Gamma-hydroxybutyrate withdrawal syndrome: dangerous but not well-known

General Hospital Psychiatry

Volumn 31, Issue 4, 2009, Pages 394-396

  van Noorden, Martijn S ^a   van Dongen, Lieselotte C A M ^b   Zitman, Frans G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b A )C M   (Netherlands)

Author keywords

Delirium; Gamma hydroxybutyrate; Gamma hydroxybutyric acid; GHB; Withdrawal

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 HYDROXYBUTYRIC ACID; AMPHETAMINE; BICARBONATE; CANNABIS; COCAINE; GLUCOSE; LORAZEPAM; LYSERGIDE; OLANZAPINE; OXAZEPAM; SODIUM CHLORIDE;

ADULT; ANAMNESIS; ARTICLE; AUDITORY HALLUCINATION; CASE REPORT; CONFUSION; DELIRIUM; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HUMAN; MALE; MEMORY DISORDER; RHABDOMYOLYSIS; SCHIZOPHRENIA; SEDATION; SINUS TACHYCARDIA; SOMNOLENCE; SWEATING; TREMOR; VISUAL HALLUCINATION; WITHDRAWAL SYNDROME;

ADOLESCENT; ANTI-ANXIETY AGENTS; DELIRIUM; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; FEMALE; HALF-LIFE; HOSPITALS, GENERAL; HUMANS; LORAZEPAM; MALE; PSYCHIATRY; SODIUM OXYBATE; SUBSTANCE ABUSE DETECTION; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS; TIME FACTORS; YOUNG ADULT;

EID: 67449086586     PISSN: 01638343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2008.11.001     Document Type: Article

References (21)

1. Anderson I.B., Kim S.Y., Dyer J.E., et al. Trends in gamma-hydroxybutyrate (GHB) and related drug intoxication: 1999 to 2003. Ann Emerg Med 47 (2006) 177-183
2. Wu L.T., Schlenger W.E., and Galvin D.M. Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths. Drug Alcohol Depend 84 (2006) 102-113
3. McCambridge J., Winstock A., Hunt N., and Mitcheson L. 5-Year trends in use of hallucinogens and other adjunct drugs among UK dance drug users. Eur Addict Res 13 (2007) 57-64
4. Snead O.C., and Gibson K.M. Drug therapy - gamma-hydroxybutyric acid. N Engl J Med 352 (2005) 2721-2732
5. Dietze P.M., Cvetkovski S., Barratt M.J., and Clemens S. Patterns and incidence of gamma-hydroxybutyrate (GHB)-related ambulance attendances in Melbourne, Victoria. Med J Aust 188 (2008) 709-711
6. Knudsen K., Greter J., and Verdicchio M. High mortality rates among GHB abusers in Western Sweden. Clin Toxicol (Phila) 46 (2008) 187-192
7. Gonzalez A., and Nutt D.J. Gamma hydroxy butyrate abuse and dependency. J Psychopharmacol 19 (2005) 195-204
8. Wong C.G., Chan K.F., Gibson K.M., and Snead O.C. Gamma-hydroxybutyric acid: neurobiology and toxicology of a recreational drug. Toxicol Rev 23 (2004) 3-20
9. McDonough M., Kennedy N., Glasper A., and Bearn J. Clinical features and management of gamma-hydroxybutyrate (GHB) withdrawal: a review. Drug Alcohol Depend 75 (2004) 3-9
10. Wojtowicz J.M., Yarema M.C., and Wax P.M. Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review. CJEM 10 (2008) 69-74
11. Sadock B.J., and Sadock V.A. Kaplan and Sadock's comprehensive textbook of psychiatry (2005), Lippincott, Williams and Wilkins, Philadelphia
12. Levenson J.L. Textbook of psychosomatic medicine (2005), American Psychiatric Publishing, Inc., Washington, DC
13. Rosenberg M.H., Deerfield L.J., and Baruch E.M. Two cases of severe gamma-hydroxybutyrate withdrawal delirium on a psychiatric unit: recommendations for management. Am J Drug Alcohol Abuse 29 (2003) 487-496
14. Mason P.E., and Kerns W.P. Gamma hydroxybutyric acid (GHB) intoxication. Acad Emerg Med 9 (2002) 730-739
15. Dyer J.E., Roth B., and Hyma B.A. Gamma-hydroxybutyrate withdrawal syndrome. Ann Emerg Med 37 (2001) 147-153
16. Fattore L., Cossu G., Martellotta M.C., Deiana S., and Fratta W. Baclofen antagonises intravenous self-administration of gamma-hydroxybutyric acid in mice. Neuroreport 12 (2001) 2243-2246
17. Tarabar A.F., and Nelson L.S. The gamma-hydroxybutyrate withdrawal syndrome. Toxicol Rev 23 (2004) 45-49
18. Craig K., Gomez H.F., McManus J.L., and Bania T.C. Severe gamma-hydroxybutyrate withdrawal: a case report and literature review. J Emerg Med 18 (2000) 65-70
19. Miglani J.S., Kim K.Y., and Chahil R. Gamma-hydroxy butyrate withdrawal delirium: a case report. Gen Hosp Psychiatry 22 (2000) 213-215
20. Bennett W.R.M., Wilson L.G., and Roy-Byrne P.P. Gamma-hydroxybutyric acid (GHB) withdrawal: a case report. J Psychoactive Drugs 39 (2007) 293-296
21. LeTourneau J.L., Hagg D.S., and Smith S.M. Baclofen and gamma-hydroxybutyrate withdrawal. Neurocrit Care 8 (2008) 430-433