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Volumn 14, Issue 1, 2009, Pages 23-31

The effect of CYP3A5 and ABCBl single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients

Author keywords

ABCB1; CYP3A5; Liver transplant; Single nucleotide polymorphisms; Tacrolimus

Indexed keywords

CYTOCHROME P450 3A5; MULTIDRUG RESISTANCE PROTEIN 1; TACROLIMUS; ABCB1 PROTEIN, HUMAN; CYP3A5 PROTEIN, HUMAN; CYTOCHROME P450 3A; GLYCOPROTEIN P; IMMUNOSUPPRESSIVE AGENT;

EID: 67549139183     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (49)

References (62)
  • 2
    • 0029330155 scopus 로고
    • Intra-and interindividual variation in the pharmacokinetics of tacrolimus (FK506) in kidney transplant recipients-importance of trough level as a practical indicator
    • Ihara H, Shinkuma D, Ichikawa Y et al: Intra-and interindividual variation in the pharmacokinetics of tacrolimus (FK506) in kidney transplant recipients-importance of trough level as a practical indicator. Int J Urol, 1995; 2:151-55
    • (1995) Int J Urol , vol.2 , pp. 151-55
    • Ihara, H.1    Shinkuma, D.2    Ichikawa, Y.3
  • 3
    • 0028792553 scopus 로고
    • Analysis of tacrolimus (FK506) in relation to therapeutic drug monitoring
    • Jusko WJ: Analysis of tacrolimus (FK506) in relation to therapeutic drug monitoring. Ther Drug Monit, 1995; 17: 596-601
    • (1995) Ther Drug Monit , vol.17 , pp. 596-601
    • Jusko, W.J.1
  • 4
    • 0029560982 scopus 로고
    • Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions, and interindividual variability
    • Lampen A, Christians U, Guengerich FP et al: Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos, 1995; 23: 1315-24
    • (1995) Drug Metab Dispos , vol.23 , pp. 1315-24
    • Lampen, A.1    Christians, U.2    Guengerich, F.P.3
  • 5
    • 0037319247 scopus 로고    scopus 로고
    • Toward better outcomes with tacrolimus therapy: Population pharmacokinetics and individualized dosage prediction in adult liver transplantation
    • Staatz CE, Willis C, Taylor PJ et al: Toward better outcomes with tacrolimus therapy: Population pharmacokinetics and individualized dosage prediction in adult liver transplantation. Liver Transp, 2003; 9:130-37
    • (2003) Liver Transp , vol.9 , pp. 130-37
    • Staatz, C.E.1    Willis, C.2    Taylor, P.J.3
  • 6
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis. Comparisons of inter-and intra-individual variations can substitute for twin studies in drug research
    • Kalow W, Tang BK, Endrenyi L: Hypothesis. Comparisons of inter-and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics, 1998; 8: 283-89
    • (1998) Pharmacogenetics , vol.8 , pp. 283-89
    • Kalow, W.1    Tang, B.K.2    Endrenyi, L.3
  • 7
    • 0026662551 scopus 로고
    • Cytochrome P-450 3A enzymes are responsible for biotransfor-mation of FK506 and rapamycin in man and rat
    • Sattler M, Guengerich FP, Yun CH et al: Cytochrome P-450 3A enzymes are responsible for biotransfor-mation of FK506 and rapamycin in man and rat. Drug Metab Dispos, 1992; 20: 753-61
    • (1992) Drug Metab Dispos , vol.20 , pp. 753-61
    • Sattler, M.1    Guengerich, F.P.2    Yun, C.H.3
  • 8
    • 0031748173 scopus 로고    scopus 로고
    • Wilkinson GR In vitro and in vivo drug interactions involving human CYP3A
    • Thummel KE, Wilkinson GR In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol, 1998; 38: 389-430
    • (1998) Annu Rev Pharmacol Toxicol , vol.38 , pp. 389-430
    • Thummel, K.E.1
  • 9
    • 0026496950 scopus 로고
    • The role of individual human cytochrome P450 in drug metabolism and clinical response
    • Cholerton S, Daly AK, Idle JR The role of individual human cytochrome P450 in drug metabolism and clinical response. Trends Pharmacol Sci, 1992; 13: 434-39
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 434-39
    • Cholerton, S.1    Daly, A.K.2    Idle, J.R.3
  • 10
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y et al: Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet, 2001; 27: 383-91
