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Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma
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This manuscripts describes the first study, to our knowledge, demonstrating somplete remission in HCC achieved through the use of a a combination chemotheraphy schedule. However, the study demonstrates also that this regimen is poorly manageable and induces severe toxicity in this subset of patients, often characterized by co-morbidities
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Leung TW, Patt YZ, Lau WY, et al. Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res 1999;5:1676-81 •• This manuscripts describes the first study, to our knowledge, demonstrating somplete remission in HCC achieved through the use of a a combination chemotheraphy schedule. However, the study demonstrates also that this regimen is poorly manageable and induces severe toxicity in this subset of patients, often characterized by co-morbidities.
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This manuscript describes the most important clinical trials performed with target-based agents alone or in combination with cytotoxic drugs on HCC paptients
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