Tacrolimus Therapy in Adults With Steroid- and Cyclophosphamide-Resistant Nephrotic Syndrome and Normal or Mildly Reduced GFR

American Journal of Kidney Diseases

Volumn 54, Issue 1, 2009, Pages 51-58

  Li, Xiayu ^a   Li, Heng ^a   Ye, Huijuan ^a   Li, Qun ^a   He, Xuelin ^a   Zhang, Xiaohui ^a   Chen, Yilun ^a   Han, Fei ^a   He, Qiang ^a   Wang, Huipin ^a   Chen, Jianghua ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

idiopathic nephrotic syndrome; intravenous cyclophosphamide; steroid resistance; Tacrolimus

Indexed keywords

CREATININE; CYCLOPHOSPHAMIDE; PREDNISONE; TACROLIMUS;

ADULT; ARTICLE; BACTERIAL PNEUMONIA; CLINICAL ARTICLE; CLINICAL TRIAL; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIARRHEA; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; FOCAL GLOMERULOSCLEROSIS; FOLLOW UP; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; HUMAN; HYPERTENSION; KIDNEY FUNCTION; LIVER TOXICITY; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MINIMAL CHANGE NEPHROPATHY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEPHROTIC SYNDROME; NEPHROTOXICITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; PROTEINURIA; RELAPSE; REMISSION; URINARY TRACT INFECTION; VOMITING;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; CHINA; CREATININE; CYCLOPHOSPHAMIDE; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; MALE; NEPHROSIS, LIPOID; NEPHROTIC SYNDROME; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; STEROIDS; TACROLIMUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 67449152260     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.02.018     Document Type: Article

References (25)

1. Habashy D., Hodson E.M., and Craig J.C. Interventions for steroid-resistant nephrotic syndrome: A systematic review. Pediatr Nephrol 18 (2003) 906-912
2. Waldman M., Crew R.J., Valeri A., et al. Adult minimal-change disease: Clinical characteristics, treatment, and outcomes. Clin J Am Soc Nephrol 2 (2007) 445-453
3. Cattran D.C., Appel G.B., Hebert L.A., et al. A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis. North America Nephrotic Syndrome Study Group. Kidney Int 56 (1999) 2220-2226
4. Bajpai A., Bagga A., Hari P., Dinda A., and Srivastava R.N. Intravenous cyclophosphamide in steroid-resistant nephrotic syndrome. Pediatr Nephrol 18 (2003) 351-356
5. Kirpekar R., Yorgin P.D., Tune B.M., Kim M.K., and Sibley R.K. Clinicopathologic correlates predict the outcome in children with steroid-resistant idiopathic nephrotic syndrome treated with pulse methylprednisolone therapy. Am J Kidney Dis 39 (1992) 1143-1152
6. Ponticelli C., Rizzoni G., Edefonti A., et al. A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome. Kidney Int 43 (1993) 1377-1384
7. Mendizabal S., Zamora I., Berbel O., Sanahuja M.J., Fuentes J., and Simon J. Mycophenolate mofetil in steroid/cyclosporine-dependent/resistant nephrotic syndrome. Pediatr Nephrol 20 (2005) 914-919
8. Tarshich P., Tokin J.N., Remstein J., et al. Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis: A report of the International Study of Kidney Disease in Children. Pediatr Nephrol 10 (1996) 590-593
9. Denton M.D., Magee C.C., and Sayegh M.H. Immunosuppressive strategies in transplantation. Lancet 353 (1999) 1083-1091
10. Budde K., Fritsche L., and Neumayer H.H. Differing proteinuria control with cyclosporine and tacrolimus. Lancet 349 (1997) 330
11. Schweda F., Liebl R., Riegger A.J., and Kramer B.K. Tacrolimus treatment for steroid-and cyclosporin-resistant minimal-change nephrotic syndrome. Nephrol Dial Transplant 12 (1997) 2433-2435
12. Duncan N., Dhaygude A., Owen J., et al. Treatment of focal and segmental glomerulosclerosis in adults with tacrolimus monotherapy. Nephrol Dial Transplant 19 (2004) 3062-3067
13. Segarra A., Vila J., Pou L., et al. Combined therapy of tacrolimus and corticosteroids in cyclosporin-resistant or -dependent idiopathic focal glomerulosclerosis: A preliminary uncontrolled study with prospective follow-up. Nephrol Dial Transplant 17 (2002) 655-662
14. Gulati S., Prasad N., Sharma R.K., Kumar A., Gupta A., and Baburai V.P. Tacrolimus: A new therapy for steroid-resistant nephrotic syndrome in children. Nephrol Dial Transplant 23 (2008) 910-913
15. Li X., Li H., Chen J., et al. Tacrolimus as a steroid-sparing agent for adults with steroid-dependent minimal change nephrotic syndrome. Nephrol Dial Transplant 23 (2008) 1919-1925
16. Li X., Lv R., He Q., et al. Early initiation of therapy tacrolimus or cyclophosphamide for idiopathic membranous nephropathy with severe proteinuria. J Nephrol 21 (2008) 584-591
17. Korbet S.M., Schwartz M.M., Lewis E.J., et al. Primary focal segmental glomerulosclerosis: Clinical course and response to therapy. Am J Kidney Dis 23 (1994) 773-783
18. Lieberman K.V., and Tejani A. A randomized double-blind placebo-controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children. J Am Soc Nephrol 7 (1996) 56-63
19. Chamienia A., Biedunkiewicz B., Krol E., Debska-Slizien A., and Rutkowski B. One-year observation of kidney allograft recipients converted from cyclosporine microemulsion to tacrolimus. Transplant Proc 38 (2006) 81-85
20. Falkiewicz K., Kaninska D., Nahaczewska W., et al. Renal function and tubular phosphate handling in long-term cyclosporine-and tacrolimus-based immunosuppression in kidney transplantation. Transplant Proc 38 (2006) 119-122
21. Sinha M.D., Macleod R., Rigby E., and Clark A.G.B. Treatment of severe steroid-dependent nephrotic syndrome (SDNS) in children with tacrolimus. Nephrol Dial Transplant 21 (2006) 1848-1854
22. Faul C., Donnelly M., Merscher-Gomez S., et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 14 (2008) 931-938
23. Peters D.H., Fitton A., Plosker G.L., and Faulds D. Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs 46 (1993) 746-794
24. Tang S., Tang A.W., Tam M.K., and Ho Y.W. Use of tacrolimus in steroid-and cyclosporin-resistant minimal-change nephrotic syndrome. Am J Kidney Dis 75 (2003) 199-204
25. Loeffler K., Gowrishankar M., and Yiu V. Tacrolimus therapy in pediatric patients with treatment-resistant nephrotic syndrome. Pediatr Nephrol 19 (2004) 281-287