Formulation design and optimization of novel taste masked mouth-dissolving tablets of tramadol having adequate mechanical strength

AAPS PharmSciTech

Volumn 10, Issue 2, 2009, Pages 574-581

  Madgulkar, Ashwini R ^a   Bhalekar, Mangesh R ^a   Padalkar, Rahul R ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

Mechanical strength; Mouth dissolving tablets; Optimization; Taste masking; Tramadol

Indexed keywords

TRAMADOL; NARCOTIC ANALGESIC AGENT;

ADULT; ARTICLE; BITTER TASTE; BODY TEMPERATURE; DRUG DESIGN; DRUG EFFICACY; DRUG SOLUBILITY; HUMAN; MASKING; MATHEMATICAL MODEL; NORMAL HUMAN; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; SWALLOWING; TABLET DISINTEGRATION; TABLET FORMULATION; VALIDATION PROCESS; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; INFRARED SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PH; SOLUBILITY; STATISTICAL MODEL; TABLET; TASTE; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANALGESICS, OPIOID; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; HYDROGEN-ION CONCENTRATION; MODELS, STATISTICAL; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TASTE; TRAMADOL; X-RAY DIFFRACTION;

EID: 67549134677     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9237-y     Document Type: Article

References (24)

1. Grond S, Sablotzi A. Clinical pharmacology of tramadol. Clin Pharmacokinet 2004;43(13):879-923.
2. Bagul U et al. Manufacturing technologies for mouth dissolving tablets. www.pharmainfo.net, 2006; May 31.
3. Biradar S, Bhagavati S and Kuppasad. Fast dissolving drug delivery system: A brief overview. Internet J Pharmacol. 2006;4(2).
4. Chang R, Guo X, Burnside B, Couch R. Fast-dissolving tablets. Pharm Technol 2000;24(6):52-8.
5. Bogner R, Meghan F. Fast dissolving tablets. US Pharmacist 2005;27:03.
6. Sohi H, Sultana Y, Khar R. Taste masking technologies in oral pharmaceuticals: Recent development and approaches. Drug Dev Ind Pharm 2004;30:429-48.
7. Borodkin S, Sundberg D. Polycarboxylic acid ion-exchange adsorbates for taste coverage in chewable tablets. J Pharm Sci 1971;50:1523.
8. Avari J, Bhalekar M. Cation exchange resins for taste masking and rapid dissolution of sparfloxacin. Indian Drugs 2004;41(1):19-23.
9. Pisal S, Zainnuddin R, Nalawade P, Mahadik K, Kadam S. Molecular properties of ciprofloxacin-indion 234 complexes. AAPS PharmSciTech 2004;5(4):e62.
10. Chaudhari P, Chaudhari S, Lanke S, Patel N. Formulation and in vitro evaluation of taste masked orodispersible dosage form of Levocetirizine dihydrochloride. Indian J Pharm Edu Res 2007;41(4):319-28.
11. Kalsi P. Spectroscopic identification of organic compounds, 5th ed. New Delhi: New Age International Publishers; 2002. p. 84-102.
12. Skoog D, Holler F, Nieman T. The principles of instrumental analysis, 5th ed. Singapore: Thomson Book/Cole; 1998. p. 805-8.
13. Bolton S. Pharmaceutical statistics, 2nd ed. New York: Marcel Decker; 1990. p. 532-34.
14. Singh B, Ahuja N. Response surface optimization of drug delivery system. In: Jain NK, editor. Progress in controlled and novel drug delivery systems, 1st ed. New Delhi: CBS Publishers and Distributors; 2004. p. 470-509.
15. Singh B, Ahuja N. Development of controlled release buccoadhesive hydrophilic matrices of diltiazem hydrochloride: Optimization of bioadhesion, dissolution and diffusion parameters. Drug Dev Ind Pharm 2002;28:433-44.
16. Gohel M, Patel M, Agarwal R, Amin A, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. AAPS PharmSciTech 2004;5(3):36.
17. Lachmann L, Liberman H, Kanig J. The theory and practice of industrial pharmacy, 3rd edn. Mumbai: Varghese; 1987. p. 296-300.
18. Indian Pharmacopoeia 1996, vol I. The controller of publications, New Delhi.
19. Morita Y, Tsushima Y, Termoz R, Ajioka J, Takayama K. Evaluation of disintegration time of rapidly disintegrating tablets via a novel method using a CCD camera. Chem Pharm Bull (Tokyo) 2002;50:1181-6.
20. Watanabe Y, Yamamoti Y, Fujii M, Kondoh M, Shibata Y. A novel method for predicting disintegration time in the mouth of rapid disintegrating tablet by compaction analysis using Tab All. Chem Pharm Bull (Tokyo) 2004;52:1394-5.
21. Narazki R, Harada T, Takami N, Koto Y, Ohwaki T. A new method for disintegration studies of rapid disintegrating tablets. Chem Pharm Bull (Tokyo) 2004;52:704-7.
22. Kuchekar B, Badhan A, Mahajan H. Mouth dissolving tablets of salbutamol sulphate: A novel drug delivery system. Indian Drugs 2004;41(10):592-8.
23. United States Pharmacopoeia 29-NF 24. The Official Compendia of Standards. Asian ed. Rockville, MD: United States Pharmacopoeial Convention Inc.; 2006. p. 2679-2681.
24. Khan S, Kataria P, Nakhat P, Yeole P. Taste masking of Ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets. AAPS PharmSciTech 2007;8(2):e46.