    • (2001) Nat Genet , vol.27 , pp. 383-91
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 11
    • 3242779991 scopus 로고    scopus 로고
    • CYP3A5*l-car-rying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation
    • Goto M, Masuda S, Kiuchi T et al: CYP3A5*l-car-rying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation. Pharmacogenetics, 2004; 14: 471-78
    • (2004) Pharmacogenetics , vol.14 , pp. 471-78
    • Goto, M.1    Masuda, S.2    Kiuchi, T.3
  • 12
    • 0037115210 scopus 로고    scopus 로고
    • Tacrolimus pharmacogenetics. Polymorphisms associated with expression of cytochrome P4503A5 and P-glycoprotein correlate with dose requirement
    • Macphee I, Fredericks S, Tai T et al: Tacrolimus pharmacogenetics. Polymorphisms associated with expression of cytochrome P4503A5 and P-glycoprotein correlate with dose requirement. Transplantation, 2002; 74:1486-89
    • (2002) Transplantation , vol.74 , pp. 1486-89
    • Macphee, I.1    Fredericks, S.2    Tai, T.3
  • 13
    • 9144245517 scopus 로고    scopus 로고
    • Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism
    • Zheng H, Zeevi A, Schuetz E et al: Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism. J Clin Pharmacol, 2004; 44: 135-40
    • (2004) J Clin Pharmacol , vol.44 , pp. 135-40
    • Zheng, H.1    Zeevi, A.2    Schuetz, E.3
  • 14
    • 7044272257 scopus 로고    scopus 로고
    • Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients
    • Tsuchiya N, Satoh S, Tada H et al: Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients. Transplantation, 2004; 78:1182-87
    • (2004) Transplantation , vol.78 , pp. 1182-87
    • Tsuchiya, N.1    Satoh, S.2    Tada, H.3
  • 15
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK506
    • Saeki T, Ueda K, Tanigawara Y et al: Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem, 1993; 268: 6077-80
    • (1993) J Biol Chem , vol.268 , pp. 6077-80
    • Saeki, T.1    Ueda, K.2    Tanigawara, Y.3
  • 16
    • 0023447098 scopus 로고
    • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissue
    • Thiebaut F, Tsuruo T, Hamada H et al: Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissue. Proc Natl Acad Sci USA, 1987; 84: 7735-38
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7735-38
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 17
    • 0032949332 scopus 로고    scopus 로고
    • Molecular and physical mechanisms of first-pass extraction
    • Hall SD, Thumel KE, Watkins PB et al: Molecular and physical mechanisms of first-pass extraction. Drug Metabol Dispos, 1999; 27:161-66
    • (1999) Drug Metabol Dispos , vol.27 , pp. 161-66
    • Hall, S.D.1    Thumel, K.E.2    Watkins, P.B.3
  • 18
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption. Combined role of cytochrome P450 3Aand P-glycoprotein
    • Zhang Y, Benet LZ: The gut as a barrier to drug absorption. Combined role of cytochrome P450 3Aand P-glycoprotein. Clin Pharmacokinet, 2001; 40:159-68
    • (2001) Clin Pharmacokinet , vol.40 , pp. 159-68
    • Zhang, Y.1    Benet, L.Z.2
  • 19
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S, Burk O, von Richter O et al: Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA, 2000; 97: 3473-78
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3473-78
    • Hoffmeyer, S.1    Burk, O.2    von Richter, O.3
  • 20
    • 0036881077 scopus 로고    scopus 로고
    • The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol
    • Siegmund W, Ludwig K, Giessmann T et al: The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. Clin Pharmacol Ther, 2002; 72: 572-83
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 572-83
    • Siegmund, W.1    Ludwig, K.2    Giessmann, T.3
  • 21
    • 0038304548 scopus 로고    scopus 로고
    • Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
    • Anglicheau D, Verstuyft C, Laurent-Puig P et al: Association of the multidrug resistance-1 gene sin-gle-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients. J Am Soc Nephrol, 2003; 14:1889-96
