Resistance to dermcidin-derived peptides is independent of bacterial protease activity

International Journal of Antimicrobial Agents

Volumn 34, Issue 1, 2009, Pages 86-90

  Senyurek I ^a   Doring G ^a   Kalbacher, H ^a   Deeg, M ^a   Peschel, A ^a   Wolz, C ^a   Schittek, B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Antimicrobial peptides; Dermcidin; LL 37; Proteases

Indexed keywords

BACTERIAL ENZYME; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DERMCIDIN; DERMCIDIN DERIVED PEPTIDE SSL 25; ELASTASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEINASE; SSL 25; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; LASA GENE; LASB GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; WILD TYPE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; GENE DELETION; HUMANS; METALLOENDOPEPTIDASES; MICROBIAL SENSITIVITY TESTS; PEPTIDE HYDROLASES; PEPTIDES; PSEUDOMONAS AERUGINOSA;

EID: 67349282255     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2008.12.008     Document Type: Article

References (15)

1. Schittek B., Hipfel R., Sauer B., Bauer J., Kalbacher H., Stevanovic S., et al. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol 2 (2001) 1133-1137
2. Rieg S., Seeber S., Steffen H., Humeny A., Kalbacher H., Stevanovic S., et al. Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol 126 (2006) 354-365
3. Steffen H., Rieg S., Wiedemann I., Kalbacher H., Deeg M., Sahl H.G., et al. Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge. Antimicrob Agents Chemother 50 (2006) 2608-2620
4. Wolz C., Hellstern E., Haug M., Galloway D.R., Vasil M.L., and Doring G. Pseudomonas aeruginosa LasB mutant constructed by insertional mutagenesis reveals elastolytic activity due to alkaline proteinase and the LasA fragment. Mol Microbiol 5 (1991) 2125-2131
5. Schmidtchen A., Wolff H., and Hansson C. Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers. Acta Derm Venereol 81 (2001) 406-409
6. Horvat R.T., Clabaugh M., Duval-Jobe C., and Parmely M.J. Inactivation of human gamma interferon by Pseudomonas aeruginosa proteases: elastase augments the effects of alkaline protease despite the presence of alpha 2-macroglobulin. Infect Immun 57 (1989) 1668-1674
7. Kessler E., Safrin M., Abrams W.R., Rosenbloom J., and Ohman D.E. Inhibitors and specificity of Pseudomonas aeruginosa LasA. J Biol Chem 272 (1997) 9884-9889
8. Obernesser H.J., Doring G., and Botzenhart K. Extracellular toxins of Pseudomonas aeruginosa. I. Purification and characterization of two exoproteases (author's transl). Zentralbl Bakteriol A 249 (1981) 76-88 [in German]
9. Jagger K.S., Bahner D.R., and Warren R.L. Protease phenotypes of Pseudomonas aeruginosa isolated from patients with cystic fibrosis. J Clin Microbiol 17 (1983) 55-59
10. Ulvatne H., Haukland H.H., Samuelsen O., Kramer M., and Vorland L.H. Proteases in Escherichia coli and Staphylococcus aureus confer reduced susceptibility to lactoferricin B. J Antimicrob Chemother 50 (2002) 461-467
11. Thwaite J.E., Hibbs S., Titball R.W., and Atkins T.P. Proteolytic degradation of human antimicrobial peptide LL-37 by Bacillus anthracis may contribute to virulence. Antimicrob Agents Chemother 50 (2006) 2316-2322
12. Schmidtchen A., Frick I.M., Andersson E., Tapper H., and Bjorck L. Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37. Mol Microbiol 46 (2002) 157-168
13. Sieprawska-Lupa M., Mydel P., Krawczyk K., Wójcik K., Puklo M., Lupa B., et al. Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother 48 (2004) 4673-4679
14. Lai Y., Villaruz A.E., Li M., Cha D.J., Sturdevant D.E., and Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol 63 (2007) 497-506
15. Sagawa K., Kimura A., Saito Y., Inoue H., Yasuda S., Nosaka M., et al. Production and characterization of a monoclonal antibody for sweat-specific protein and its application for sweat identification. Int J Legal Med 117 (2003) 90-95