Neonatal maternal separation increases brain-derived neurotrophic factor and tyrosine kinase receptor B expression in the descending pain modulatory system

NeuroSignals

Volumn 17, Issue 3, 2009, Pages 213-221

  Chung, Elaine K Y ^a   Bian, Zhao Xiang ^a   Xu, Hong Xi ^b   Sung, Joseph Jao Yiu ^c  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Amygdala; Brain derived neurotrophic factor; Colorectal distention; Neonatal maternal separation; Rostral ventromedial medulla; Tyrosine kinase receptor B

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; PROTEIN TYROSINE KINASE A;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; COLON DILATATION; CONTROLLED STUDY; FEMALE; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; MATERNAL DEPRIVATION; NEONATAL MATERNAL SEPARATION; NERVE CELL PLASTICITY; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; VISCERAL PAIN;

AMYGDALA; ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; EFFERENT PATHWAYS; FEMALE; HYPERALGESIA; MATERNAL DEPRIVATION; MEDULLA OBLONGATA; NOCICEPTORS; PAIN; RATS; RATS, WISTAR; RECEPTOR, TRKB; RETICULAR FORMATION; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; VISCERAL AFFERENTS;

EID: 67449143086     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000224631     Document Type: Article

References (35)

1. Liu D, Caldji C, Sharma S, Plotsky PM, Meaney MJ: Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherine release in the hypothalamic paraventricular nucleus. J Neuroendocrinol 2000; 12: 5-12. (Pubitemid 30098930)
2. Caldji C, Tannenbaum B, Sharma S, Francis D, Plotsky PM, Meaney MJ: Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc Natl Acad Sci USA 1998; 95: 5335-5340. (Pubitemid 28208598)
3. Coutinho SV, Plotsky PM, Sablad M, Miller JC, Zhou H, Bayati AI, McRoberts JA, Mayer EA: Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol 2002; 282:G307-G316. (Pubitemid 34651687)
4. Chung EK, Zhang X, Li Z, Zhang H, Xu H, Bian Z: Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat. Brain Res 2007; 1153: 68-77. (Pubitemid 46802528)
5. Zhang XJ, Li Z, Chung EK, Zhang HQ, Xu HX, Sung JJ, Bian ZX: Activation of extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. J Mol Neurosci 2008; 37: 274-287.
6. Jones MP, Dilley JB, Drossman D, Crowell MD: Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 2006; 18: 91-103.
7. Mayer EA: Spinal and supraspinal modulation of visceral sensation. Gut 2000; 47(suppl 4):iv69-iv72.
8. Neugebauer V: The amygdala: different pains, different mechanisms. Pain 2007; 127: 1-2.
9. Phelps EA, LeDoux JE: Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 2005; 48: 175-187.
10. Kalin NH, Shelton SE, Davidson RJ: The role of the central nucleus of the amygdala in mediating fear and anxiety in the primate. J Neurosci 2004; 24: 5506-5515.
11. Fields HL: Pain modulation: expectation, opioid analgesia and virtual pain. Prog Brain Res 2000; 122: 245-253.
12. McGaraughty S, Heinricher MM: Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity. Pain 2002; 96: 153-162. (Pubitemid 34270636)
13. Neugebauer V, Li W, Bird GC, Han JS: The amygdala and persistent pain. Neuroscientist 2004; 10: 221-234.
14. Rosen JB, Schulkin J: From normal fear to pathological anxiety. Psychol Rev 1998; 105: 325-350.
15. Han JS, Li W, Neugebauer V: Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior. J Neurosci 2005; 25: 10717-10728. (Pubitemid 41681920)
16. Han JS, Neugebauer V: mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain. Pain 2005; 113: 211-222.
17. Pedersen LH, Scheel-Kruger J, Blackburn-Munro G: Amygdala GABA-A receptor involvement in mediating sensory-discriminative and affective-motivational pain responses in a rat model of peripheral nerve injury. Pain 2007; 127: 17-26. (Pubitemid 44959429)
18. Tanimoto S, Nakagawa T, Yamauchi Y, Minami M, Satoh M: Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats. Eur J Neurosci 2003; 18: 2343-2350. (Pubitemid 38117408)
19. Ikeda R, Takahashi Y, Inoue K, Kato F: NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain. Pain 2007; 127: 161-172. (Pubitemid 44959439)
20. Carrasquillo Y, Gereau RW: Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception. J Neurosci 2007; 27: 1543-1551. (Pubitemid 46280074)
21. Ou LC, Gean PW: Regulation of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol-3-kinase. Neuropsychopharmacology 2006; 31: 287-296.
22. Zhuo M, Sengupta JN, Gebhart GF: Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat. J Neurophysiol 2002; 87: 2225-2236. (Pubitemid 34670697)
23. Zhuo M, Gebhart GF: Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat. Gastroenterology 2002; 122: 1007-1019. (Pubitemid 34267284)
24. Chung EK, Zhang XJ, Xu HX, Sung JJ, Bian ZX: Visceral hyperalgesia induced by neonatal maternal separation is associated with nerve growth factor-mediated central neuronal plasticity in rat spinal cord. Neuroscience 2007; 149: 685-695.
25. Bekinschtein P, Cammarota M, Izquierdo I, Medina JH: BDNF and memory formation and storage. Neuroscientist 2008; 14: 147-156.
26. Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B: Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 1996; 381: 706-709. (Pubitemid 26196571)
27. Lu B, Chow A: Neurotrophins and hippocampal synaptic transmission and plasticity. J Neurosci Res 1999; 58: 76-87. (Pubitemid 29463694)
28. Ren K, Dubner R: Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors. Mol Neurobiol 2007; 35: 224-235. (Pubitemid 350129684)
29. Lippmann M, Bress A, Nemeroff CB, Plotsky PM, Monteggia LM: Long-term behavioural and molecular alterations associated with maternal separation in rats. Eur J Neurosci 2007; 25: 3091-3098. (Pubitemid 46888796)
30. Guo W, Robbins MT, Wei F, Zou S, Dubner R, Ren K: Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. J Neurosci 2006; 26: 126-137. (Pubitemid 43089525)
31. Barreau F, Ferrier L, Fioramonti J, Bueno L: Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats. Gut 2004; 53: 501-506. (Pubitemid 38372973)
32. Stam R, Ekkelenkamp K, Frankhuijzen AC, Bruijnzeel AW, Akkermans LM, Wiegant VM: Long-lasting changes in central nervous system responsivity to colonic distention after stress in rats. Gastroenterology 2002; 123: 1216-1225.
33. Greisen MH, Altar CA, Bolwig TG, Whitehead R, Wortwein G: Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats. J Neurosci Res 2005; 79: 772-778. (Pubitemid 40476501)
34. Schulte-Herbruggen O, Chourbaji S, Ridder S, Brandwein C, Gass P, Hortnagl H, Hellweg R: Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function. Psychoneuroendocrinology 2006; 31: 1266-1277. (Pubitemid 44803085)
35. Aguilar-Valles A, Sanchez E, de Gortari P, Balderas I, Ramirez-Amaya V, Bermudez-Rattoni F, Joseph-Bravo P: Analysis of the stress response in rats trained in the watermaze: differential expression of corticotropin-releasing hormone, CRH-R1, glucocorticoid receptors and brain-derived neurotrophic factor in limbic regions. Neuroendocrinology 2005; 82: 306-319. (Pubitemid 43800877)