The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate

BMC Microbiology

Volumn 9, Issue , 2009, Pages

  Gristwood, Tamzin ^b   Fineran, Peter C ^b   Everson, Lee ^a   Williamson, Neil R ^a   Salmond, George P ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; BETA GALACTOSIDASE; BETA GLUCURONIDASE; CARBAPENEM; DNA; DRUG METABOLITE; PHOB PROTEIN; PHOSPHATE; PHOSPHATE TRANSPORTER; PRODIGIOSIN; PROTEIN HISTIDINE KINASE; RAP PROTEIN; RNA; SMAR PROTEIN; UNCLASSIFIED DRUG; ABC TRANSPORTER; BACTERIAL DNA; PHOB PROTEIN, BACTERIA; PSTC PROTEIN, BACTERIA; RAP PROTEIN, BACTERIA;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BACTERIUM MUTANT; BINDING AFFINITY; BIOSYNTHESIS; DNA BINDING; DNA SEQUENCE; ENTEROBACTERIACEAE; ENZYME ACTIVITY; ENZYME ASSAY; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; OPERON; PROMOTER REGION; QUORUM SENSING; SERRATIA; TRANSCRIPTION REGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTAGENESIS; MUTATION;

SERRATIA; SERRATIA SP. ATCC 39006;

ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; MUTAGENESIS; MUTATION; OPERON; PHOSPHATE TRANSPORT PROTEINS; PHOSPHATES; QUORUM SENSING; SERRATIA; TRANSCRIPTION, GENETIC;

EID: 67549086572     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-9-112     Document Type: Article

References (52)