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1889-96
    • Anglicheau, D.1    Verstuyft, C.2    Laurent-Puig, P.3
  • 22
    • 25144433260 scopus 로고    scopus 로고
    • Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    • Wang D, Johnson AD, Papp AC et al: Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics, 2005; 15: 693-704
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 693-704
    • Wang, D.1    Johnson, A.D.2    Papp, A.C.3
  • 23
    • 33748710224 scopus 로고    scopus 로고
    • Multi-drug resistance gene-1 (MDR-1) haplotypes have a minor influence on tacrolimus dose requirements
    • Fredericks S, Moreton M, Reboux S et al: Multi-drug resistance gene-1 (MDR-1) haplotypes have a minor influence on tacrolimus dose requirements. Transplantation 2006; 82: 705-8
    • (2006) Transplantation , vol.82 , pp. 705-8
    • Fredericks, S.1    Moreton, M.2    Reboux, S.3
  • 24
    • 33750952260 scopus 로고    scopus 로고
    • Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms
    • Li D, Gui R, Huanz Z, Nie X: Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms. Transplant Proc, 2006; 38: 2580-82
    • (2006) Transplant Proc , vol.38 , pp. 2580-82
    • Li, D.1    Gui, R.2    Huanz, Z.3    Nie, X.4
  • 25
    • 0034744113 scopus 로고    scopus 로고
    • No influence of the MDR-1 C3435T polymorphisms or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporine A trough concentration or rejection incidence in stable renal transplant recipients
    • von Ahsen N, Richter M, Grupp C et al: No influence of the MDR-1 C3435T polymorphisms or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporine A trough concentration or rejection incidence in stable renal transplant recipients. Clin Chem, 2001; 47: 1048-52
    • (2001) Clin Chem , vol.47 , pp. 1048-52
    • von Ahsen, N.1    Richter, M.2    Grupp, C.3
  • 26
    • 0036001238 scopus 로고    scopus 로고
    • C3435T mutation in exon 26 of the human MDR-1 gene and cyclosporine pharmacokinetics in healthy subjects
    • Min DI, Ellingrod VL: C3435T mutation in exon 26 of the human MDR-1 gene and cyclosporine pharmacokinetics in healthy subjects. Ther Drug Monit, 2002; 24: 400-4
    • (2002) Ther Drug Monit , vol.24 , pp. 400-4
    • Min, D.I.1    Ellingrod, V.L.2
  • 27
    • 34447515970 scopus 로고    scopus 로고
    • Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population
    • Jeannesson E, Albertini L, Siest G et al: Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population. Fundam Clin Pharmacol, 2007; 21: 411-18
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 411-18
    • Jeannesson, E.1    Albertini, L.2    Siest, G.3
  • 28
    • 0035104031 scopus 로고    scopus 로고
    • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    • Cascorbi I, GerioffT, Johne A et al: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharm Ther, 2001; 69: 169-74
    • (2001) Clin Pharm Ther , vol.69 , pp. 169-74
    • Cascorbi, I.1    Geriofft, J.A.2
  • 29
    • 33845232219 scopus 로고    scopus 로고
    • Effects of genetic polymorphisms on the pharmacokinetics of cal-cineurin inhibitors
    • Utecht KN, Hiles JJ, Kolesar J: Effects of genetic polymorphisms on the pharmacokinetics of cal-cineurin inhibitors. Am J Health Syst Pharm, 2006; 63: 2340-48
    • (2006) Am J Health Syst Pharm , vol.63 , pp. 2340-48
    • Utecht, K.N.1    Hiles, J.J.2    Kolesar, J.3
  • 30
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther, 1994; 270: 414-23
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-23
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 31
    • 0025009831 scopus 로고
    • Wang RK et al: Effects of age and gender on in vitro propertiesof human liver microsomal monoxygenases
    • Schmucker DL, Woodhouse KW, Wang RK et al: Effects of age and gender on in vitro propertiesof human liver microsomal monoxygenases. ClinPharmacol Ther, 1990: 48; 365-74
    • (1990) ClinPharmacol Ther , vol.48 , pp. 365-74
    • Schmucker, D.L.1    Woodhouse, K.W.2
  • 32
