Insulinoma-lnduced hypoglycemia in a patient with nesidiodysplasia after vagomotomy and pyloroplasty for duodenal ulcer

American Journal of the Medical Sciences

Volumn 337, Issue 5, 2009, Pages 377-380

  Iglesias, Pedro ^a,c   Ais, Guillermo ^a   Pastrana, Maximo ^a   Etreros, Javier ^a   Salinas, Silvia ^b   Diez, Juan J ^c  

^a Departments of Endocrinology   (Spain)

^b HOSPITAL GENERAL DE SEGOVIA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Hypoglycemia; Insulinoma; Nesidiodysplasia; Pyloroplasty; Vagotomy

Indexed keywords

DIAZOXIDE; C PEPTIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; ASPIRATION BIOPSY; CANCER SURGERY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIARRHEA; DIZZINESS; DUODENUM ULCER; DYSPLASIA; ENDOSCOPIC ECHOGRAPHY; FEMALE; HEART PALPITATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERHIDROSIS; HYPERINSULINISM; HYPOGLYCEMIA; INSULINOMA; LABORATORY TEST; NAUSEA; NESIDIODYSPLASIA; ORAL GLUCOSE TOLERANCE TEST; PANCREAS RESECTION; POSTGASTRECTOMY SYNDROME; PYLOROPLASTY; SENSOR; SWEATING; TACHYCARDIA; TREMOR; VAGOTOMY; WEAKNESS; WEIGHT GAIN; GLUCOSE TOLERANCE TEST; METABOLISM; MIDDLE AGED; PANCREAS DISEASE; PANCREAS ISLET; PANCREAS TUMOR; PATHOLOGY; TIME;

C-PEPTIDE; DUODENAL ULCER; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIA; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MIDDLE AGED; PANCREATIC DISEASES; PANCREATIC NEOPLASMS; TIME FACTORS; VAGOTOMY;

EID: 67649083773     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3181907b06     Document Type: Article

References (18)

1. Service FJ. Classification of hypoglycemic disorders. Endocrinol Metab Clin North Am 1999;28:501-17.
2. Laid lawaidlaw GF. Nesidioblastoma, the cell islet tumor of the pancreas. Am J Pathol 1938;14:125-34.
3. Goudswaard WB, Houthoff HJ, Koudstaal J, et al. Nesidioblastosis and endocrine hyperplasia of the pancreas: a secondary phenomenon. Hum Pathol 1986;17:46-54.
4. Glaser B, Phillip M, Carmi R, et al. Persistent hyperinsulinemic hypoglycemia of infancy ("nesidioblastosis"): autosomal recessive inheritance in 7 pedigrees. Am J Med Gen 1990;37:511-5.
5. Won JG, Tseng HS, Yang AH, et al. Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS). Clin Endocrinol (Oxf) 2006; 65:566-78.
6. Service FJ, Natt N, Thompson GB, et al. Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes. J Clin Endocrinol Metab 1999;84:1582-9.
7. Thompson GB, Service FJ, Andrews JC, et al. Noninsulinoma pancreatogenous hypoglycemia syndrome: an update in 10 surgically treated patients. Surgery 2000;128:937-44.
8. Service GJ, Thompson GB, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med 2005;353:249-54.
9. Gould VE, Memoli VA, Dardi LE, et al. Nesidiodysplasia and nesidioblastosis of infancy: structural and functional correlations with the syndrome of hyperinsulinemic hypoglycemia. Pediatr Pathol 1983; 1:7-31.
10. Zumkeller W. Nesidioblastosis. Endocr Relat Cancer 1999;6:421-8.
11. Rosman J, Bravo-Vera R, Sheikh A, et al. Metastatic insulinoma in an adult patient with underlying nesidioblastosis. J Endocrinol Invest 2007;30:521-4.
12. Kaczirek K, Soleiman A, Schindl M, et al. Nesidioblastosis in adults: a challenging cause of organic hyperinsulinism. Eur J Clin Invest 2003;33:488-92.
13. Patti ME, McMahon G, Mun EC, et al. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabeto-logia 2005;48:2236-40.
14. Zagury L, Moreira RO, Guedes EP, et al. Insulinoma misdiagnosed as dumping syndrome after bariatric surgery. Obes Surg 2004; 14: 120-3.
15. Kloppel G, Anlauf M, Raffel A, et al. Adult diffuse nesidioblastosis: genetically or environmentally induced? Hum Pathol 2008;39:3-8.
16. Wiznitzer T, Shapira N, Stadler J, et al. Late hypoglycemia in patients following vagotomy and pyloroplasty. Int Surg 1974;59: 229-32.
17. Hall WH, Snaders LL. Hypoglycemic convulsions after vagotomy and pyloroplasty. South Med J 1973;66:502-4.
18. Radziuk J, Bondy DC. Abnormal oral glucose tolerance and glucose malabsorption after vagotomy and pyloroplasty. A tracer method for measuring glucose absorption rates. Gastroenterology 1982;83:1017-25.