Translocation t(14;18) is not associated with inferior outcome in chronic lymphocytic leukemia

Leukemia

Volumn 23, Issue 6, 2009, Pages 1201-1204

  Put, N ^a   Meeus, P ^a,b   Chatelain, B ^c   Rack, K ^d   Boeckx, N ^e   Nollet, F ^f   Graux, C ^c   Van Den Neste, E ^g   Janssens, A ^e   Madoe, V ^h   Van Hoof, A ^f   Bilhou Nabera, C ⁱ   Wlodarska, I ^a   Vandenberghe, P ^a   Michaux, L ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b OLV HOSPITAL   (Belgium)

^c UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^d Institut de Pathologie   (Belgium)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f General Hospital St Jan   (Belgium)

^g CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^h Salvator Hospital   (Belgium)

ⁱ Lab d'Hématologie Biologique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CHLORAMBUCIL; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUDARABINE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PREDNIMUSTINE; PREDNISONE; PROTEIN BCL 2; PROTEIN KINASE ZAP 70; PROTEIN P53; TENIPOSIDE; VINCRISTINE;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER STAGING; CHROMOSOME ANALYSIS; CHROMOSOME DELETION 13; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 18; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DISEASE ASSOCIATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOPHENOTYPING; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE; TRISOMY 12;

EID: 67349248527     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.44     Document Type: Article

References (8)

1. Van Den Neste E, Robin V, Francart J, Hagemeijer A, Stul M, Vandenberghe P et al. Chromosomal translocations independently predict treatment failure, treatment-free survival and overall survival in B-cell chronic lymphocytic leukemia patients treated with cladribine. Leukemia 2007; 21: 1715-1722.
2. Mayr C, Speicher MR, Kofler DM, Buhmann R, Strehl J, Busch R et al Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood 2006; 107: 742-751.
3. Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 1990; 323: 720-724.
4. Nowakowski GS, Smoley S, Schwager S, Zent CS, Call TG, Shanafelt TD et al. Presence of immunoglobulin heavy chain gene (IGH) translocations in chronic lymphocytic leukemia is related to poor prognosis. ASH Annual Meeting Abstracts. Blood 2007; 110: 2067.
5. Nowakowski GS, Dewald GW, Hoyer JD, Paternoster SF, Stockero KJ, Fink SR et al. Interphase fluorescence in situ hybridization with an IGH probe is important in the evaluation of patients with a clinical diagnosis of chronic lymphocytic leukaemia. Br J Haematol 2005; 130: 36-42.
6. Cavazzini F, Hernandez JA, Gozzetti A, Russo Rossi A, De Angeli C, Tiseo R et al. Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis. Br J Haematol 2008; 142: 529-536.
7. Van Bockstaele F, Verhasselt B, Philippe J. Prognostic markers in chronic lymphocytic leukemia: A comprehensive review. Blood Rev 2009; 23: 25-47.
8. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.