A new sensitive imaging biomarker for Parkinson disease?

Neurology

Volumn 72, Issue 16, 2009, Pages 1374-1375

  Lang, Anthony E ^a,b   Mikulis, David ^a,b  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER; DOPAMINE; IRON;

ANISOTROPY; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIFFUSION TENSOR IMAGING; DISEASE MARKER; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; EDITORIAL; FRACTIONAL ANISOTROPY; HUMAN; NEUROIMAGING; NIGRONEOSTRIATAL SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SUBSTANTIA NIGRA; ANIMAL; ARTIFACT; DIFFERENTIAL DIAGNOSIS; DIFFUSION; DIFFUSION WEIGHTED IMAGING; DISEASE COURSE; DISEASE MODEL; EARLY DIAGNOSIS; INSTRUMENTATION; METABOLISM; METHODOLOGY; NERVE TRACT; NOTE; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; REPRODUCIBILITY;

ANIMALS; ARTIFACTS; BIOLOGICAL MARKERS; DIAGNOSIS, DIFFERENTIAL; DIFFUSION; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EARLY DIAGNOSIS; HUMANS; IRON; NEURAL PATHWAYS; PARKINSON DISEASE; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SUBSTANTIA NIGRA;

EID: 67449128402     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000343512.36654.41     Document Type: Editorial

References (9)

1. Brooks DJ, Frey KA, Marek KL, et al. Assessment of neu-roimaging techniques as biomarkers of the progression of Parkinson's disease. Exp Neurol 2003;184:S68-S79.
2. Huang CR, Tang CK, Feigin A, et al. Changes in network activity with the progression of Parkinson's disease. Brain 2007;130:1834-1846.
3. Duguid JR, De La Paz R, DeGroot J. Magnetic resonance imaging of the midbrain in Parkinson's disease. Ann Neurol 1986;20:744-747.
4. Chan LL, Rumpel H, Yap K, et al. Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007;78:1383-1386.
5. Yoshikawa K, Nakata Y, Yamada K, Nakagawa M. Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI. J Neurol Neurosurg Psychiatry 2004;75:481-484.
6. Vaillancourt DE, Spraker MB, Prodoehl J, et al. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 2009;72: 1378-1384.
7. Boska MD, Hasan KM, Kibuule D, et al. Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiol Dis 2007;26:590-596.
8. Martin WR, Wieler M, Gee M. Midbrain iron content in early Parkinson disease. Neurology 2008;70:1411-1417.
9. Braak H, Del Tredici K, Rüb U, De Vos RAI, Steur ENHJ, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24: 197-211.