Absence of caspase-3 protects pancreatic β-cells from c-Myc-induced apoptosis without leading to tumor formation

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10947-10956

  Radziszewska, Anna ^a   Schroer, Stephanie A ^a   Choi, Diana ^a   Tajmir, Panteha ^a   Radulovich, Nikolina ^a   Ho, James C ^a   Linyuan, Wang ^a   Liadis, Nicole ^a   Hakem, Razqallah ^a   Ming Sound, Tsao ^a   Penn, Linda Z ^a   Evan, Gerard I ^b   Woo, Minna ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC PATHWAYS; APOPTOTIC PROTEINS; CASPASE-3; CELL APOPTOSIS; CELL CYCLE; DISTANT METASTASIS; EXECUTION PHASE; FULL SPECTRUM; IN-VIVO; INDUCED APOPTOSIS; INHIBITORY PROTEINS; KNOCK OUTS; OVER-EXPRESSION; STREPTOZOTOCIN; THERAPEUTIC STRATEGY; TRANSGENE; TRANSGENIC MICE; TUMOR DEVELOPMENT; TUMOR FORMATION; TUMORIGENESIS;

GLUCOSE; TUMORS;

CELL DEATH;

CASPASE 3; MYC PROTEIN; PROTEIN BCL XL; PROTEIN P27; CELL CYCLE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; GENE ACTIVATION; GENE DELETION; GENE OVEREXPRESSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; STREPTOZOCIN DIABETES; TRANSGENE; ANIMAL; CYTOLOGY; ENZYME ACTIVATION; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; MOUSE MUTANT; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY;

MUS; MUS MUSCULUS; RODENTIA;

ANIMALS; APOPTOSIS; CASPASE 3; CELL CYCLE PROTEINS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 67449104524     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806960200     Document Type: Article

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