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J, Byth K, Farrell GC: Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol, 1995; 50: 727-30
    • (1995) Biochem Pharmacol , vol.50 , pp. 727-30
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 33
    • 33746764453 scopus 로고    scopus 로고
    • Factors affecting the apparent clearance of tacrolimus in Korean adult liver transplant recipients
    • Lee JY, Hahn HJ, Son IJ et al: Factors affecting the apparent clearance of tacrolimus in Korean adult liver transplant recipients. Pharmacotherapy, 2006; 26:1069-77
    • (2006) Pharmacotherapy , vol.26 , pp. 1069-77
    • Lee, J.Y.1    Hahn, H.J.2    Son, I.J.3
  • 34
    • 11944274532 scopus 로고    scopus 로고
    • The influence of age and sex on the clearance of cytochrome P4503A substrates
    • Cotreau MM, Von Moltke LL and Greenblatt DJ. The influence of age and sex on the clearance of cytochrome P4503A substrates. Clin Pharmacokinet, 2005; 44: 33-60
    • (2005) Clin Pharmacokinet , vol.44 , pp. 33-60
    • Cotreau, M.M.1    von Moltke, L.L.2    Greenblatt, D.J.3
  • 35
    • 27644467774 scopus 로고    scopus 로고
    • Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids
    • Mourad M, Mourad G, Wallemacq P et al: Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids. Transplantation, 2005; 80:977-84
    • (2005) Transplantation , vol.80 , pp. 977-84
    • Mourad, M.1    Mourad, G.2    Wallemacq, P.3
  • 36
    • 0242351679 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between corticoster-oids and tacrolimus after renal transplantation
    • Anglicheau D, Flamant M, Schlageter MH et al: Pharmacokinetic interaction between corticoster-oids and tacrolimus after renal transplantation. Nephrol Dial Transplant, 2003; 18: 2409-14
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 2409-14
    • Anglicheau, D.1    Flamant, M.2    Schlageter, M.H.3
  • 37
    • 0036851317 scopus 로고    scopus 로고
    • Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy
    • Shimada T, Terada A, Yokogawa K et al: Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. Transplantation, 2002; 74: 1419-24
    • (2002) Transplantation , vol.74 , pp. 1419-24
    • Shimada, T.1    Terada, A.2    Yokogawa, K.3
  • 38
  • 40
    • 0035217180 scopus 로고    scopus 로고
    • The genetic determinants of the CYP3A5 polymorphism
    • Hustert E, Haberl M, Burk O et al: The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics, 2001; 11: 773-79
    • (2001) Pharmacogenetics , vol.11 , pp. 773-79
    • Hustert, E.1    Haberl, M.2    Burk, O.3
  • 41
    • 10344264967 scopus 로고    scopus 로고
    • Pharmacokinetics of immunosuppressants: A perspective on ethnic differences
    • Dirks NL, Huth B, Yates CR, Meibohm B: Pharmacokinetics of immunosuppressants: a perspective on ethnic differences. IntJ Clin Pharmacol Ther, 2004; 42: 701-18
    • (2004) IntJ Clin Pharmacol Ther , vol.42 , pp. 701-18
    • Dirks, N.L.1    Huth, B.2    Yates, C.R.3    Meibohm, B.4
  • 42
    • 0037159922 scopus 로고    scopus 로고
    • Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HlV-nega-tive and HIV-positive Caucasians
    • Ifergan I, Bernard NF, Bruneau J et al: Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HlV-nega-tive and HIV-positive Caucasians. AIDS, 2002; 16: 2340-42
    • (2002) AIDS , vol.16 , pp. 2340-42
    • Ifergan, I.1    Bernard, N.F.2    Bruneau, J.3
  • 44
    • 3042772026 scopus 로고    scopus 로고
    • Identification of functionally variant MDR1 alleles among Europeans Americans and African Americans
    • Kim RB, Leake BF, Choo EF, et al. Identification of functionally variant MDR1 alleles among Europeans Americans and African Americans. Clin Pharmacol Ther, 2001; 70:189-99
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 189-99
    • Kim, R.B.1    Leake, B.F.2    Choo, E.F.3
  • 45
    • 0035051412 scopus 로고    scopus 로고
    • MDR1 pharmacogenetics: Frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    • Ameyaw MM, Regateiro F, Li T et al: MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics, 2001; 11: 217-21.
