Narcolepsy - Master of disguise: Evidence-based recommendations for management

Postgraduate Medicine

Volumn 121, Issue 3, 2009, Pages 99-104

  Mohsenin, Vahid ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Cataplexy; Hypersomnia; Narcolepsy; REM sleep; Sleepiness

Indexed keywords

DEXAMPHETAMINE; ESCITALOPRAM; FLUOXETINE; IMIPRAMINE; METHYLPHENIDATE; MODAFINIL; OXYBATE SODIUM; VENLAFAXINE; BENZHYDRYL DERIVATIVE; CENTRAL DEPRESSANT AGENT; CENTRAL STIMULANT AGENT;

ADULT; ANTICHOLINERGIC SYNDROME; CARDIOVASCULAR DISEASE; CASE MANAGEMENT; CASE REPORT; CATAPLEXY; CLINICAL ASSESSMENT; DAYTIME SOMNOLENCE; DEPRESSION; DIZZINESS; DROWSINESS; HEADACHE; HEART ARRHYTHMIA; HEART PALPITATION; HUMAN; HYPERSOMNIA; LIFESTYLE MODIFICATION; MALE; NARCOLEPSY; NAUSEA; NERVOUSNESS; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; PRACTICE GUIDELINE; REM SLEEP; RESPIRATION DEPRESSION; RESTLESSNESS; REVIEW; SIDE EFFECT; ARTICLE; ATTENTION DEFICIT DISORDER; CATALEPSY; DIFFERENTIAL DIAGNOSIS; DRUG COMBINATION; DRUG EFFECT; EVIDENCE BASED MEDICINE; FOLLOW UP; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY;

ADJUVANTS, ANESTHESIA; ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS; BENZHYDRYL COMPOUNDS; CATALEPSY; CENTRAL NERVOUS SYSTEM STIMULANTS; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY, COMBINATION; EVIDENCE-BASED MEDICINE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NARCOLEPSY; POLYSOMNOGRAPHY; SLEEP, REM; SODIUM OXYBATE;

EID: 67549150911     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.3810/pgm.2009.05.2008     Document Type: Review

References (30)

1. Bassetti C, Aldrich MS. Narcolepsy. Neurol Clin. 1996;14(3):545-571.
2. Aldrich MS. Narcolepsy. N Engl J Med. 1990;323(6):389-394.
3. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437(7063):1257-1263. (Pubitemid 41568665)
4. Billiard M, Pasquié-Magnetto V, Beckman M, et al. Family studies in narcolepsy. Sleep. 1994;17(8 suppl):S54-S59.
5. Mignot E. Genetic and familial aspects of narcolepsy. Neurology. 1998;50(2 suppl 1):S16-S22. (Pubitemid 28100862)
6. Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98(4):437-451. (Pubitemid 29402482)
7. Lin L, Faraco J, Li R, Kadotani H, et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999;98(3):365-376. (Pubitemid 29380571)
8. Siegel JM, Boehmer LN. Narcolepsy and the hypocretin system - where motion meets emotion. Nat Clin Pract Neurol. 2006;2(10):548-556. (Pubitemid 44458076)
9. Heier MS, Evsiukova T, Vilming S, Gjerstad MD, Schrader H, Gautvik K. CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in Norway. Sleep. 2007;30(8):969-973. (Pubitemid 47221896)
10. Hublin C, Partinen M, Kaprio I, Koskenvuo M, Guilleminault C. Epidemiology of narcolepsy. Sleep. 1994;17(8 suppl):S7-S12.
11. Ohayon MM, Priest RG, Zulley J, Smirne S, Paiva T. Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology. 2002;58(12):1826-1833. (Pubitemid 34663586)
12. Longstreth WT Jr, Koepsell TD, Ton TG, Hendrickson AF, van Belle G. The epidemiology of narcolepsy. Sleep. 2007;30(1):13-26. (Pubitemid 46098865)
13. Singh M, Drake CL, Roth T. The prevalence of multiple sleep-onset REM periods in a population-based sample. Sleep. 2006;29(7):890-895.
14. Punjabi NM, Welch D, Strohl K. Sleep disorders in regional sleep centers: a national cooperative study. Coleman II Study Investigators. Sleep. 2000;23(4):471-480.
15. Colten HR, Altevogt BM, eds. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problems. Washington, DC: The National Academies Press; 2005.
16. Kryger MH, Walid R, Manfreda J. Diagnoses received by narcolepsy patients in the year prior to diagnosis by a sleep specialist. Sleep. 2002;25(1):36-41. (Pubitemid 34072657)
17. Littner MR, Kushida C, Wise M, Davila DG, et al. Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep. 2005;28(1):113-121.
18. Vignatelli L, D'Alessandro R, Candelise L. Antidepressant drugs for narcolepsy. Cochrane Database Syst Rev. 2008(1):CD003724. (Pubitemid 351807491)
19. Mitler MM, Aldrich MS, Koob GF, Zarcone VP. Narcolepsy and its treatment with stimulants. ASDA standards of practice. Sleep. 1994;17(4):352-371.
20. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. US Modafinil in Narcolepsy Multicenter Study Group. Ann Neurol. 1998;43(1):88-97.
21. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group. Neurology. 2000;54(5):1166-1175.
22. Harsh JR, Hayduk R, Rosenberg R, et al. The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy. Curr Med Res Opin. 2006;22(4):761-774.
23. Morgenthaler TI, Kapur VK, Brown T, et al; Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007;30(12):1705-1711.
24. Poryazova R, Siccoli M, Werth E, Bassetti CL. Unusually prolonged rebound cataplexy after withdrawal of fluoxetine. Neurology. 2005;65(6):967-968. (Pubitemid 41362161)
25. Langdon N, Shindler J, Parkes JD, Bandak S. Fluoxetine in the treatment of cataplexy. Sleep. 1986;9(2):371-373. (Pubitemid 18020428)
26. Frey J, Darbonne C. Fluoxetine suppresses human cataplexy: a pilot study. Neurology. 1994;44(4):707-709. (Pubitemid 24130003)
27. A randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy. Sleep. 2002;25(1):42-49. (Pubitemid 34072658)
28. Weaver TE, Cuellar N. A randomized trial evaluating the effectiveness of sodium oxybate therapy on quality of life in narcolepsy. Sleep. 2006;29(9):1189-1194. (Pubitemid 44484812)
29. Littner M, Johnson SF, McCall WV, et al; Standards of Practice Committee. Practice parameters for the treatment of narcolepsy: an update for 2000. Sleep. 2001;24(4):451-466.
30. Johns MW. Sleepiness in different situations measured by the Epworth Sleepiness Scale. Sleep. 1994;17(8):703-710.