Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

Journal of Gastroenterology

Volumn 44, Issue 6, 2009, Pages 624-629

  Eguchi, Susumu ^a   Hidaka, Masaaki ^a   Tomonaga, Tetsuo ^a   Miyazaki, Kensuke ^a   Inokuma, Takamitsu ^a   Takatsuki, Mitsuhisa ^a   Okudaira, Sadayuki ^a   Yamanouchi, Kosho ^a   Miyaaki, Hisamitsu ^a   Ichikawa, Tatsuki ^a   Tajima, Yoshitsugu ^a   Kanematsu, Takashi ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

HCC; Pre LT; Recurrence

Indexed keywords

ALCOHOL;

ADULT; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; CANCER THERAPY; CHEMOEMBOLIZATION; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; LIVER CELL CARCINOMA; LIVER NECROSIS; LIVER RESECTION; LIVER TRANSPLANTATION; LIVING DONOR; MALE; MINIMAL RESIDUAL DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PERCUTANEOUS ETHANOL INJECTION; PREOPERATIVE EVALUATION; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; SALVAGE THERAPY; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT RESPONSE;

CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; CHEMOEMBOLIZATION, THERAPEUTIC; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; ETHANOL; FATAL OUTCOME; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; NECROSIS; PERITONEAL NEOPLASMS; SALVAGE THERAPY;

EID: 67449108378     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-009-0043-9     Document Type: Article

References (23)

1. Eguchi S, Kanematsu T, Arii S, et al. Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey. Surgery. 2008;143:469-75.
2. Takayasu K, Arii S, Ikai I, et al. Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology. 2006;131:461-9.
3. Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L, Rossi S. Sustained complete response and complications rate after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice? Hepatology. 2008;47:82-9.
4. Belghiti J, Cortes A, Abdalla EK, et al. Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg. 2003;238:885-93.
5. Nicoli N, Casaril A, Hilal MA, et al. A case of rapid intrahepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation. Am J Surg. 2004;188:165-7.
6. Ishii H, Okada S, Okusaka T, et al. Needle tract implantation of hepatocellular carcinoma after percutaneous ethanol injection. Cancer. 1998;82:1638-42.
7. Koda M, Maeda Y, Matsunaga Y, et al. Hepatocellular carcinoma with sarcomatous change arising after radiofrequency ablation for well-differentiated hepatocellular carcinoma. Hepatol Res. 2003;27:163-7.
8. Docaens T, Roudot-Thoraval F, et al. Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatcellular carcinoma. Liver Transpl. 2005;11:767-75.
9. Rovaioli M, Grazi GL, Ercolani G, et al. Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation. Transplantation. 2004;78:1780-6.
10. Liou TC, Shih SC, Kao CR, Chou SY, Lin SC, Wang HY. Pulmonary metastasis of hepatocellular carcinoma associated with transarterial chemoembolization. J Hepatol. 1995;23:563-8.
11. Bharat A, Brown DB, Crippin JS, et al. Pre-liver transplantation locoregional adjuvant therapy for hepatocellular carcinoma as a strategy to improve longterm survival. J Am Coll Surg. 2006;203:411-20.
12. Yao FY, Kinkhabwala M, LaBerge JM, et al. The impact of pre-operative loco-regional therapy on outcome after liver transplantation for hepatocellular carcinoma. Am J Transplant. 2005;5:795-804.
13. Millonig G, Graziadei IW, Freund MC, et al. Response to preoperative chemoembolization for hepatocellular carcinoma. Liver Transpl. 2007;13:272-9.
14. Lu DS, Yu NC, Raman SS, et al. Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation. Hepatology. 2005;41:1130-7.
15. Mazzaferro V, Battiston C, Perrone S, et al. Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: A prospective study. Ann Surg. 2004;240:900-9.
16. Hidaka M, Eguchi S, Okudaira S, et al.: Multicentric occurence and spread of hepatocellular carcinoma in whole explanted end-stage liver. Hepatol Res. 2009;39:143-8.
17. The Liver Cancer Study Group of Japan. Classification of primary liver cancer. 1st English ed. Tokyo: Kanehara & Company Ltd.; 1997.
18. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Eng J Med. 1996;334:693-9.
19. Kim SH, Choi BI, et al. Diagnostic accuracy of multi-/single-detector row CT and contrast-enhanced MRI in the detection of hepatocellular carcinomas meeting the Milan criteria before liver transplantation. Intervirology. 2008;51(Suppl 1):52-60.
20. Pompili M, Mirante VG, Rondinara G, et al. Percutaneous ablation procedure in cirrhotic patients with hepatocellular carcinoma submitted to liver transplantation: Assessment of efficacy at explant analysis and of safety for tumor recurrence. Liver Transpl. 2005;11:1117-26.
21. Wong LL, Tanaka K, Lau L, Komura S. Pre-transplant treatment of hepatocellular carcinoma: Assessment of tumor necrosis in explanted livers. Clin Transplant. 2004;18:227-34.
22. Sieghart W, Fuereder T, Schmid K, et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation. 2007;83:425-32.
23. Yao FY, Kerlan RK Jr, et al.: Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: An intention-to-treat analysis. Hepatology. 2008;48:819-27.