Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species

Phytomedicine

Volumn 16, Issue 6-7, 2009, Pages 659-664

  Abdel Sattar, Essam ^a   Shehab, Naglaa G ^b   Ichino, Chikara ^c   Kiyohara, Hiroaki ^c   Ishiyama, Aki ^c   Otoguro, Kazuhiko ^c   Omura, Satoshi ^c   Yamada, Haruki ^c  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b CAIRO UNIVERSITY   (Egypt)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

Antitrypanosomal activity; Asclepiadaceae; Caralluma penicillata; Caralluma russelliana; Caralluma tuberculata; Caratubersides; Cytotoxicity; Penicillosides; Russeliosides

Indexed keywords

CARATUBERSIDE C; CARATUBERSIDE D; CARATUBERSIDE E; CARATUBERSIDE F; CARATUBERSIDE G; EFLORNITHINE; GLYCOSIDE; MELARSOPROL; PENICILLOSIDE A; PENICILLOSIDE B; PENICILLOSIDE C; PENICILLOSIDE D; PENICILLOSIDE E; PENICILLOSIDE F; PENICILLOSIDE G; PENTAMIDINE; PREGNANE DERIVATIVE; RUSSELIOSIDE B; RUSSELIOSIDE C; RUSSELIOSIDE D; RUSSELIOSIDE E; SURAMIN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; ASCLEPIADACEAE; CARALLUMA PENICILLATA; CARALLUMA RUSSELLIANA; CARALLUMA TUBERCULATA; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; GLYCOSYLATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ACYLATION; ANIMALS; ASCLEPIADACEAE; CARBOHYDRATE SEQUENCE; CELL LINE; GLYCOSIDES; GLYCOSYLATION; HUMANS; MOLECULAR SEQUENCE DATA; PREGNANES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

APOCYNACEAE; CARALLUMA; PENICILLATA; RUSSELLIANA;

EID: 67349250377     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.02.009     Document Type: Article

References (23)

1. Abdel-Sattar E., Al-Yahya M.A., Nakamura N., and Hatori M. Penicillosides A-C, C-15 Oxypregnane glycosides from Caralluma penicillata. Phytochemistry 57 (2001) 1213-1217
2. Abdel-Sattar E., Harraz F.M.H., Al-ansari S.M.A., El-Mekkawy S., Ichino C., and Kiyohara H. Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity. Phytochemistry 69 (2008) 2180-2186
3. Abdel-Sattar E., Meselhy M.R., and Al-Yahya M.A. New oxypregnane glycosides from Caralluma penicillata. Planta Med. 68 (2002) 430-434
4. Ahmed V.U., Usmanghani K., and Rizwani G.H. J. Nat. Prod. 51 (1988) 1092-1097
5. Al-Yahya M.A., Abdel-Sattar E., and Guittet E. Pregnane glycosides from Caralluma russe-liana. J. Nat. Prod. 63 (2000) 1451-1453
6. Barrett M.P. The fall and rise of sleeping sickness. Lancet 353 (1999) 1113-1114
7. Camacho M.D.R., Croft S.L., and Phillipson J.D. Natural products as sources of antiprotozoal drugs. Curr. Opin. Antiinfect. Invest. Drugs 2 (2000) 47-62
8. Deepak D., Khare A., and Khare M.P. Plant Pregnanes Phytochem. 28 (1989) 3255-3263
9. Deepak D., Srivastav S., and Khare A. Pregnane glycosides. Prog. Chem. Organ. Prod. 71 (1997) 169-325
10. Evans W.C. Trease and Evans, Pharmacognosy. 15th ed (2002), W.B Saunders company, London, Toronto, Sydney
11. Kayser O., Kinderlen A.F., and Croft S.L. Natural product as antiparasitic drugs. Parasitol. Res. 90 (2003) S55-S62
12. Lin L.-J., Lin L.-Z., Gil R.R., Cordell G.A., Ramesh M., Srilatha B., et al. Pregnane glycosides from Caralluma umbellata. Phytochemistry 35 (1994) 1549-1553
13. Mackey Z.B., Baca A.M., Mallari J.B., Apsel B., Shelat A., Hansell E.J., Chiang P.K., Wolff B., Guy K.R., Williams J., and McKerrow J.H. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem. Biol. Drug Des. 67 (2006) 355-363
14. Mossman T. Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
15. Neuwinger H.D. African Ethnobotany: Poisons and Drugs (1994), Chapman & Hall, New York pp. 238-239
16. Otoguro K., Komiyama K., Omura S., and Tyson C.A. An in vitro cytotoxicity assay using rat hepatocytes and MTT and coomassie blue dye as indicators. ATLA 19 (1991) 352-360
17. Pepin J., and Milord F. The treatment of human African trypanosomiasis. Adv. Parasitol. 33 (1994) 1-47
18. Qiu S.-X., Cordell G.A., Kumar B.R., Rao Y.N., Ramesh M., and Kokate C. Studies on the C-21 steroids from asclepiadaceous plants bisdesmosidic pregnane glycosides from Caralluma lasiantha. Phytochemistry 50 (1999) 485-491
19. ® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro. Acta Trop. 68 (1997) 139-147
20. Tagboto S., and Townson S. Antiparasitic properties of medicinal plants and other natural occurring products. Adv. Parasitol. 50 (2001) 199-295
21. Tanaka T., Tsukamoto S., and Hayashi K. Pregnane glycosides from Boucerosia aucherian. Phytochemistry 29 (1990) 229-237
22. WHO, 1998. Control and surveillance of African trypanosomiasis. Report of a WHO Expert Committee. World Health Organization Technical Report Series 881, vol. I-VI, pp. 1-114.
23. Yabu Y., Koide T., Ohta N., Nose M., and Ogihara Y. Continuous growth of bloodstream forms of Trypanosoma brucei brucei in an axenic culture system containing a low concentration of serum. Southeast Asian J. Trop. Med. Public Health 29 (1998) 591-595