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Volumn 18, Issue 3, 2009, Pages 349-358

Review of rifaximin as treatment for SIBO and IBS

Author keywords

Antibiotics; Irritable bowel syndrome; Rifaximin; Small intestinal bacterial overgrowth

Indexed keywords

LEVOFLOXACIN; METRONIDAZOLE; MIDAZOLAM; RIFAXIMIN; RIFAMYCIN;

EID: 67449083400     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543780902780175     Document Type: Review
Times cited : (102)

References (47)
  • 1
    • 18144415878 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Epidemiology, natural history, health care seeking and emerging risk factors
    • DOI 10.1016/j.gtc.2005.02.008
    • Cremonini F, Talley NJ. Irritable bowel syndrome: epidemiology, natural history, health care seeking and emerging risk factors. Gastroenterol Clin North Am 2005;34:189-204 (Pubitemid 40615950)
    • (2005) Gastroenterology Clinics of North America , vol.34 , Issue.2 SPEC. ISS , pp. 189-204
    • Cremonini, F.1    Talley, N.J.2
  • 2
    • 33644834606 scopus 로고    scopus 로고
    • A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation
    • DOI 10.1111/j.1368-5031.2005.00744.x
    • Malagelada JR. A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation. Int J Clin Pract 2006;60:57-63 (Pubitemid 43732577)
    • (2006) International Journal of Clinical Practice , vol.60 , Issue.1 , pp. 57-63
    • Malagelada, J.-R.1
  • 3
    • 20444464327 scopus 로고    scopus 로고
    • Irritable bowel syndrome in the United States: Prevalence, symptom patterns and impact
    • This article is the result of a two-phase community survey and is an in-depth analysis of the status of IBS in the US
    • Hungin APS, Chang L, Locke GR, et al. Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Aliment Pharmacol Ther 2005;21:1365-75 • This article is the result of a two-phase community survey and is an in-depth analysis of the status of IBS in the US.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1365-1375
    • Hungin, A.P.S.1    Chang, L.2    Locke, G.R.3
  • 5
    • 4544314856 scopus 로고    scopus 로고
    • New pathophysiological mechanisms in irritable bowel syndrome
    • This is a description of the varied mechanisms contributing to and interacting in this complex disease state and it gives a basis for why IBS may be so difficult to identify and treat
    • Barbara G, De Giorgio R, Stanghellini V, et al. New pathophysiological mechanisms in irritable bowel syndrome. Aliment Pharmacol Ther 2004;20(Suppl 2):1-9 • This is a description of the varied mechanisms contributing to and interacting in this complex disease state and it gives a basis for why IBS may be so difficult to identify and treat.
    • (2004) Aliment Pharmacol Ther , vol.20 , Issue.SUPPL. 2 , pp. 1-9
    • Barbara, G.1    De Giorgio, R.2    Stanghellini, V.3
  • 6
    • 18144378474 scopus 로고    scopus 로고
    • Efficacy of current drug therapies in irritable bowel syndrome: What works and does not work
    • This work further expands the complexity of treating IBS by describing the many classes of therapies needed to treat multiple symptoms, as well as reviewing the evidence demonstrating efficacy. It also updates the American College of Gastroenterology's comprehensive review of IBS therapies from 2002
    • Schoenfeld P. Efficacy of current drug therapies in irritable bowel syndrome: what works and does not work. Gastroenterol Clin North Am 2005;34:319-35 •• This work further expands the complexity of treating IBS by describing the many classes of therapies needed to treat multiple symptoms, as well as reviewing the evidence demonstrating efficacy. It also updates the American College of Gastroenterology's comprehensive review of IBS therapies from 2002.
