Solitary Nocardia farcinica brain abscess in an immunocompetent adult mimicking metastatic brain tumor: rapid diagnosis by pyrosequencing and successful treatment

Surgical Neurology

Volumn 72, Issue 1, 2009, Pages 74-79

  Iannotti, Christopher A ^a   Hall, Geraldine S ^a   Procop, Gary W ^a   Tuohy, Marion J ^a   Staugaitis, Susan M ^a   Weil, Robert J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Awake craniotomy; Brain tumor; Cerebral abscess; Nocardia farcinica; Polymerase chain reaction (PCR); Pyrosequencing (PS)

Indexed keywords

AMIKACIN; CIPROFLOXACIN; CLARITHROMYCIN; COTRIMOXAZOLE; GADOLINIUM; IMIPENEM; LINEZOLID; TOBRAMYCIN;

ADULT; APHASIA; ARTICLE; BACTERIUM IDENTIFICATION; BRAIN ABSCESS; BRAIN EDEMA; BRAIN MAPPING; BRAIN TUMOR; CASE REPORT; CONFUSION; CRANIOTOMY; DIAGNOSTIC ACCURACY; DISORIENTATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FOCAL EPILEPSY; FRAMELESS STEREOTACTIC PROCEDURE; FROZEN SECTION; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENCE; LABORATORY TEST; LUNG NODULE; MALE; MOTOR CORTEX; NEUROLOGIC EXAMINATION; NOCARDIA FARCINICA; NOCARDIOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POSTOPERATIVE CARE; PYROSEQUENCING; SKIN ALLERGY; STAINING; TREATMENT OUTCOME; ULTRASOUND;

ANTI-BACTERIAL AGENTS; BRAIN; BRAIN ABSCESS; BRAIN NEOPLASMS; CARCINOMA; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC TECHNIQUES, NEUROLOGICAL; DNA, BACTERIAL; DRUG HYPERSENSITIVITY; EPILEPSY; GENOTYPE; HUMANS; IMMUNOCOMPETENCE; LUNG NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOLECULAR BIOLOGY; NEUROSURGICAL PROCEDURES; NOCARDIA; NOCARDIA INFECTIONS; TREATMENT OUTCOME;

EID: 67549117633     PISSN: 00903019     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surneu.2008.02.025     Document Type: Article

References (30)