1. Phosphorous assimilation and control of the phosphate regulon. BL Wanner, Escherichia coli and Salmonella: Cellular and Molecular Biology American Society for Microbiology, Washington, DC, Neidhart RCI, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbrager HE, 1996 1 1357 1381
2. Characterization of PitA and PitB from Escherichia coli. RM Harris DC Webb SM Howitt GB Cox, J Bacteriol 2001 183 17 5008 5014 11489853 10.1128/JB.183.17.5008-5014.2001
3. Two systems for the uptake of phosphate in Escherichia coli. H Rosenberg RG Gerdes K Chegwidden, J Bacteriol 1977 131 2 505 511 328484
4. Energy coupling to the transport of inorganic phosphate in Escherichia coli K12. H Rosenberg RG Gerdes FM Harold, Biochem J 1979 178 1 133 137 373750 (Pubitemid 9127590)
5. Nucleotide sequence of the genes involved in phosphate transport and regulation of the phosphate regulon in Escherichia coli. M Amemura K Makino H Shinagawa A Kobayashi A Nakata, J Mol Biol 1985 184 2 241 250 10.1016/0022-2836(85)90377-8 2993631
6. Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships. BP Surin H Rosenberg GB Cox, J Bacteriol 1985 161 1 189 198 3881386 (Pubitemid 15156117)
7. Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices. DC Webb H Rosenberg GB Cox, J Biol Chem 1992 267 34 24661 24668 1447208
8. Characterization of two genetically separable inorganic phosphate transport systems in Escherichia coli. GR Willsky MH Malamy, J Bacteriol 1980 144 1 356 365 6998957 (Pubitemid 11211056)
9. Regulation of the phosphate regulon of Escherichia coli: analysis of mutant phoB and phoR genes causing different phenotypes. M Yamada K Makino M Amemura H Shinagawa A Nakata, J Bacteriol 1989 171 10 5601 5606 2676981 (Pubitemid 19252446)
10. Regulation of the phosphate regulon of Escherichia coli: characterization of the promoter of the pstS gene. S Kimura K Makino H Shinagawa M Amemura A Nakata, Mol Gen Genet 1989 215 3 374 380 10.1007/BF00427032 2651888
11. Regulation of the phosphate regulon of Escherichia coli. Activation of pstS transcription by PhoB protein in vitro. K Makino H Shinagawa M Amemura S Kimura A Nakata A Ishihama, J Mol Biol 1988 203 1 85 95 10.1016/0022-2836(88) 90093-9 3054125
12. Nucleotide sequence of the phoB gene, the positive regulatory gene for the phosphate regulon of Escherichia coli K-12. K Makino H Shinagawa M Amemura A Nakata, J Mol Biol 1986 190 1 37 44 10.1016/0022-2836(86)90073-2 3537313
13. The signal-transduction network for Pho regulation in Bacillus subtilis. FM Hulett, Mol Microbiol 1996 19 5 933 939 10.1046/j.1365-2958.1996.421953.x 8830274 (Pubitemid 26083423)
14. Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor. A Sola-Landa A Rodriguez-Garcia AK Apel JF Martin, Nucleic Acids Res 2008 36 4 1358 1368 18187507 10.1093/nar/gkm1150
15. Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon. PM Steed BL Wanner, J Bacteriol 1993 175 21 6797 6809 8226621 (Pubitemid 23322428)
16. Fine tuning the specificity of the periplasmic phosphate transport receptor. Site-directed mutagenesis, ligand binding, and crystallographic studies. Z Wang A Choudhary PS Ledvina FA Quiocho, J Biol Chem 1994 269 40 25091 25094 7929197
17. Phosphate control of antibiotic biosynthesis at the transcriptional level. JF Martin AT Marcos A Martin JA Asturias P Liras, Washington, DC: American Society for Microbiology 1994
18. The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation. AK Harris NR Williamson H Slater A Cox S Abbasi I Foulds HT Simonsen FJ Leeper GP Salmond, Microbiology 2004 150 Pt 11 3547 3560 10.1099/mic.0.27222-0 15528645
19. Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhlA-dependent surfactant biosynthesis in Serratia. NR Williamson PC Fineran W Ogawa LR Woodley GP Salmond, Environ Microbiol 2008 10 5 1202 1217 10.1111/j.1462-2920.2007.01536.x 18294208
20. Synthesis, proton-affinity and anti-cancer properties of the prodigiosin-group natural products. RA Manderville, Curr Med Chem Anti-Canc Agents 2001 1 2 195 218 10.2174/1568011013354688
21. The prodigiosins, proapoptotic drugs with anticancer properties. R Perez-Tomas B Montaner E Llagostera V Soto-Cerrato, Biochem Pharmacol 2003 66 8 1447 1452 10.1016/S0006-2952(03)00496-9 14555220
22. Anticancer and immunosuppressive properties of bacterial prodiginines. NR Williamson PC Fineran T Gristwood SR Chawrai FJ Leeper GP Salmond, Future Microbiol 2007 2 605 618 10.2217/17460913.2.6.605 18041902
23. The biosynthetic implications of acetate and glutamate incorporation into (3R,5R)-carbapenam-3-carboxylic acid and (5R)-carbapen-2-em-3-carboxylic acid by Serratia sp. BW Bycroft C Maslen SJ Box A Brown JW Tyler, J Antibiot (Tokyo) 1988 41 9 1231 1242 3182403 (Pubitemid 18239637)
24. SQ 27,860, a simple carbapenem produced by species of Serratia and Erwinia. WL Parker ML Rathnum JS Wells Jr WH Trejo PA Principe RB Sykes, J Antibiot (Tokyo) 1982 35 6 653 660 7118721 (Pubitemid 13221967)
25. Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control. NR Thomson MA Crow SJ McGowan A Cox GP Salmond, Mol Microbiol 2000 36 3 539 556 10.1046/j.1365-2958.2000.01872.x 10844645
26. Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces. NR Williamson HT Simonsen RA Ahmed G Goldet H Slater L Woodley FJ Leeper GP Salmond, Mol Microbiol 2005 56 4 971 989 10.1111/j.1365-2958.2005.04602.x 15853884
27. The biosynthesis and regulation of bacterial prodiginines. NR Williamson PC Fineran FJ Leeper GP Salmond, Nat Rev Microbiol 2006 4 12 887 899 10.1038/nrmicro1531 17109029