    • (2005) Gastroenterol Clin North Am , vol.34 , pp. 319-335
    • Schoenfeld, P.1
  • 7
    • 4243568504 scopus 로고    scopus 로고
    • Research Triangle Park, NC: GlaxoSmithKline
    • Lotronex [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2006
    • (2006) Lotronex [Package Insert]
  • 8
    • 23044499314 scopus 로고    scopus 로고
    • Food and Drug Administration. Available from: Last accessed 10 November 2008
    • FDA public health advisory: tegaserod maleate (marketed as Zelnorm). Food and Drug Administration. Available from: http://www.fda.gov/cder/drug/advisory/ tegaserod.htm [Last accessed 10 November 2008]
    • FDA Public Health Advisory: Tegaserod Maleate (Marketed As Zelnorm)
  • 9
    • 4043116899 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth: A framework for understanding irritable bowel syndrome
    • DOI 10.1001/jama.292.7.852
    • Lin HC. Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 2004;292:852-8 •• This article provides the framework for understanding how SIBO may be a unifying explanation for many of the symptoms related to IBS. (Pubitemid 39079672)
    • (2004) Journal of the American Medical Association , vol.292 , Issue.7 , pp. 852-858
    • Lin, H.C.1
  • 10
    • 0026183504 scopus 로고    scopus 로고
    • Diagnosis of bacterial contamination of the small intestine using the 1g [14C] xylose breath test in various gastrointestinal diseases
    • Galatola G, Grosso M, Barlotta A, et al. Diagnosis of bacterial contamination of the small intestine using the 1g [14C] xylose breath test in various gastrointestinal diseases. Minerva Gastroenterol Dietol 1999;37:169-175
    • (1999) Minerva Gastroenterol Dietol , vol.37 , pp. 169-175
    • Galatola, G.1    Grosso, M.2    Barlotta, A.3
  • 11
    • 0033636668 scopus 로고    scopus 로고
    • Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
    • This article is the first double-blind study to investigate antibiotics in IBS
    • Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 2000;95:3503-6 • This article is the first double-blind study to investigate antibiotics in IBS.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3503-3506
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 12
    • 0037280318 scopus 로고    scopus 로고
    • Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study
    • This study establishes the presence of abnormal lactulose breath test as common in patients with IBS and employs the test following antibiotic therapy to verify improvement in symptoms with eradication of overgrowth
    • Pimentel M, Chow EJ, Lin HC. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 2003;98:412-9 •• This study establishes the presence of abnormal lactulose breath test as common in patients with IBS and employs the test following antibiotic therapy to verify improvement in symptoms with eradication of overgrowth.
    • (2003) Am J Gastroenterol , vol.98 , pp. 412-419
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 13
    • 4043049206 scopus 로고    scopus 로고
    • Sugar intolerance in irritable bowel syndrome: The role of small bowel bacterial overgrowth
    • DDW abstract T1783
    • Nucera G, Lupascu A, Gabrielli M, et al. Sugar intolerance in irritable bowel syndrome: the role of small bowel bacterial overgrowth [DDW abstract T1783]. Gastroenterology 2004;126 (4 suppl 2):A-511
    • (2004) Gastroenterology , vol.126 , Issue.4 SUPPL. 2
    • Nucera, G.1    Lupascu, A.2    Gabrielli, M.3
  • 15
    • 31144455120 scopus 로고    scopus 로고
    • Evaluating the role of small intestinal bacterial overgrowth (SIBO) in diarrhea predominant irritable bowel syndrome (IBS-D) patients utilizing the glucose breath test (GBT)
    • DDW abstract T1118
    • McCallum R, Schultz C, Sostarich S. Evaluating the role of small intestinal bacterial overgrowth (SIBO) in diarrhea predominant irritable bowel syndrome (IBS-D) patients utilizing the glucose breath test (GBT) [DDW abstract T1118]. Gastroenterology 2005;128 (4 suppl 2):A-460
    • (2005) Gastroenterology , vol.128 , Issue.4 SUPPL. 2
    • McCallum, R.1    Schultz, C.2    Sostarich, S.3
  • 16
    • 20444476062 scopus 로고    scopus 로고
    • Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth
    • This study demonstrates that a majority of patients with IBS have underlying SIBO and that eradication of the overgrowth is associated with a reduction of symptoms in a substantial number of those patients
    • Nucera G, Gabrielli M, Lupascu A, et al. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2005;21:1391-5 • This study demonstrates that a majority of patients with IBS have underlying SIBO and that eradication of the overgrowth is associated with a reduction of symptoms in a substantial number of those patients.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1391-1395