    • (2001) Pharmacogenetics , vol.11 , pp. 217-21
    • Ameyaw, M.M.1    Regateiro, F.2    Li, T.3
  • 46
    • 31144450792 scopus 로고    scopus 로고
    • Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing adult lung transplant patients who are CYP3A5*3/*3 non-expressors
    • Wang J, Zeevi A, McCurry K et al: Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing adult lung transplant patients who are CYP3A5*3/*3 non-expressors. Transplant Immunology, 2006; 15: 235-40
    • (2006) Transplant Immunology , vol.15 , pp. 235-40
    • Wang, J.1    Zeevi, A.2    McCurry, K.3
  • 47
    • 33645864935 scopus 로고    scopus 로고
    • Effects of CYP3A5 polymorphism on tacrolius metabolic clearance in vitro
    • Dai Y, Hebert MF, Isoherranen N et al: Effects of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro. Drug Metab Dispos, 2007; 34: 836-47
    • (2007) Drug Metab Dispos , vol.34 , pp. 836-47
    • Dai, Y.1    Hebert, M.F.2    Isoherranen, N.3
  • 48
    • 34548640104 scopus 로고    scopus 로고
    • ZhuJY et al: Population pharmacoki-netics of tacrolimus and CYP3A5, MDR-1 and IL-10 polymorphisms in adult liver transplant patients
    • Li D, Lu W, ZhuJY et al: Population pharmacoki-netics of tacrolimus and CYP3A5, MDR-1 and IL-10 polymorphisms in adult liver transplant patients. J Clin Pharm Ther, 2007; 32: 505-15
    • (2007) J Clin Pharm Ther , vol.32 , pp. 505-15
    • Li, D.1    Lu, W.2    Zhu, J.Y.3
  • 49
    • 0242332169 scopus 로고    scopus 로고
    • Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to dose ratio in renal transplant recipients
    • Thervet E, Anglicheau D, King B et al: Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to dose ratio in renal transplant recipients. Transplantation, 2003; 76: 1233-35
    • (2003) Transplantation , vol.76 , pp. 1233-35
    • Thervet, E.1    Anglicheau, D.2    King, B.3
  • 50
    • 0037693831 scopus 로고    scopus 로고
    • Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms
    • Zheng H, Webber S, Zeevi A et al: Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms. Am J Transplant, 2003; 3: 477-83
    • (2003) Am J Transplant , vol.3 , pp. 477-83
    • Zheng, H.1    Webber, S.2    Zeevi, A.3
  • 51
    • 2942588886 scopus 로고    scopus 로고
    • The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation
    • MacPhee LA, Fredericks S, Tai T et al: The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation. Am J Transplant, 2004; 4: 914-19
    • (2004) Am J Transplant , vol.4 , pp. 914-19
    • Macphee, L.A.1    Fredericks, S.2    Tai, T.3
  • 52
    • 31044454408 scopus 로고    scopus 로고
    • JinJ et al: Influence of CYP3A5 gene polymorphisms of donor rather than recipient to tacrolimus individual dose requirement in liver transplantation
    • Yu S, Wu L, JinJ et al: Influence of CYP3A5 gene polymorphisms of donor rather than recipient to tacrolimus individual dose requirement in liver transplantation. Transplantation, 2006; 81: 46-51
    • (2006) Transplantation , vol.81 , pp. 46-51
    • Yu, S.1    Wu, L.2    Jin, J.3
  • 53
    • 31344466713 scopus 로고    scopus 로고
    • Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients
    • Uesugi M, Masuda S, Katsura T et al: Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients. Pharmacogenet Genomics, 2006; 16:119-27
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 119-27