28. Biosynthesis of tripyrrole and beta-lactam secondary metabolites in Serratia: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production. PC Fineran H Slater L Everson K Hughes GP Salmond, Mol Microbiol 2005 56 6 1495 1517 15916601 (Pubitemid 40780646)
29. Phosphate availability regulates biosynthesis of two antibiotics, prodigiosin and carbapenem, in Serratia via both quorum-sensing-dependent and -independent pathways. H Slater M Crow L Everson GP Salmond, Mol Microbiol 2003 47 2 303 320 10.1046/j.1365-2958.2003.03295.x 12519208
30. Quorum sensing in Serratia. R Van Houdt M Givskov CW Michiels, FEMS Microbiol Rev 2007 31 4 407 424 10.1111/j.1574-6976.2007.00071.x 17459113
31. The rap and hor proteins of Erwinia, Serratia and Yersinia: a novel subgroup in a growing superfamily of proteins regulating diverse physiological processes in bacterial pathogens. NR Thomson A Cox BW Bycroft GS Stewart P Williams GP Salmond, Mol Microbiol 1997 26 3 531 544 10.1046/j.1365-2958.1997. 5981976.x 9402023 (Pubitemid 27487851)
32. RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague. JS Cathelyn SD Crosby WW Lathem WE Goldman VL Miller, Proc Natl Acad Sci USA 2006 103 36 13514 13519 16938880 10.1073/pnas.0603456103
33. Invasin and beyond: regulation of Yersinia virulence by RovA. DW Ellison MB Lawrenz VL Miller, Trends Microbiol 2004 12 6 296 300 10.1016/j.tim.2004.04. 006 15165608
34. Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA, a transcriptional activator of the SlyA/Hor family. G Nagel A Lahrz P Dersch, Mol Microbiol 2001 41 6 1249 1269 10.1046/j.1365-2958.2001.02522.x 11580832
35. Virulence and prodigiosin antibiotic biosynthesis in Serratia are regulated pleiotropically by the GGDEF/EAL domain protein, PigX. PC Fineran NR Williamson KS Lilley GP Salmond, J Bacteriol 2007 189 21 7653 7662 17766413 10.1128/JB.00671-07
36. PigZ, a TetR/AcrR family repressor, modulates secondary metabolism via the expression of a putative four-component resistance-nodulation-cell-division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006. T Gristwood PC Fineran L Everson GP Salmond, Mol Microbiol 2008 69 2 418 435 10.1111/j.1365-2958.2008. 06291.x 18485072
37. Substrate analysis and molecular cloning of the extracellular alkaline phosphatase of Streptomyces griseus. RS Moura JF Martin A Martin P Liras, Microbiology 2001 147 Pt 6 1525 1533 11390683 (Pubitemid 32544817)
38. The acid-inducible asr gene in Escherichia coli: transcriptional control by the phoBR operon. E Suziedeliene K Suziedelis V Garbenciute S Normark, J Bacteriol 1999 181 7 2084 2093 10094685 (Pubitemid 29164961)
39. The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis. MG Lamarche BL Wanner S Crepin J Harel, FEMS Microbiol Rev 2008 32 3 461 473 10.1111/j.1574-6976.2008. 00101.x 18248418
40. Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story. JF Martin, J Bacteriol 2004 186 16 5197 5201 15292120 10.1128/JB.186.16.5197-5201.2004
41. The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. A Sola-Landa RS Moura JF Martin, Proc Natl Acad Sci USA 2003 100 10 6133 6138 12730372 10.1073/pnas.0931429100
42. The evolutionary role of secondary metabolites a review. RA Maplestone MJ Stone DH Williams, Gene 1992 115 1 151 157 10.1016/0378-1119(92)90553-2 1612430
43. Secondary metabolism, inventive evolution and biochemical diversity a review. LC Vining, Gene 1992 115 1 2 135 140 10.1016/0378-1119(92)90551-Y 1612428
44. Genetic analysis of pigment biosynthesis in Xanthobacter autotrophicus Py2 using a new, highly efficient transposon mutagenesis system that is functional in a wide variety of bacteria. RA Larsen MM Wilson AM Guss WW Metcalf, Arch Microbiol 2002 178 3 193 201 10.1007/s00203-002-0442-2 12189420
45. Transport of basic amino acids by the dinitrogen-fixing cyanobacterium Anabaena PCC 7120. A Herrero E Flores, J Biol Chem 1990 265 7 3931 3935 2105956
46. N-(3-oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora. NJ Bainton P Stead SR Chhabra BW Bycroft GP Salmond GS Stewart P Williams, Biochem J 1992 288 Pt 3 997 1004 1335238 (Pubitemid 23031787)
47. Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative eubacteria. V de Lorenzo M Herrero U Jakubzik KN Timmis, J Bacteriol 1990 172 11 6568 6572 2172217 (Pubitemid 20372802)
48. A GntR family transcriptional regulator (PigT) controls gluconate-mediated repression and defines a new, independent pathway for regulation of the tripyrrole antibiotic, prodigiosin, in Serratia. PC Fineran L Everson H Slater GP Salmond, Microbiology 2005 151 Pt 12 3833 3845 10.1099/mic.0.28251-0 16339930
49. Broad host range plasmids carrying the Escherichia coli lactose and galactose operons. J Lodge J Fear S Busby P Gunasekaran NR Kamini, FEMS Microbiol Lett 1992 74 2 3 271 276 10.1111/j.1574-6968.1992.tb05378.x 1526459
50. Molecular Cloning: a Laboratory Manual. J Sambrook EF Fritsch T Maniatis, New York, NY: Cold Spring Harbour Laboratory Press 2 1989
51. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. SF Altschul TL Madden AA Schaffer J Zhang Z Zhang W Miller DJ Lipman, Nucleic Acids Res 1997 25 17 3389 3402 9254694 10.1093/nar/25.17.3389
52. Analysis of the regulation of Escherichia coli alkaline phosphatase synthesis using deletions and phi80 transducing phages. E Brickman J Beckwith, J Mol Biol 1975 96 2 307 316 10.1016/0022-2836(75)90350-2 1100846