    • Nucera, G.1    Gabrielli, M.2    Lupascu, A.3
  • 18
    • 33646359935 scopus 로고    scopus 로고
    • Small intestine bacterial overgrowth in irritable bowel syndrome: A retrospective study with rifaximin
    • Cuoco L, Salvagnini M. Small intestine bacterial overgrowth in irritable bowel syndrome: a retrospective study with rifaximin. Minerva Gastroenterol Dietol 2006;52:89-95 (Pubitemid 43672299)
    • (2006) Minerva Gastroenterologica e Dietologica , vol.52 , Issue.1 , pp. 89-95
    • Cuoco, L.1    Salvagnini, M.2
  • 19
    • 36949031284 scopus 로고    scopus 로고
    • Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: An observation on non-absorbable antibiotics
    • DOI 10.3748/wjg.13.6016
    • Esposito I, de Leone A, Di Gregorio G, et al. Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: an observation on non-absorbable antibiotics. World J Gastroenterol 2007;13:6016-6021 (Pubitemid 350238268)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.45 , pp. 6016-6021
    • Esposito, I.1    De Leone, A.2    Di Gregorio, G.3    Giaquinto, S.4    De Magistris, L.5    Ferrieri, A.6    Riegler, G.7
  • 20
    • 37049019883 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in patients with functional gastrointestinal diseases
    • Madrid AM, Defilippi CC, Defillipi GC, et al. Small intestinal bacterial overgrowth in patients with functional gastrointestinal diseases. Rev Med Chil 2007;135:1245-1252
    • (2007) Rev Med Chil , vol.135 , pp. 1245-1252
    • Madrid, A.M.1    Defilippi, C.C.2    Defillipi, G.C.3
  • 21
    • 39749139596 scopus 로고    scopus 로고
    • Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: Clinical profiles and effects of antibiotic trial
    • Majewski M, McCallum RW. Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: clinical profiles and effects of antibiotic trial. Adv Med Sci 2007;52:139-142
    • (2007) Adv Med Sci , vol.52 , pp. 139-142
    • Majewski, M.1    McCallum, R.W.2
  • 22
    • 48049108263 scopus 로고    scopus 로고
    • Small intestine bacterial overgrowth in patients with irritable bowel syndrome
    • Carrara M, Desideri S, Azzurro M, et al. Small intestine bacterial overgrowth in patients with irritable bowel syndrome. Eur Rev Med Pharmacol Sci 2008;12:197-202
    • (2008) Eur Rev Med Pharmacol Sci , vol.12 , pp. 197-202
    • Carrara, M.1    Desideri, S.2    Azzurro, M.3
  • 23
    • 41849111638 scopus 로고    scopus 로고
    • Lactulose breath testing does not discriminate patients with irritable bowel syndrome from healthy controls
    • Bratten JR, Spanier J, Jones MP. Lactulose breath testing does not discriminate patients with irritable bowel syndrome from healthy controls. Am J Gastroenterol 2008;103:958-963
    • (2008) Am J Gastroenterol , vol.103 , pp. 958-963
    • Bratten, J.R.1    Spanier, J.2    Jones, M.P.3
  • 24
    • 49749090139 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in irritable bowel syndrome: Association with colon motility, bowel symptoms, and psychological distress
    • Grover M, Kanazawa M, Palsson OS, et al. Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress. Neurogastroenterol Motil 2008;20 (9):998-1008
    • (2008) Neurogastroenterol Motil , vol.20 , Issue.9 , pp. 998-1008
    • Grover, M.1    Kanazawa, M.2    Palsson, O.S.3
  • 25
    • 33644502572 scopus 로고    scopus 로고
    • Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic
    • DOI 10.1159/000089776, Bacterial Flora in Digestive Disease
    • Scarpignato C, Pelosini I. Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic. Digestion 2006;73 (suppl 1):13-27 •• This review establishes the attributes of rifaximin as a gastrointestinal selective antibiotic and discusses the role of gastrointestinal bacteria in several gastrointestinal diseases. (Pubitemid 43296214)
    • (2006) Digestion , vol.73 , Issue.SUPPL. 1 , pp. 13-27
    • Scarpignato, C.1    Pelosini, I.2
  • 26
    • 14844331478 scopus 로고    scopus 로고
    • Rifaximin: A nonabsorbed oral antibiotic
    • This article reviews studies that establish the efficacy of rifaximin in treating travelers' diarrhea and discusses how its pharmacokinetics may contribute to potential uses in treating other gastrointestinal disorders
    • Baker DE. Rifaximin: a nonabsorbed oral antibiotic. Rev Gastroenterol Disord 2005;5:19-30 •• This article reviews studies that establish the efficacy of rifaximin in treating travelers' diarrhea and discusses how its pharmacokinetics may contribute to potential uses in treating other gastrointestinal disorders.