    • Uesugi, M.1    Masuda, S.2    Katsura, T.3
  • 54
    • 0038106665 scopus 로고    scopus 로고
    • Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodinamics of drugs
    • Sakaeda T, Nakamura T, Okumura K: Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodinamics of drugs. Pharmacogenomics, 2003; 4: 397-410
    • (2003) Pharmacogenomics , vol.4 , pp. 397-410
    • Sakaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 55
    • 12144286933 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
    • Haufroid V, Mourad M, Van Kerckhove V et al: The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics, 2004; 14:147-54
    • (2004) Pharmacogenetics , vol.14 , pp. 147-54
    • Haufroid, V.1    Mourad, M.2    van Kerckhove, V.3
  • 57
    • 9144253194 scopus 로고    scopus 로고
    • MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients
    • Mai I, Perloff ES, Bauer S et al: MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients. Br J Clin Pharmacol, 2004; 58: 548-53
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 548-53
    • Mai, I.1    Perloff, E.S.2    Bauer, S.3
  • 58
    • 34447549311 scopus 로고    scopus 로고
    • Tacrolimus pharmacokinetics and pharmacogenetics: Influence of adenosine triphosphate-bind-ing cassette Bl (ABCB1) and cytochrome (CYP) 3A polymorphisms
    • Op den Buijsch RA, Christiaans MH, Stolk LM et al: Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-bind-ing cassette Bl (ABCB1) and cytochrome (CYP) 3A polymorphisms. Fundam Clin Pharmacol, 2007; 21: 427-35
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 427-35
    • Op den Buijsch, R.A.1    Christiaans, M.H.2    Stolk, L.M.3
  • 59
    • 20344375240 scopus 로고    scopus 로고
    • Impact of CYP3A5 and MDR1 (ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients
    • Tada H, Tsuchiya N, Satoh H: Impact of CYP3A5 and MDR1 (ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients. Transplant Proc, 2005; 37: 1730-32
    • (2005) Transplant Proc , vol.37 , pp. 1730-32
    • Tada, H.1    Tsuchiya, N.2    Satoh, H.3
  • 60
    • 23244459511 scopus 로고    scopus 로고
    • Population pharmacokinetic estimation of tacrolimus apparent clearance in adult liver transplant recipients
    • Zahir H, McLachlan AJ, Nelson A et al: Population pharmacokinetic estimation of tacrolimus apparent clearance in adult liver transplant recipients. Ther Drug Monit, 2005; 27: 422-30
    • (2005) Ther Drug Monit , vol.27 , pp. 422-30
    • Zahir, H.1    McLachlan, A.J.2    Nelson, A.3
  • 61
    • 33745487508 scopus 로고    scopus 로고
    • Active drug transport of immunosuppressants: New insights for pharmacokinetics and pharmacodinamics
    • Christians U, Strom T, Zhang YL et al: Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodinamics. Ther Drug Monit, 2006; 28: 39-44
    • (2006) Ther Drug Monit , vol.28 , pp. 39-44
    • Christians, U.1    Strom, T.2    Zhang, Y.L.3
  • 62
    • 33745484478 scopus 로고    scopus 로고
    • Pharmacogenetics in transplant patients. Can it predict pharmacokinetics and pharmacodynamics
    • Burckart GJ and Liu XI. Pharmacogenetics in transplant patients. Can it predict pharmacokinetics and pharmacodynamics? Ther Drug Monit, 2006; 28: 23-30
    • (2006) Ther Drug Monit , vol.28 , pp. 23-30
    • Burckart, G.J.1    Liu, X.I.2


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