Cardiac resynchronization therapy and the electrical substrate in heart failure: What does the QRS conceal?

Heart Rhythm

Volumn 6, Issue 7, 2009, Pages 1059-1062

  Varma, Niraj ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

CRT; Electrocardiographic imaging; Heart failure; LBBB; Ventricular activation

Indexed keywords

ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; CLINICAL FEATURE; ECHOCARDIOGRAPHY; ELECTRIC CONDUCTIVITY; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART HEMODYNAMICS; HEART VENTRICLE CONDUCTION; HEART VENTRICLE REMODELING; HUMAN; NERVE BLOCK; PRIORITY JOURNAL; QRS COMPLEX; TREATMENT RESPONSE;

BUNDLE-BRANCH BLOCK; CARDIAC PACING, ARTIFICIAL; ELECTROCARDIOGRAPHY; HEART FAILURE; HUMANS;

EID: 67549089542     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.03.052     Document Type: Article

References (21)

1. Baldasseroni S., Opasich C., Gorini M., et al. Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: a report from the Italian network on congestive heart failure. Am Heart J 143 (2002) 398-405
2. Cleland J.G., Daubert J.C., Erdmann E., et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352 (2005) 1539-1549
3. Varma N. Left ventricular conduction delays in response to right ventricular apical pacing. Influence of LV dysfunction and bundle branch block. J Cardiovasc Electrophsyiol 19 (2008) 114-122
4. Wilkoff B.L., Cook J.R., Epstein A.E., et al. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) trial. JAMA 288 (2002) 3115-3123
5. Durrer D., van Dam R.T., Freud G.E., Janse M.J., Meijler F.L., and Arzbaecher R.C. Total excitation of the isolated human heart. Circulation 41 (1970) 899-912
6. Auricchio A., Fantoni C., Regoli F., et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 109 (2004) 1133-1139
7. Vassallo J.A., Cassidy D.M., Marchlinski F.E., et al. Endocardial activation of left bundle branch block. Circulation 69 (1984) 914-923
8. Vassallo J.A., Cassidy D.M., Miller J.M., Buxton A.E., Marchlinski F.E., and Josephson M.E. Left ventricular endocardial activation during right ventricular pacing: effect of underlying heart disease. J Am Coll Cardiol 7 (1986) 1228-1233
9. Varma N. Left ventricular conduction delays and relation to QRS configuration in patients with left ventricular dysfunction. Am J Cardiol 103 (2009) 1578-1585
10. Abraham W.T., Fisher W.G., Smith A.L., et al. Cardiac resynchronization in chronic heart failure. N Engl J Med 346 (2002) 1845-1853
11. Kass D.A. Predicting cardiac resynchronization response by QRS duration: the long and short of it. J Am Coll Cardiol 42 (2003) 2125-2127
12. Chung E.S., Leon A.R., Tavazzi L., et al. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation 117 (2008) 2608-2616
13. Rodriguez L.M., Timmermans C., Nabar A., Beatty G., and Wellens H.J. Variable patterns of septal activation in patients with left bundle branch block and heart failure. J Cardiovasc Electrophysiol 14 (2003) 135-141
14. Jia P., Ramanathan C., Ghanem R.N., Ryu K., Varma N., and Rudy Y. Electrocardiographic imaging of cardiac resynchronization therapy in heart failure: observation of variable electrophysiologic responses. Heart Rhythm 3 (2006) 296-310
15. Bleeker G.B., Kaandorp T.A., Lamb H.J., et al. Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation 113 (2006) 969-976
16. Lambiase P.D., Rinaldi A., Hauck J., et al. Non-contact left ventricular endocardial mapping in cardiac resynchronisation therapy. Heart 90 (2004) 44-51
17. Spragg D.D., Akar F.G., Helm R.H., Tunin R.S., Tomaselli G.F., and Kass D.A. Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res 67 (2005) 77-86
18. Blanc J.J., Fatemi M., Bertault V., Baraket F., and Etienne Y. Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy with severe heart failure. A new concept of left ventricular dyssynchrony-induced cardiomyopathy. Europace 7 (2005) 604-610
19. Singh J.P., Fan D., Heist E.K., et al. Left ventricular lead electrical delay predicts response to cardiac resynchronization therapy. Heart Rhythm 3 (2006) 1285-1292
20. Ramanathan C., Ghanem R.N., Jia P., Ryu K., and Rudy Y. Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia. Nat Med 10 (2004) 422-428
21. Varma N., Jia P., and Rudy Y. Placebo CRT. J Cardiovasc Electrophysiol 19 (2008) 878