    • (2005) Rev Gastroenterol Disord , vol.5 , pp. 19-30
    • Baker, D.E.1
  • 27
    • 67649332531 scopus 로고    scopus 로고
    • Morrisville, NC: Salix Pharmaceuticals, Inc; Prescribing information for rifaximin
    • Xifaxan [package insert]. Morrisville, NC: Salix Pharmaceuticals, Inc; 2008 •• Prescribing information for rifaximin.
    • (2008) Xifaxan [Package Insert]
  • 28
    • 33644549872 scopus 로고    scopus 로고
    • New antibacterial agents in the management of acute infectious diarrhea
    • Available from: [Last accessed 10 November 2008 ] This paper discusses management tactics in utilizing antibacterial agents in the treatment of infectious diarrhea
    • DuPont HL. New antibacterial agents in the management of acute infectious diarrhea. Clin Update Infect Dis 2004;7:1-4. Available from: http://www.nfid.org/pdf/id-archive/acutediarrhea.pdf [Last accessed 10 November 2008 ] • This paper discusses management tactics in utilizing antibacterial agents in the treatment of infectious diarrhea.
    • (2004) Clin Update Infect Dis , vol.7 , pp. 1-4
    • DuPont, H.L.1
  • 29
    • 40549139444 scopus 로고    scopus 로고
    • Systemic pharmacokinetics of rifaximin in volunteers with shigellosis
    • This paper evaluates pharmacokinetic parameters of rifaximin in patients with travelers' diarrhea and supports the minimal serum levels previously demonstrated in healthy volunteers
    • Taylor DN, McKenzie R, Durbin A, et al. Systemic pharmacokinetics of rifaximin in volunteers with shigellosis. Antimicrob Agents Chemother 2008;52:1179-81 •• This paper evaluates pharmacokinetic parameters of rifaximin in patients with travelers' diarrhea and supports the minimal serum levels previously demonstrated in healthy volunteers.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1179-1181
    • Taylor, D.N.1    McKenzie, R.2    Durbin, A.3
  • 31
    • 34948900399 scopus 로고    scopus 로고
    • The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers
    • DOI 10.1592/phco.27.10.1361
    • Pentikis HS, Connolly M, Trapnell CB, et al. The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers. Pharmacother 2007;27:1361-9 •• This study evaluates the potential of rifaximin to inhibit or induce P450 (CYP) enzymes, and the findings support the absence of drug interaction of rifaximin with substrates of intestinal and/or hepatic CYP3A enzymes. (Pubitemid 47530442)
    • (2007) Pharmacotherapy , vol.27 , Issue.10 , pp. 1361-1369
    • Pentikis, H.S.1    Connolly, M.2    Trapnell, C.B.3    Forbes, W.P.4    Bettenhausen, D.K.5
  • 32
    • 33847342947 scopus 로고    scopus 로고
    • Absence of effect of oral rifaximin on the pharmacokinetics of ethinyl estradiol/norgestimate in healthy females
    • DOI 10.1345/aph.1H395
    • Trapnell CB, Connolly M, Pentikis H, et al. Absence of effect of oral rifaximin on the pharmacokinetics of ethinyl estradiol/norgestimate in healthy females. Ann Pharmacother 2007;41:222-228 (Pubitemid 46340052)
    • (2007) Annals of Pharmacotherapy , vol.41 , Issue.2 , pp. 222-228
    • Trapnell, C.B.1    Connolly, M.2    Pentikis, H.3    Forbes, W.P.4    Bettenhausen, D.K.5
  • 33
    • 0033943939 scopus 로고    scopus 로고
    • In vitro activity and fecal concentration of rifaximin after oral administration
    • Jiang ZD, Ke S, Palazzini E, et al. In vitro activity and fecal concentration of rifaximin after oral administration. Antimicrob Agents Chemother 2000;44:2205-2206
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2205-2206
    • Jiang, Z.D.1    Ke, S.2    Palazzini, E.3
  • 34
    • 21744454293 scopus 로고    scopus 로고
    • Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth
    • This study establishes the optimal dose for rifaximin in the treatment of SIBO
    • Lauritano EC, Gabrielli M, Lupascu A, et al. Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2005;22:31-5 • This study establishes the optimal dose for rifaximin in the treatment of SIBO.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 31-35
