Structure-activity relationships of a caged thrombin binding DNA aptamer: Insight gained from molecular dynamics simulation studies

Journal of Structural Biology

Volumn 166, Issue 3, 2009, Pages 241-250

  Jayapal, Prabha ^a   Mayer, Günter ^a   Heckel, Alexander ^b   Wennmohs, Frank ^a  

^a UNIVERSITY OF BONN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Thrombin; Caging; Classical molecular dynamic simulation; Hoogsteen hydrogen bonding; Photo labile group; Quadruplex; Thrombin binding aptamer

Indexed keywords

APTAMER; THROMBIN;

ARTICLE; DRUG BINDING; DRUG STABILITY; DRUG STRUCTURE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; STRUCTURE ACTIVITY RELATION;

APTAMERS, NUCLEOTIDE; COMPUTER SIMULATION; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; THERMODYNAMICS;

EID: 67349270534     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2009.01.010     Document Type: Article

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