Investigations on the physical structure and the mechanism of drug release from an enteric matrix microspheres with a near-zero-order release kinetics using SEM and quantitative FTIR

AAPS PharmSciTech

Volumn 10, Issue 2, 2009, Pages 615-623

  Obeidat, Wasfy M ^a,d   Obeidat, Safwan M ^b   Alzoubi, Nizar M ^c  

^a UNIVERSITY OF SHARJAH   (United Arab Emirates)

^b PHILADELPHIA UNIVERSITY   (Jordan)

^c APPLIED SCIENCE PRIVATE UNIVERSITY   (Jordan)

^d JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

Author keywords

Enteric; FTIR; Microspheres; Narrow size; SEM

Indexed keywords

EUDRAGIT; MICROSPHERE; THEOPHYLLINE; ACRYLIC ACID RESIN; EUDRAGIT RS; METHYLMETHACRYLATE METHACRYLIC ACID COPOLYMER; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; INFRARED SPECTROSCOPY; MICROPHOTOGRAPHY; PH; QUANTITATIVE STUDY; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION; CHEMISTRY; KINETICS; SOLUBILITY; VISCOSITY;

ACRYLIC RESINS; HYDROGEN-ION CONCENTRATION; KINETICS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYMETHACRYLIC ACIDS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THEOPHYLLINE; VISCOSITY;

EID: 67549137765     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9240-3     Document Type: Article

References (22)

1. Stithit S, Chen W, Price JC. Development and characterization of buoyant theophylline microspheres with near zero order release kinetics. J Microencapsul 1998;15:725-37.
2. Obeidat WM, Price JC. Viscosity of polymer solution phase and other factors controlling the dissolution of theophylline microspheres prepared by the emulsion solvent evaporation method. J Microencapsul 2003;20:57-65.
3. Obeidat WM, Price JC. Preparation and evaluation of Eudragit S100 microspheres as pH sensitive release preparations for piroxicam and theophylline using the emulsion-solvent evaporation method. J Microencapsul 2006;23:195-202.
4. Obeidat WM, Obaidat IM. Effect of the dispersion of Eudragit S100 powder on the properties of cellulose acetate butyrate microspheres containing theophylline made by the emulsion-solvent evaporation method. J Microencapsul 2007;24:263-73.
5. Li SP, Kowalski CR, Feld KM, Grim WM. Recent advances in microencapsulation technology and equipment. Drug Dev Ind Pharm 1988;14:353-76.
6. Conti B, Giunchedi P, Conte U. Cellulose microparticles in drug delivery. STP Pharm Sci 1997;7:331-42.
7. Hosny EA, El-Mahrouk GM, Gouda MW. Formulation and in vitro and in vivo availability of diclofenac sodium enteric coated beads. Drug Dev Ind Pharm 1998;24:7661-6.
8. O'Donnell PB, McGinity JW. Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliv Rev 1997;28:25-42.
9. Pekarek KJ, Jacob JS, Mathiowitz E. Double-walled polymer microspheres for controlled drug release. Nature 1994;367:258-60.
10. Sayed HAM, Price JC. Tablet properties and dissolution characteristics of compressed cellulose acetate butyrate microcapsules containing succinyl sulfathiazole. Drug Dev Ind Pharm 1986;12:577-87.
11. Shukla AJ, Price JC. Effect of drug loading and molecular weight of cellulose acetate propionate on the release characteristics of theophylline microspheres. Pharm Res 1991;8:1396-400.
12. Obeidat WM, Price JC. Preparation and in vitro evaluation of propylthiouracil microspheres made of Eudragit RL 100 and cellulose acetate butyrate polymers using the emulsion-solvent evaporation method. J Microencapsul 2005;22:281-9.
13. Squillante E, Morshed G, Bagchi S, Mehta KA. Microencapsulation of β-galactosidase with Eudragit L 100. J Microencapsul 2003;20:153-67.
14. Rodriguez M, Vila-Jato JL, Torres D. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J Control Release 1998;55:67-77.
15. Peppas NA, Wood KM, Blanchette JO. Hydrogels for oral delivery for oral delivery of therapeutic proteins. Expert Opinion Biological Therapy 2004;4:881-7.
16. Bodmeier R, Chen H. Preparation and characterization of microspheres containing the anti inflammatory agents, indomethacin, ibuprofen and ketoprofen. J Control Release 1989;10:167-75.
17. Röhm Pharma GmbH. Eudragit®: Technical literature. Darmstadt: Röhm Pharma GmbH; 2005.
18. Kimberley AL, Sanna T, Paul JS, James EP. Solubility and permeability determination of anhydrous theophylline with application to the biopharmaceutics classification system. Midland: The Dow Chemical Company Literature; 2002.
19. Ritger PL, Peppas NA. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J Control Release 1987;5:37-42.
20. Saks SR, Gardner LB. The pharmacoeconomic value of controlled-release dosage forms. J Control Release 1997;48:237-42.
21. Brereton RG. Chemometrics: Data analysis for the laboratory and chemical plant. Hoboken: Wiley; 2005.
22. Obeidat S, Rayson G, Bai B, Anderson D. A multi-source portable LED spectrofluorometer. Appl Spectrosc 2008;62:327-32.