    • Lauritano, E.C.1    Gabrielli, M.2    Lupascu, A.3
  • 35
    • 34347376566 scopus 로고    scopus 로고
    • A dose-finding study of rifaximin in the treatment of small bowel bacterial overgrowth in patients with irritable bowel syndrome
    • DDW abstract M1174
    • Lauritano EC, Lupascu A, Scarpellini E, et al. A dose-finding study of rifaximin in the treatment of small bowel bacterial overgrowth in patients with irritable bowel syndrome [DDW abstract M1174]. Gastroenterology 2006;130(4 suppl 2):A-317
    • (2006) Gastroenterology , vol.130 , Issue.4 SUPPL. 2
    • Lauritano, E.C.1    Lupascu, A.2    Scarpellini, E.3
  • 37
    • 33750721328 scopus 로고    scopus 로고
    • The effect of a nonabsorbed oral antibiotic (Rifaximin) on the symptoms of the irritable bowel syndrome: A randomized trial
    • Pimentel M, Park S, Mirocha J, et al. The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of irritable bowel syndrome: a randomized trial. Ann Intern Med 2006;145:557-63 •• This study demonstrated that over a 10-week period, rifaximin treatment resulted in greater improvement of IBS symptoms and resulted in a lower bloating score versus placebo. (Pubitemid 46780934)
    • (2006) Annals of Internal Medicine , vol.145 , Issue.8 , pp. 557-563
    • Pimentel, M.1    Park, S.2    Mirocha, J.3    Kane, S.V.4    Kong, Y.5
  • 38
    • 33644912601 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled trial of rifaximin in patients with abdominal bloating and flatulence
    • This study supports the conclusion that rifaximin is a safe and effective treatment for abdominal bloating and flatulence associated with IBS; symptom improvement correlated with reduction in H2-breath excretion
    • Sharara AI, Aoun E, Abdul-Baki H, et al. A randomized double-blind placebo-controlled trial of rifaximin in patients with abdominal bloating and flatulence. Am J Gastroenterol 2006;101:326-33 •• This study supports the conclusion that rifaximin is a safe and effective treatment for abdominal bloating and flatulence associated with IBS; symptom improvement correlated with reduction in H2-breath excretion.
    • (2006) Am J Gastroenterol , vol.101 , pp. 326-333
    • Sharara, A.I.1    Aoun, E.2    Abdul-Baki, H.3
  • 39
    • 37249035165 scopus 로고    scopus 로고
    • Rifaximin versus other antibiotics in the primary treatment and retreatment of bacterial overgrowth in IBS
    • This study demonstrates that rifaximin is more effective than other antibiotics in improving IBS symptoms among patients with abnormal lactulose breath test, even when a patient fails to respond to a previous antibiotic
    • Yang J, Lee HR, Low K, et al. Rifaximin versus other antibiotics in the primary treatment and retreatment of bacterial overgrowth in IBS. Dig Dis Sci 2008;53:169-74 •• This study demonstrates that rifaximin is more effective than other antibiotics in improving IBS symptoms among patients with abnormal lactulose breath test, even when a patient fails to respond to a previous antibiotic.
    • (2008) Dig Dis Sci , vol.53 , pp. 169-174
    • Yang, J.1    Lee, H.R.2    Low, K.3
  • 40
    • 57249089713 scopus 로고    scopus 로고
    • Rifaximin for the treatment of diarrhea-associated irritable bowel syndrome: Short term treatment leading to long term sustained response
    • DDW abstract T1390 This study demonstrates the efficacy of rifaximin as well as sustained results throughout 12 weeks of follow-up
    • Lembo A, Zakko S, Ferreira N, et al. Rifaximin for the treatment of diarrhea-associated irritable bowel syndrome: short term treatment leading to long term sustained response [DDW abstract T1390]. Gastroenterology 2008;134:A-545 •• This study demonstrates the efficacy of rifaximin as well as sustained results throughout 12 weeks of follow-up.
