P.J., and Boudreau R.J. Improved airway targeting with CFC-free HFA-beclomethasone metered-dose inhaler compared with FCF-beclomethasone. Eur Respir J 12 (1998) 1346-1353
11. Asmus M.J., Liang J., Coowanitwong I., Vafadari R., and Hochhaus G. In vitro deposition of fluticasone aerosol from a metered-dose inhaler with and without two common valved holding chambers. Ann Allergy Asthma Immunol 88 (2002) 204-208
12. Asmus M.J., Coowanitwong I., Kwon S.H., Khorsand N., and Hochhaus G. In vitro performance of two common valved holding chambers with a chlorofluorocarbon-free beclomethasone metered-dose inhaler. Pharmacotherapy 23 (2003) 1538-1544
13. Asmus M.J., Liang J., Coowanitwong I., and Hochhaus G. In vitro performance characteristics of valved holding chamber and spacer devices with a fluticasone metered-dose inhaler. Pharmacotherapy 24 (2004) 159-166
14. Louca E., Leung K., Coates A.L., Mitchell J.P., and Nagel M.W. Comparison of three valved holding chambers for the delivery of fluticasone propionate-HFA to an infant face model. J Aerosol Med 19 (2006) 160-167
15. Kamin W., and Ehlich H. In vitro comparison of output and particle size distribution of budesonide from metered-dose inhaler with three spacer devices during pediatric tidal breathing. Treat Respir Med 5 (2006) 503-508
16. Terzano C., and Mannino F. Aerosol characterization of three corticosteroid metered dose inhalers with volumatic holding chambers and metered dose inhalers alone at two inspiratory flow rates. J. Aerosol Med 12 (1999) 249-254
17. Feddah M.R., Brown K.F., Gipps E.M., and Davies N.M. In-Vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates. J Pharm Pharm Sci 3 (2000) 317-324
18. Dalby R.N., Somaraju S., Chavan V.S., and Jarvis D. Evaluation of aerosol drug output from the OptiChamber and AeroChamber spacers in a model system. J Asthma 35 (1998) 173-177
19. Barry P.W., and O'Callaghan C. A comparative analysis of the particle size output of beclomethasone dipropionate, salmeterol xinafoate and fluticasone dipropionate metered dose inhalers used with the Babyhaler, Volumatic and Aerochamber spacer. Br J Clin Pharmacol 47 (1999) 357-360
20. Stein S.W. Size distribution measurements of metered dose inhalers using Andersen Mark II cascade impactors. Int J Pharm 186 (1999) 43-52
21. Gerrity T.R. Pathophysiological and disease constraints on aerosol delivery. In: Byron P.R. (Ed). Respiratory drug delivery (1990), CRC Press Inc., Boca Raton, USA 1-38
22. Roller C.M., Zhang G.I., Troedson R.G., Leach C.L., LeSoeuef P.N., and Devadason S.G. Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. Eur Respir J 29 (2007) 299-306