In vivo evaluation of thiolated poly(acrylic acid) as a drug absorption modulator for MRP2 efflux pump substrates

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 3, 2009, Pages 561-566

  Greindl, Melanie ^a   Föger, Florian ^a   Hombach, Juliane ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

MRP2; MRP2 inhibition; Poly(acrylic acid); Sulforhodamine; Thiomers

Indexed keywords

DRUG; MULTIDRUG RESISTANCE PROTEIN 2; POLYACRYLIC ACID; RHODAMINE; SULFORHODAMINE 101; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT;

ACRYLIC RESINS; ANIMALS; DRUG EVALUATION, PRECLINICAL; INTESTINAL ABSORPTION; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

EID: 67449146898     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.03.008     Document Type: Article

References (36)

1. Evers R., Kool M., Van Deemter L., Janssen H., Calafat J., Oomen L.C., Paulusma C.C., Oude Elferink R.P., Baas D., Schinkel A.H., and Borst P. Drug export activity of the human canalicular multispecific organic anion transporter in polarised kidney MDCK cells expressing cMOAT (MRP2) cDNA. J. Clin. Invest. 101 (1998) 1310-1319
2. Fromm M.F., Kauffmann H.M., Fritz P., Burk O., Kroemer H.K., Warzok R.W., Eichelbaum M., Siegmund W., and Schrenk D. The effect of rifampin treatment on intestinal expression of human MRP transporters. Am. J. Pathol. 157 (2000) 1575-1580
3. Walgren R.A., Karnaky K.J., Lindenmayer G.E., and Walle T. Efflux of dietary flavonoid quercetin 4́-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2a. J. Pharmacol. Exp. Ther. 294 (2000) 830-836
4. Takano M., Yumoto R., and Murakami T. Expression and function of efflux drug transporters in the intestine. Pharmacol. Ther. 109 (2006) 137-161
5. Jain R., Agarwal S., Majumdar S., Zhu X., Pal D., and Mitra A.K. Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification. Int. J. Pharm. 303 (2005) 8-19
6. Suzuki H., and Sugiyama Y. Single nucleotide polymorphismus in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition. Adv. Drug Deliv. Rev. 54 (2002) 1311-1331
7. Chan L.M., Lowes S., and Hirst B.H. The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur. J. Pharm. Sci. 21 (2004) 25-51
8. Hesselink D.A., Van Hest R.M., Mathot R.A., Bonthuis F., Weimar W., De Bruin R.W., and Van Gelder T. Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2. Am. J. Transplant. 5 (2005) 987-994
9. Borchard G., and Junginger H.E. Modern drug delivery applications of chitosan. Adv. Drug Deliv. Rev. 52 (2001) 103
10. Bernkop-Schnürch A., Schwarz V., and Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers?. Pharm. Res. 16 (1999) 876-881
11. Bravo-Osuna I., Schmitz T., Bernkop-Schnürch A., Vauthier C., and Ponchel G. Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles. Int. J. Pharm. 316 (2006) 170-175
12. Föger F., Schmitz T., and Bernkop-Schnürch A. In vivo evaluation of polymeric delivery systems for P-glycoprotein substrates. Biomaterials 27 (2006) 4250-4255
13. Föger F., Hoyer H., Kafedjiiski K., Thaurer M., and Bernkop-Schnürch A. In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials 27 (2006) 5855-5860
14. Miller D.S., Masereeuw R., and Karnaky K.J. Regulation of MRP2-mediated transport in shark rectal salt gland tubules. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 (2002) R774-R781
15. Marschütz M.K., and Bernkop-Schnürch A. Thiolated polymers: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur. J. Pharm. Sci. 15 (2002) 387-394
16. Leitner V.M., Marschütz M.K., and Bernkop-Schnürch A. Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass. Eur. J. Pharm. Sci. 92 (2003) 89-96
17. Miller D.S., Masereeuw R., Henson J., and Karnaky K.J. Excretory transport of xenobiotics by dogfish shark rectal gland tubules. Am. J. Physiol. 275 (1998) R697-R705
18. Masereeuw R., Russel F.G.M., and Miller D.S. Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy. Am. J. Physiol. Ren. Physiol. 40 (1996) F1173-F1182
19. Yokooji T., Murakami T., Yumoto R., Nagai J., and Takano M. Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. J. Pharm. Pharmacol. 59 (2007) 513-520
20. Cao X.H., Gibbs S.T., Fang L.Y., Miller H.A., Landowski C.P., Shin H.C., Lennernäs H., Zhong Y.Q., Amidon G.L., Yu L.X., and Sun D.X. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm. Res. 23 (2006) 1675-1686
21. Kruh G.D., and Belinsky M.G. The MRP family of drug efflux pumps. Oncogene 22 (2003) 7537-7552
22. Naruhashi K., Tamai I., Inoue N., Muraoka H., Sai Y., Suzuki N., and Tsuji A. Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. Antimicrob. Agents Chemoth. 46 (2002) 344-349
23. Legen I., and Kristl A. d-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro. Pharm. Res. 21 (2004) 635-640
24. Bernkop-Schnürch A., Hoffer M.H., and Kafedjiiski K. Thiomers for oral delivery of hydrophilic macromolecular drugs. Expert Opin. Drug Deliv. 1 (2004) 87-98
25. Werle M., and Hoffer M. Gluthatione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. J. Control Rel. 111 (2006) 41-46
26. Lo Y.L., and Huang J.D. Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats. Biochem. Pharmacol. 59 (2000) 665-672
27. Demina T., Grozdova I., Krylova O., Zhirnov A., Istratov V., Frey H., Kautz H., and Melik-Nubarov N. Relationship between the structure of amphiphilic copolymers and their ability to disturb lipid bilayers. Biochemistry 44 (2005) 4042-4054
28. Bernkop-Schnürch A., and Grabovac V. Polymeric efflux pump inhibitors in oral drug delivery. Am. J. Drug Deliv. 4 (2006) 263-272
29. Keppler D., and König J. Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J. 11 (1997) 509-516
30. Büchler M., König J., Brom M., Kartenbeck J., Spring H., Horie T., and Keppler D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 271 (1996) 15091-15098
31. Kast C.E., and Bernkop-Schnürch A. Influence of the molecular mass on the permeation enhancing effect of different poly(acrylates). Stp. Pharm. Sci. 12 (2002) 351-356
32. Grabovac V., Guggi D., and Bernkop-Schnürch A. Comparison of the mucoadhesive properties of various polymers. Adv. Drug Deliv. Rev. 57 (2005) 1713-1723
33. Leitner V.M., Guggi D., Krauland A.H., and Bernkop-Schnürch A. Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system. J. Control Rel. 100 (2004) 87-95
34. B. Carreno-Gomez, Duncan R, Compositions with enhanced oral bioavailibilty, U.S. Patent 424, 87, 17, 2000.
35. Usansky H.H., Hu P., and Sinko P.J. Differential roles of P-glycoprotein, multidrug resistance-associated protein 2 and CYP3A on Saquinavir oral absorption in Sprague-Dawley rats. Drug Metabol. Dispos. 36 (2008) 863-869
36. Dietrich C.G., Geier A., and Oude Elferink R.P. ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut 52 (2003) 1788-1795