Why can sensitization by an HLA-DR2 mismatch lead to antibodies that react also with HLA-DR1?

Human Immunology

Volumn 70, Issue 6, 2009, Pages 403-409

  Marrari, Marilyn ^a   Duquesnoy, Rene J ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Allograft nephrectomy; Epitope structure; Eplet; HLA; HLAMatchmaker

Indexed keywords

HLA DR ANTIGEN; HLA DR1 ANTIGEN; HLA DR2 ANTIGEN; HLA DR51 ANTIGEN; UNCLASSIFIED DRUG;

ALGORITHM; ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; ARTICLE; CLINICAL ARTICLE; CROSS ALLERGY; HISTOCOMPATIBILITY; HLA MATCHING; HUMAN; IMMUNOGENICITY; KIDNEY GRAFT REJECTION; PRIORITY JOURNAL;

ALGORITHMS; BLOOD GROUP INCOMPATIBILITY; EPITOPES; GRAFT REJECTION; HISTOCOMPATIBILITY TESTING; HLA-DR1 ANTIGEN; HLA-DR2 ANTIGEN; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION;

EID: 67349280917     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2009.03.005     Document Type: Article

References (23)

1. Duquesnoy R.J. HLAMatchmaker. A molecularly based algorithm for histocompatibility determination. I. Description of the algorithm. Hum Immunol 63 (2002) 339-352
2. Duquesnoy R.J. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 67 (2006) 847-862
3. Adeyi O.E., Girnita A., Awadalla Y., Askar M., Shapiro R., Howe J., et al. Serum analysis after kidney transplant nephrectomy reveals restricted antibody specificity patterns against donor HLA class I antigens. Transpl Immunol 14 (2005) 53-62
4. Duquesnoy R.J., and Claas F.H.J. Progress report of 14th International Histocompatibility Workshop Project on the Structural Basis of HLA Compatibility. Tissue Antigens 69 Suppl 1 (2007) 180-184
5. Duquesnoy R., Mostecki J., Hariharan J., and Balasz I. A structurally based epitope analysis of MICA antibody specificity patterns. Hum Immunol 69 (2008) 826-832
6. Duquesnoy R.J., and Askar M. HLAMatchmaker: A molecularly based algorithm for histocompatibility determination V. Eplet matching for HLA-DR, HLA-DQ and HLA-DP. Hum Immunol 68 (2007) 12-25
7. Duquesnoy R., Awadalla Y., Lomago J., Jelinek L., Howe J., Zern D., et al. Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes. Transpl Immunol 18 (2008) 352-360
8. Cano P., Klitz W., Mack S., Maiers M., Marsh S., Noreen H., et al. Common and well-documented HLA alleles. Report of the Ad-Hoc Committee of the American Society for Histocompatibility and Immunogenetics. Hum Immunol 68 (2007) 392-417
9. Fernandez-Vina M., Moraes J.R., Moraes M.E., Miller S., and Stastny P. HLA class II haplotypes in Amerindians and in black North and South Americans. Tissue Antigens 38 (1991) 235-237
10. Klitz W., Maiers M., Spellman S., Baxter-Lowe L.A., Schmeckpeper B., Williams T.M., et al. New HLA haplotype frequency reference standards: High-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 62 (2003) 296-307
11. Duquesnoy R.J., Mulder A., Askar M., Fernandez-Vina M., and Claas F.H.J. HLAMatchmaker-based analysis of human monoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes. Hum Immunol 66 (2005) 749-761
12. Claas F.H.J., Dankers M.K., Oudshoorn M., van Rood J.J., Mulder A., Roelen D.L., et al. Differential immunogenicity of HLA mismatches in clinical transplantation. Transplant Immunol 14 (2005) 187-191
13. Duquesnoy R.J., Witvliet M.J., Doxiadis I.I.N., de Fijter H., and Claas F.H.J. HLAMatchmaker-based strategy to identify acceptable HLA Class I mismatches for highly sensitized kidney transplant candidates. Transpl Int 7 (2004) 31-38
14. Dankers M.K.A., Witvliet M.D., Roelen D.L., De Lange P., Korfage N., Persijn G.G., et al. The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched HLA antigens. Transplantation I28 (2004) 1236-1239
15. Claas F.H.J., Witvliet M., Duquesnoy R.J., Persijn G., and Doxiadis I.I.N. The acceptable mismatch program as a fast tool to transplant highly sensitized patients awaiting a post-mortal kidney: Short waiting time and excellent graft outcome. Transplantation 78 (2004) 190-193
16. Duquesnoy R.J., and Marrari M. HLAMatchmaker: A Molecularly Based Algorithm For Histocompatibility Determination. II. Verification of the Algorithm and Determination of the Relative Immunogenicity of Amino Acid Triplet-Defined Epitopes. Human Immunology 63 (2002) 353-363
17. Lobashevsky A.L., Senkbeil R.W., Shoaf J.L., Stephenson A.K., Skelton S.B., Burke R.M., et al. The number of amino acid residues mismatches correlates with flow cytometry crossmatching results in high PRA renal patients. Hum Immunol 63 (2002) 364-374
18. Goodman R., Taylor C., O'Rourke C., Lynch A., Bradley A., and Key K. Utility of HLAMatchmaker and single-antigen HLA-antibody detection beads for identification of acceptable mismatches in highly sensitised patients awaiting kidney transplantation. Transplantation 81 (2006) 1331-1336
19. Haririan A., Fagoaga O., Daneshvar H., Morawski K., Sillix D., El-Amm J., et al. Predictive value of HLA epitope matching using HLAMatchmaker for graft outcomes in a predominantly African-American renal transplant cohort. Clin Transplant 20 (2006) 226-233
20. Nambiar A., Duquesnoy R.J., Adams S., Oblitas J., Leitman S., Stroncek D., and Marincola F. HLAMatchmaker-driven analysis of response to HLA matched platelet transfusions in alloimmunized patients. Blood 107 (2006) 1680-1687
21. Valentini R.P., Nehlsen-Cannarella S.L., Gruber S.A., Mattoo T.K., West M.S., Lang C., and Imam A.A. Intravenous immunoglubulin, HLA allele typing and HLAMatchmaker facilitate successful transplantation in highly sensitized pediatric renal allograft recipients. Pediatr Transplant 11 (2007) 77-81
22. Kosmoliaptsis V., Bradley J., Sharples L., Chaudhry A., Key T., Goodman R., and Taylor C. Predicting the immunogenicity of human leukocyte antigen class I alloantigens using structural epitope analysis determined by HLAMatchmaker. Transplantation 85 (2008) 1817-1825
23. Cai J., Kohanof S., and Terasaki P. HLA-DR antibody epitopes. In: Checka M., and Terasaki P.I. (Eds). Clinical transplants 2006 (2006), Tearasaki Foundation Laboratory, Los Angeles, CA 103-114