    • (2008) Gastroenterology , vol.134
    • Lembo, A.1    Zakko, S.2    Ferreira, N.3
  • 41
    • 67649368679 scopus 로고    scopus 로고
    • Predictors of clinical response from a phase 2 multi-center efficacy trial using rifaximin, a gut-selective, nonabsorbed antibiotic for the treatment of diarrhea-associated irritable bowel syndrome
    • DDW abstract T1411
    • Ringel Y, Zakko S, Ferreira N, et al. Predictors of clinical response from a phase 2 multi-center efficacy trial using rifaximin, a gut-selective, nonabsorbed antibiotic for the treatment of diarrhea-associated irritable bowel syndrome [DDW abstract T1411]. Gastroenterology 2008;134:A-550
    • (2008) Gastroenterology , vol.134
    • Ringel, Y.1    Zakko, S.2    Ferreira, N.3
  • 42
    • 34347391514 scopus 로고    scopus 로고
    • Rifaximin is effective therapy for small bowel bacterial overgrowth
    • DDW abstract W1732
    • Baidoo L, Kundu R, Berenbaum PL, et al. Rifaximin is effective therapy for small bowel bacterial overgrowth [DDW abstract W1732]. Gastroenterology 2005;128(4 suppl 2):A-672
    • (2005) Gastroenterology , vol.128 , Issue.4 SUPPL. 2
    • Baidoo, L.1    Kundu, R.2    Berenbaum, P.L.3
  • 43
    • 34347397016 scopus 로고    scopus 로고
    • Is rifaximin effective treatment for small intestinal bacterial overgrowth?
    • ACG abstract 293
    • Majewski M, Sostarich S, Foran P, McCallum RW. Is rifaximin effective treatment for small intestinal bacterial overgrowth? [ACG abstract 293]. Am J Gastroenterol 2006;101 (suppl):S141
    • (2006) Am J Gastroenterol , vol.101 , Issue.SUPPL.
    • Majewski, M.1    Sostarich, S.2    Foran, P.3    McCallum, R.W.4
  • 45
    • 35348964647 scopus 로고    scopus 로고
    • Rifaximin versus systemic antibiotics for the treatment of small bowel bacterial overgrowth
    • [DDW abstract S1165]. This study compares rifaximin to systemic antibiotics (metronidazole and levofloxacin) for efficacy, safety and tolerability in the treatment of SIBO. It finds that while rifaximin has similar efficacy compared with systemic antibiotics, it has significantly improved tolerability
    • Gabrielli M, Lauritano C, Scarpellini E, et al. Rifaximin versus systemic antibiotics for the treatment of small bowel bacterial overgrowth [DDW abstract S1165]. Gastroenterology 2007;132 (4 suppl 2):A-187 •• This study compares rifaximin to systemic antibiotics (metronidazole and levofloxacin) for efficacy, safety and tolerability in the treatment of SIBO. It finds that while rifaximin has similar efficacy compared with systemic antibiotics, it has significantly improved tolerability.
    • (2007) Gastroenterology , vol.132 , Issue.4 SUPPL. 2
    • Gabrielli, M.1    Lauritano, C.2    Scarpellini, E.3
  • 46
    • 67649332532 scopus 로고    scopus 로고
    • Available from: Last accessed 10 November 2008
    • Rifaximin 3 times/day for non-constipation IBS (TARGET 2). Available from: http://clinicaltrials.gov/ct2/show/NCT00724126?term=rifaximin&rank=6 [Last accessed 10 November 2008 ]
    • Rifaximin 3 Times/day for Non-constipation IBS (TARGET 2)
  • 47
    • 33745192287 scopus 로고    scopus 로고
    • Current and future developments in travelers' diarrhea therapy
    • DOI 10.1586/14787210.4.3.417
    • Koo HL, DuPont HL. Current and future developments in travelers' diarrhea therapy. Expert Rev Anti Infect Ther 2006;4:417-427 (Pubitemid 43905464)
    • (2006) Expert Review of Anti-Infective Therapy , vol.4 , Issue.3 , pp. 417-427
    • Koo, H.L.1    Dupont, H.L.2


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