1. Ahmadian A., Ehn M., and Hober S. Pyrosequencing: history, biochemistry and future. Clin Chim Acta 363 1-2 (2006) 83-94
2. Beaman B.L., and Beaman L. Nocardia species: host-parasite relationships. Clin Microbiol Rev 7 (1994) 213-264
3. Beaman B.L., Burnside J., Edwards B., et al. Nocardial infections in the United States, 1972-1974. J Infect Dis 134 (1976) 286-289
4. Brown-Elliott B.A., Brown J.M., Conville P.S., et al. Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 19 2 (2006) 259-282
5. Elahi E., and Ronaghi M. Pyrosequencing: a tool for DNA sequencing analysis. Methods Mol Biol 255 (2004) 211-219
6. Fihman V., Bercot B., Mateo J., et al. First successful treatment of Nocardia farcinica brain abscess with moxifloxacin. J Infect 52 4 (2006) 99-102
7. Fleetwood I.G., Embil J.M., and Ross I.B. Nocardia asteroides cerebral abscess in immunocompetent hosts: report of three cases and review of surgical recommendations. Surg Neurol 53 6 (2000) 605-610
8. Galor A., Hall G.S., Procop G.W., et al. Rapid species determination of nocardia keratitis using pyrosequencing technology. Am J Opthalmol 143 1 (2006) 182-183
9. Jonasson J., Olofsson M., and Monstein H.J. Classification, identification and subtyping of bacteria based on pyrosequencing and signature matches of 16S rDNA fragments. APMIS 110 (2002) 263-272
10. Kobayashi N., Bauer T.W., Togawa D., et al. A molecular gram stain using broad range PCR and pyrosequencing technology: a potentially useful tool for diagnosing orthopaedic infections. Diagn Mol Pathol 14 2 (2005) 83-89
11. Kobayashi N., Bauer T.W., Tuohy M.J., et al. The comparison of pyrosequencing molecular Gram stain, culture, and conventional Gram stain for diagnosing orthopaedic infections. J Orthop Res 24 8 (2006) 1641-1649
12. Malincarne L., Marroni M., Farina C., et al. Primary brain abscess with Nocardia farcinica in an immunocompetent patient. Clin Neurol Neurosurg 104 2 (2002) 132-135
13. Mamelak A.N., Obana W.G., Flaherty J.F., et al. Nocardia brain abscess: treatment strategies and factors influencing outcome. Neurosurgery 35 4 (1994) 622-631
14. Mamelak A.N., Mamalpam T., Obana W.G., et al. Improved management of multiple brain abscesses: a combined surgical and medical approach. Neurosurgery 36 1 (1995) 76-86
15. Mampalam T., and Rosenblum M.L. Trends in the management of bacterial brain abscesses: a review of 102 cases over 17 years. Neurosurgery 23 4 (1988) 451-458
16. Menku A., Kurtsoy A., Tucer B., et al. Nocardia brain abscess mimicking brain tumour in immunocompetent patients: report of two cases and review of the literature. Acta Neurochir (Wien) 146 4 (2004) 411-414
17. Lee G.Y., Daniel R.T., Brophy B.P., et al. Surgical treatment of nocardial brain abscesses. Neurosurgery 51 (2002) 668-671
18. Palmer D.L., Harvey R.L., and Wheeler J.K. Diagnostic and therapeutic considerations in Nocardia asteroides infection. Medicine 63 (1974) 391-401
19. Peters B.R., Saubolle M.A., and Costantino J.M. Disseminated and cerebral infection due to Nocardia farcinica: diagnosis by blood culture and cure with antibiotics alone. Clin Infect Dis 23 (1996) 1165-1167
20. Ronaghi M., Uhlen M., and Nyren P. A sequencing method based on real-time pyrophosphate. Science 281 5375 (1998) 363-365
21. Ronaghi M., and Elahi E.J. Pyrosequencing for microbial typing. Chromatogr B Analyt Technol Biomed Life Sci 782 1-2 (2002) 67-72
22. Ronaghi M. Pyrosequencing sheds light on DNA sequencing. Genome Res 11 1 (2001) 3-11
23. Sonesson A., Oqvist B., Hagstam P., et al. An immunosuppressed patient with systemic vasculitis suffering from cerebral abscesses due to Nocardia farcinica identified by 16S rRNA gene universal PCR. Nephrol Dial Transplant 19 11 (2004) 2896-2900
24. Sreekumar C., Hill D.E., Miska K.B., et al. Genotyping and detection of multiple infections of Toxoplasma gondii using pyrosequencing. Int J Parasitol 35 (2005) 991-999
25. Tarnberg M., Jakobsson T., Jonasson J., et al. Identification of randomly selected colonies of lactobacilli from normal vaginal fluid by pyrosequencing of the 16S rDNA variable V1 and V3 regions. APMIS 110 (2002) 802-810
26. Tuohy M.J., Hall G.S., Sholtis M., et al. Pyrosequencing as a tool for the identification of common isolates of Mycobacterium sp. Diagn Microbiol Infect Dis 51 4 (2005) 245-250
27. Unnerstad H., Ericsson H., Alderborn A., et al. Pyrosequencing as a method for grouping of Listeria monocytogenes strains on the basis of single-nucleotide polymorphisms in the inlB gene. Appl Environ Microbiol 67 11 (2001) 5339-5342
28. Valarezo J., Cohen J.E., Valarezo L., et al. Nocardial cerebral abscess: report of three cases and review of the current neurosurgical management. Neurol Res 25 1 (2003) 27-30
29. Vigano S.M., Edefonti A., Ferraresso M., et al. Successful medical treatment of multiple brain abscesses due to Nocardia farcinica in a paediatric renal transplant recipient. Pediatr Nephrol 20 8 (2005) 1186-1188
30. Wallace Jr. R.J., Tsukamura M., Brown B.A., et al. Cefotaxime-resistant Nocardia asteroides strains are isolates of the controversial species Nocardia farcinica. J Clin Microbiol 28 12 (1990) 2726-2732