Cost effectiveness analysis of larval therapy for leg ulcers

BMJ (Online)

Volumn 338, Issue 7702, 2009, Pages 1050-1053

  Soares, Marta O ^c   Iglesias, Cynthia P ^c   Bland, J Martin ^a   Cullum, Nicky ^a   Dumville, Jo C ^c   Nelson, E Andrea ^b   Torgerson, David J ^a   Worthy, Gill ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL TRIAL; COMPRESSION THERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; COST UTILITY ANALYSIS; DEBRIDEMENT; HEALTH CARE COST; HUMAN; HYDROGEL DRESSING; LEG ULCER; MAGGOT THERAPY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SKIN NECROSIS; TREATMENT DURATION; TREATMENT OUTCOME; WOUND HEALING;

AGED; ANIMALS; BANDAGES; COST-BENEFIT ANALYSIS; DEBRIDEMENT; DIPTERA; FEMALE; HEALTH CARE COSTS; HUMANS; HYDROGEL; KAPLAN-MEIER ESTIMATE; LARVA; LEG ULCER; LENGTH OF STAY; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; NECROSIS; PAIN; QUALITY-ADJUSTED LIFE YEARS; STAPHYLOCOCCAL INFECTIONS; TIME FACTORS; TREATMENT OUTCOME; WOUND HEALING;

EID: 67649118072     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.b825     Document Type: Article

References (27)

1. Nelzen O, Bergqvist D, Lindhagen A. Venous and non-venous leg ulcers: clinical history and appearance in a population study. Br J Surg 1994;81:182-187 (Pubitemid 24122342)
2. Callam MJ, Ruckley CV, Harper DR, Dale JJ. Chronic ulceration of the leg: extent of the problem and provision of care. BMJ 1985;290:1855-1856 (Pubitemid 15062841)
3. Cullum N, Nelson EA, Flemming K, Sheldon T. Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy. Health Technol Assess 2001;5:1-221.
4. Cullum N, Nelson EA, Fletcher AW, Sheldon TA. Compression for venous leg ulcers.[update of Cochrane Database Syst Rev 2000;(3):CD000265]. Cochrane Database Syst Rev 2001(2):CD000265.
5. Iglesias C, Nelson EA, Cullum NA, Torgerson DJ, Ven UST. VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers. Health Technol Assess 2004;8(29):iii. (Pubitemid 39172654)
6. Bradley M, Cullum N, Sheldon T. The debridement of chronic wounds: a systematic review. Health Technol Assess 3(17 Pt 1):iii-iv. (Pubitemid 29427241)
7. Royal College of Nursing. The nursing management of venous leg ulcers. London: Royal College of Nursing, 2006.
8. Scottish Intercollegiate Guidelines Network. The care of patients with chronic leg ulcers. Edinburgh: SIGN Secretariat, 1998.
9. Wayman J, Nirojogi V, Walker A, Sowinski A, Walker MA. The cost effectiveness of larval therapy in venous ulcers. J Tissue Viability 2000;10:91-94
10. Dumville J, Worthy G, Soares M, Bland JM, Cullum N, Dowson C, et al. Larval therapy for leg ulcers (VenUS II): randomised controlled trial, BMJ 2009;338:b773.
11. National Institute for Health and Clinical Excellence. NICE technical guidance for manufacturers and sponsors on making a submission to a technology appraisal. London: NICE, 2001.
12. British Medical Association, Royal Pharmaceutical Society of Great Britain. British national formulary. London: BMA, RPS, 2006:825-838 (No 52.)
13. Curtis L Netten A. Unit costs of health and social care. Canterbury, University of Kent: Personal Social Services Research Unit, 2006.
14. Drummond M, Sculpher M, Torrance G, O'Brien B, Stoddart G. Methods for the economic evaluation of health care programmes. 3rd edn. Oxford: Oxford University Press, 2005.
15. Kind PT. The EuroQol instrument: an index of health-related quality of life. In: Spilker B, ed. Quality of life and pharmacoeconomics in clinical trials. Philadelphia: Lippincott-Raven, 1996.
16. Dolan P, Gudex C, Kind P, Williams A. A social tariff for EuroQol: results froma UK general population survey. Discussion paper series (No 138). York: Centre for Health Economics, 1995.
17. Manca A, Hawkins N, Sculpher MJ. Estimating mean QALYs in trial-based cost-effectiveness analysis: the importance of controlling for baseline utility. Health Econ 2005;14:487-496 (Pubitemid 40723857)
18. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ 1990;300:230-235 (Pubitemid 20045528)
19. Zhao H, Tsiatis AA. A consistent estimator for the distribution of quality adjusted survival time. Biometrika 1997;84:339-348
20. Lin DY. Linear regression analysis of censored medical costs. Biostatistics 2000;1:35-47. (Pubitemid 33213520)
21. Willan AR, Lin DY, Manca A. Regression methods for cost-effectiveness analysis with censored data. Stat Med 2005;24:131-145 (Pubitemid 40074070)
22. Willan AR, Lin DY, Cook RJ, Chen EB. Using inverse-weighting in cost-effectiveness analysis with censored data. Stat Methods Med Res 2002;11:539-551 (Pubitemid 36104144)
23. Efron B, Tibshirani R, J. An introduction to the bootstrap. London: Chapman and Hall, 1993.
24. Fenwick E, O'Brien BJ, Briggs A. Cost-effectiveness acceptability curves - facts, fallacies and frequently asked questions. Health Econ 2004;13:405-415 (Pubitemid 38660390)
25. Dumville J, Worthy G, Soares M, Bland JM, Cullum N, Dowson C, et al. VenUS II: A randomised controlled trial of larval therapy in the management of leg ulcers. Health Technol Assess (in press).
26. Iglesias CP, Birks Y, Nelson EA, Scanlon E, Cullum NA. Quality of life of people with venous leg ulcers: a comparison of the discriminative and responsive characteristics of two generic and a disease specific instruments. Qual Life Res 2005;14:1705-1718 (Pubitemid 40978479)
27. Gardiner JC, Luo Z, Bradley CJ, Sirbu CM, Given CW. A dynamic model for estimating changes in health status and costs. Stat Med 2006;25:3648-3667 (Pubitemid 44613900)