Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias

Leukemia

Volumn 23, Issue 6, 2009, Pages 1179-1182

  Ballabio, E ^a,b   Cantarella, C D ^c   Federico, C ^c   Di Mare, P ^c   Hall, G ^b   Harbott, J ^d   Hughes, J ^e   Saccone, S ^c   Tosi, S ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CATANIA   (Italy)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; CELL NUCLEUS; CHROMOSOME 12P; CHROMOSOME 7Q; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE; GENE EXPRESSION; GENE FUSION; GENE LOCATION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HLXB9 ETV6 FUSION GENE; HLXB9 GENE; HUMAN; INFANT; MALE; NOM1 GENE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 67349260033     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.15     Document Type: Article

References (8)

1. Tosi S, Hughes J, Biondi A, Scherer SW, Nakabayashi K, Harbott J et al. Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia. Genes Chromosomes Cancer 2003; 38: 191-200.
2. von Bergh AR, van Drunen E, van Wering ER, van Zutven LJ, Hainmann I, Lonnerholm G et al. High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9. Genes Chromosomes Cancer 2006; 45: 731-739.
3. Beverloo HB, Panagopoulos I, Isaksson M, van Wering E, van Drunen E, deKlein A et al. Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7;12)(q36;p13). Cancer Res 2001; 61: 5374-5377.
4. Tosi S, Harbott J, Teigler-schlegel A, Haas OA, Pirc-Danoewinata H, Harrison CJ et al. t(7;12)(q36;p13), a new recurrent translocation involving ETV6 in infant leukemia. Genes Chromosomes Cancer 2000; 29: 325-332.
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8. Federico C, Cantarella CD, Di Mare P, Tosi S, Saccone S. The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density. Chromosoma 2008; 117: 399-410.