Early and Late Presentations of Ethylene Glycol Poisoning

American Journal of Kidney Diseases

Volumn 53, Issue 6, 2009, Pages 1091-1097

  Ting, Stephen M S ^a   Ching, Irene ^a   Nair, Harikrishnan ^a   Langman, Gerald ^a   Suresh, Vijayan ^a   Temple, R Mark ^a  

^a BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

anion gap; Ethylene glycol; osmolal gap; oxalate nephropathy

Indexed keywords

BICARBONATE; C REACTIVE PROTEIN; ETHYLENE GLYCOL; SODIUM CHLORIDE;

ACID BASE BALANCE; ACUTE DISEASE; ADULT; ALCOHOL INTOXICATION; ANAMNESIS; ARTICLE; BODY MASS; CASE REPORT; CLINICAL FEATURE; CRANIAL NERVE PARALYSIS; CREATININE BLOOD LEVEL; ELECTROLYTE BALANCE; ENDOTRACHEAL INTUBATION; ETHYLENE GLYCOL POISONING; GLASGOW COMA SCALE; GLOMERULUS FILTRATION RATE; HEMATURIA; HEMODIALYSIS; HOSPITAL READMISSION; HUMAN; INTENSIVE CARE UNIT; KIDNEY BIOPSY; KIDNEY FUNCTION TEST; KIDNEY INJURY; MALE; METABOLIC ACIDOSIS; OPHTHALMOPLEGIA; PROTEINURIA; SKIN TURGOR; TACHYCARDIA; TORTICOLLIS; UNDERWEIGHT; URINALYSIS;

ACIDOSIS; ACUTE DISEASE; DIAGNOSIS, DIFFERENTIAL; ETHYLENE GLYCOL; HEMOFILTRATION; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; TIME FACTORS;

EID: 67349256776     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.12.019     Document Type: Article

References (36)

