Increased red cell corpuscular volume and hepatic mitochondrial function in NRTI-treated HIV infected patients

Current HIV Research

Volumn 7, Issue 3, 2009, Pages 336-339

  Sternfeld, Thomas ^a,c   Lorenz, Antje ^b   Schmid, Mathias ^c   Schlamp, Angelika ^c   Demmelmair, Hans ^c   Koletzko, Berthold ^c   Bogner, Johannes R ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Klinikum Deggendorf   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Antiretroviral therapy; Breath test; HIV; MCV; Methionine; Mitochondrial

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; CARBON 13; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; HEMOGLOBIN; INDINAVIR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; METHIONINE; NELFINAVIR; NEVIRAPINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBON;

ADULT; BASELINE CARBON DIOXIDE ENRICHMENT; BREATH ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIVER FUNCTION TEST; LIVER MITOCHONDRION; MALE; MAXIMAL BASELINE CARBON DIOXIDE ENRICHMENT VALUE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MEGALOCYTOSIS; MITOCHONDRIAL TOXICITY; REVIEW; SIDE EFFECT; TIME TO REACH MAXIMAL BASELINE CARBON DIOXIDE ENRICHMENT VALUE; ARTICLE; CELL SIZE; DRUG EFFECT; ERYTHROCYTE; METABOLISM; MIDDLE AGED; MITOCHONDRION;

ADULT; ANTI-HIV AGENTS; BREATH TESTS; CARBON ISOTOPES; CELL SIZE; ERYTHROCYTES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; REVERSE TRANSCRIPTASE INHIBITORS; YOUNG ADULT;

EID: 67649109002     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016209788347985     Document Type: Review

References (17)

1. Cherry CL, Lala L, Wesselingh SL. Mitochondrial toxicity of nucleoside analogues: mechanism, monitoring and management. Sex Health 2005; 2(1):1-11.
2. Spahr L, Negro F, Leandro G, et al. Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis. Med Sci Monit 2003; 9(1): CR6-11.
3. Candelli M, Armuzzi A, Nista EC, Fini L, Gasbarrini G, Gasbarrini A. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther 2004; 19(2): 243.
4. Candelli M, Cazzato IA, Zocco MA, et al. 13C-breath tests in the study of mitochondrial liver function. Eur Rev Med Pharmacol Sci 2004; 8(1): 23-31.
5. Miele L, Grieco A, Armuzzi A, et al. Hepatic mitochondrial betaoxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test. Am J Gastroenterol 2003; 98(10): 2335-6.
6. Di Campli C, Angelini G, Armuzzi A, et al. Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. Eur J Gastroenterol Hepatol 2003; 15(7): 727-32.
7. Armuzzi A, Candelli M, Zocco MA, et al. Review article: breath testing for human liver function assessment. Aliment Pharmacol Ther 2002; 16(12): 1977-96.
8. Eyer-Silva WA, Arabe J, Pinto JF, Morais-De-Sa CA. Macrocytosis in patients on stavudine. Scand J Infect Dis 2001; 33(3): 239-40.
9. Romanelli F, Empey K, Pomeroy C. Macrocytosis as an indicator of medication (zidovudine) adherence in patients with HIV infection. AIDS Patient Care STDS 2002; 16(9): 405-11.
10. Steele RH, Keogh GL, Quin J, Fernando SL, Stojkova V. Mean cell volume (MCV) changes in HIV-positive patients taking nucleoside reverse transcriptase inhibitors (NRTIs): a surrogate marker for adherence. Int J STD AIDS 2002; 13(11): 748-54.
11. Khawcharoenporn T, Shikuma CM, Williams AE, Chow DC. Lamivudine-associated macrocytosis in HIV-infected patients. Int J STD AIDS 2007; 18(1): 39-40.
12. Walker UA, Brinkman K. NRTI induced mitochondrial toxicity as a mechanism for HAART related lipodystrophy: fact or fiction? HIV Med 2001; 2(3): 163-5.
13. Armuzzi A, Marcoccia S, Zocco MA, et al. Non-Invasive assessment of human hepatic mitochondrial function through the 13Cmethionine breath test. Scand J Gastroenterol 2000; 35(6): 650-3.
14. Kharbanda KK. Role of transmethylation reactions in alcoholic liver disease. World J Gastroenterol 2007; 13(37): 4947-54.
15. MacDougall BR, Dordoni B, Thompson RP, Davis M, Williams R. [1-14C]Ethanol breath test in alcoholic liver disease. Clin Chim Acta 1978; 86(1): 121-7.
16. Koivisto H, Hietala J, Anttila P, Parkkila S, Niemela O. Long-term ethanol consumption and macrocytosis: diagnostic and pathogenic implications. J Lab Clin Med 2006; 147(4): 191-6.
17. Geene D, Sudre P, Anwar D, Goehring C, Saaidia A, Hirschel B. Causes of macrocytosis in HIV-infected patients not treated with zidovudine. Swiss HIV Cohort Study. J Infect 2000; 40(2): 160-3.