The use of azythromycin and N-methyl glucamine for the treatment of cutaneous Leishmaniasis caused by Leishmania (Leishmania) amazonensis in C57BL6 mice;O uso da associação azitromicina e N-metil glucamina no tratamento da leishmaniose cutânea causada por Leishmania (Leishmania) amazonensis em camundongos C57BL6

Anais Brasileiros de Dermatologia

Volumn 84, Issue 2, 2009, Pages 125-128

  Sampaio, Raimunda Nonata Ribeiro ^a,b   Lucas, Íris Campos ^a   Da Costa Filho, Arnoldo Velloso ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b Hospital Universitário de Brasília ^*  (Brazil)

Author keywords

Azythromycin; Leishmaniasis, cutaneous; Leishmaniasis, cutaneous therapy

Indexed keywords

AZITHROMYCIN; MEGLUMINE ANTIMONATE;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CLINICAL EVALUATION; CONTROLLED STUDY; CULTURE TECHNIQUE; DILUTION; DRUG EFFICACY; EXPERIMENTAL MODEL; INOCULATION; LEISHMANIA; MALE; MOUSE; NONHUMAN; PARASITE CULTIVATION; SKIN LEISHMANIASIS; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANIMALS; ANTIMONY; ANTIPROTOZOAL AGENTS; AZITHROMYCIN; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; LEISHMANIASIS, CUTANEOUS; MALE; MEGLUMINE; MICE; MICE, INBRED C57BL; RANDOM ALLOCATION;

EID: 67449126292     PISSN: 03650596     EISSN: 18064841     Source Type: Journal    
DOI: 10.1590/S0365-05962009000200004     Document Type: Article

References (13)

1. Sampaio RNR, Sampaio JHD, Marsden PD. Pentavalent antimonial treatment in mucosal leishmaniasis. Lancet. 1985;1:1097. (Pubitemid 15075527)
2. Netto PD, Marsden PD, Llanos-Cuentas EA, Costa JML, Cuba CC, Barreto AC, et al. Long Term follow-up of Patients with Leishmania (Viannia) braziliensis infection and treated with Glucantime?. Trans Royal Soc Trop Med Hyg. 1990;84:367-370 (Pubitemid 20204315)
3. Sampaio RNR, Marsden PD, Furtado T, Sampaio JHD. Avaliação do tratamento da leishmaniose cutâneomucosa com três esquemas diferentes de antimoniais pentavalentes. An Bras Dermatol. 1989;64:201-205
4. Grogl M, Thomason TN, Franke ED. Drug resistance in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous disease. Am Soc Trop Med Hyg. 1992;47:117-126
5. Krolewiecki A, Leon S, Scott P, Abraham D. Activity of azithromycin against Leishmania major in vitro and in vivo. Am J Trop Med Hyg. 2002; 67: 273-277 (Pubitemid 35178351)
6. Retsema J, Wenchi F. Macrolides: structures and microbial targets. Int J Antim Agents. 2001;18:S3-S10.
7. Prata A, Silva-Vergara ML, Rocha A, Krolewiecki SJC, De-Paula EV, Pimenta FG, et al. Eficácia da azitromicina no tratamento da leishmaniose cutânea. Rev Soc Bras Med Trop. 2003;36:65-69
8. Tanyusel M, Bas AL, Araz E, Aybay C. Determination of intracellular efficacies of azithromycin against Leishmania major infection in human neutrophils in vitro. Cell Bioch Fun. 2003;21:93-96 (Pubitemid 36227833)
9. Michie C. Anti-inflammatory activity of macrolide antibiotics. Trends Mol Med. 2002;18:547. (Pubitemid 35408210)
10. Oliveira-Silva F, Pontes LA, Rabello A. In vitro activity of azithromycin against new world Leishmania species. Abstract Book of Third World Congress on Leishmaniosis. Palermo- Terrasini, Sicily, Italy: Editora of the Veterinary Institut of Palermo; 2005. p. 25.
11. Teixeira AC. Avaliação da eficácia da azitromicina no tratamento da leishmaniose cutânea em Manaus, Amazonas, Brasil [dissertação]. Faculdade de Medicina do Triângulo Mineiro Uberaba (MG): Faculdade de Medicina do Triângulo Mineiro; 2003.
12. Silva-Vergara ML, Silva LA, Maneira FR. Azithromycin in the treatment of mucosal leishmaniasis. Rev Inst Med Trop Sao Paulo. 2004;46:175-177 (Pubitemid 38917743)
13. Lima HC, Bleyenberg JA, Titus RG. A simple method for quantifying leishmania in tissues of infected animals. Parasitol Today. 1997;13:80-82 (Pubitemid 27080903)