1. Baxmann A.C., De O.G., Mendonça C., and Heilberg I.P. Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients. Kidney Int 63 (2003) 1066-1071
2. Danpure C.J. Advances in the enzymology and molecular genetics of primary hyperoxaluria type 1. Prospects for gene therapy. Nephrol Dial Transplant 10 suppl 8 (1995) S24-S29
3. Seargeant L.E., deGroot G.W., Dilling L.A., Mallory C.J., and Haworth J.C. Primary oxaluria type 2 (l-glyceric aciduria): A rare cause of nephrolithiasis in children. J Pediatr 118 (1991) 912-914
4. Nightingale J.M. The short bowel syndrome. Eur J Gastroenterol Hepatol 7 (1995) 514-520
5. McLeod R.S., and Churchill D.N. Urolithiasis complicating inflammatory bowel disease. J Urol 148 (1992) 974-978
6. Mole D., Tomson C., Mortensen N., and Winearls C. Renal complications of jejuno-ileal bypass for obesity. Q J Med 94 (2001) 69-77
7. Barceloux D.G., Krenzelok E.P., Olson K., and Watson W. American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. J Toxicol Clin Toxicol 37 (1999) 537-560
8. Eder A.F., McGrath C.M., Dowdy Y.G., et al. Ethylene glycol poisoning: Toxicokinetic and analytical factors affecting laboratory diagnosis. Clin Chem 44 (1998) 168-177
9. Sivilotti M.L., Burns M.J., McMartin K.E., and Brent J. Toxicokinetics of ethylene glycol during fomepizole therapy: Implications for management. For the Methylpyrazole for Toxic Alcohols Study Group. Ann Emerg Med 36 (2000) 114-125
10. Moreau C.L., Kerns II W., Tomaszewski C.A., et al. Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group. J Toxicol Clin Toxicol 36 (1998) 659-666
11. Jacobsen D., and McMartin K.E. Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical course, diagnosis and treatment. Med Toxicol Adverse Drug Exp 1 (1986) 309-334
12. Hess R., Bartels M.J., and Pottenger L.H. Ethylene glycol: An estimate of tolerable levels of exposure based on a review of animal and human data. Arch Toxicol 78 (2004) 671-680
13. Wacker W.E., Haynes H., Druyan R., Fisher W., and Coleman J.E. Treatment of ethylene glycol poisoning with ethyl alcohol. JAMA 194 (1965) 173-175
14. Ammar K.A., and Heckerling P.S. Ethylene glycol poisoning with normal anion gap caused by concurrent ethanol ingestion: Importance of the osmolal gap. Am J Kidney Dis 27 (1996) 130-133
15. Baud F.J., Galliot M., Astier A., et al. Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. N Engl J Med 319 (1988) 97-100
16. Borron S.W., Mégarbane B., and Baud F.J. Fomepizole in treatment of uncomplicated ethylene glycol poisoning. Lancet 354 (1999) 831
17. Brent J., McMartin K., Phillips S., et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med 340 (1999) 832-838
18. Woo M.Y., Greenway D.C., Nadler S.P., and Cardinal P. Artifactual elevation of lactate in ethylene glycol poisoning. J Emerg Med 25 (2003) 289-293
19. Lindsay S., Akhtar J., Krenzelok E.P., and Brooks D. Artifactual elevation of plasma l-lactate in the presence of glycolate-A potential for misdiagnosis. J Toxicol Clin Toxicol 41 (2003) 476 (abstr)
20. Bachmann E., and Golberg L. Reappraisal of the toxicology of ethylene glycol. III. Mitochondrial effects. Food Cosmet Toxicol 9 (1971) 39-55
21. Gabow B.A., Clay K., Sullivan J.B., and Lepoff R. Organic acids in ethylene glycol intoxication. Ann Intern Med 105 (1986) 16-20
22. Berman L.B., Schreiner G.E., and Feys J. The nephrotoxic lesion of ethylene glycol. Ann Intern Med 46 (1957) 611-619
23. Cruzan G., Corley R.A., Hard G.C., et al. Subchronic toxicity of ethylene glycol in Wistar and F344 rats related to metabolism and clearance of metabolites. Toxicol Sci 81 (2004) 502-511
24. McMartin K.E., and Wallace K.B. Calcium oxalate monohydrate, a metabolite of ethylene glycol, is toxic for rat renal mitochondrial function. Toxicol Sci 84 (2005) 195-200
25. Jacobsen D., Hewlett T.P., Webb R., Brown S.T., Ordinario A.T., and McMartin K.E. Ethylene glycol intoxication: Evaluation of kinetics and crystalluria. Am J Med 84 (1988) 145-152
26. Glasser L., Sternglanz P.D., Combie J., and Robinson A. Serum osmolality and its applicability to drug overdose. Am J Clin Pathol 60 (1973) 695-699
27. Abramson S., and Singh A.K. Treatment of the alcohol intoxications: Ethylene glycol, methanol, isopropanol. Curr Opin Nephrol Hypertens 9 (2000) 695-701
28. Smithline N., and Gardner K.D. Gaps: Anionic and osmolal. JAMA 236 (1976) 1594-1597
29. Mallya K.B., Mendis T., and Guberman A. Bilateral facial paralysis following ethylene glycol ingestion. Can J Neurol Sci 13 (1986) 340-341
30. Factor S.A., and Lava N.S. Ethylene glycol intoxication: A new stage in the clinical syndrome. NY State J Med 87 (1987) 189-190
31. Berger J.R., and Ayyar R.A. Neurological complications of ethylene glycol intoxication. Report of a case. Arch Neurol 38 (1981) 724-726
32. Lewis L.D., Smith B.W., and Mamourian A.C. Delayed sequelae after acute overdoses or poisonings: Cranial neuropathy related to ethylene glycol ingestion. Clin Pharmacol Ther 61 (1997) 692-699
33. Palmer B.F., Eigenbrodt E.H., and Henrich W.L. Cranial nerve deficit: A clue to the diagnosis of ethylene glycol poisoning. Am J Med 87 (1989) 91-92
34. Spillane L., Roberts J.R., and Meyer A.E. Multiple cranial nerve deficits after ethylene glycol poisoning. Ann Emerg Med 20 (1991) 208-210
35. Anderson B., and Adams M. Facial-auditory nerve oxalosis. Am J Med 88 (1990) 87-88 (letter)
36. Fellman D.M. Facial diplegia following ethylene glycol. Arch Neurol 39 (1982) 739-740