Antibiotic prophylaxis is not protective in severe acute pancreatitis: a systematic review and meta-analysis

American Journal of Surgery

Volumn 197, Issue 6, 2009, Pages 806-813

  Jafri, Nadim S ^a   Mahid, Suhal S ^a   Idstein, Spencer R ^a   Hornung, Carlton A ^a   Galandiuk, Susan ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Antibiotic prophylaxis; Meta analysis; Pancreatitis; RCTs; Severe acute pancreatitis

Indexed keywords

BETA LACTAM; CEFUROXIME; CEPHALOSPORIN; CIPROFLOXACIN; IMIPENEM; MEROPENEM; METRONIDAZOLE; OFLOXACIN; PLACEBO; QUINOLONE;

ACUTE PANCREATITIS; ANTIBIOTIC PROPHYLAXIS; CALCULATION; CELL HETEROGENEITY; CLINICAL TRIAL; COCHRANE LIBRARY; DISEASE SEVERITY; EMBASE; HUMAN; LENGTH OF STAY; MEDLINE; META ANALYSIS; MORTALITY; NECROSIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; RISK REDUCTION; SENSITIVITY ANALYSIS; SURGICAL TECHNIQUE; SYSTEMATIC REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; HUMANS; PANCREATITIS, ACUTE NECROTIZING; SEVERITY OF ILLNESS INDEX;

EID: 67349239979     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2008.08.016     Document Type: Review

References (38)

1. Russo M.W., Wei J.T., Thiny M.T., et al. Digestive and liver diseases statistics. Gastroenterology 126 (2004) 1448-1453
2. Bradley III E.L. A clinically based classification system for acute pancreatitis. Summary of the international symposium on acute pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg 128 (1993) 586-590
3. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 13 (1985) 818-829
4. Dervenis C., Johnson C.D., Bassi C., et al. Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. Int J Pancreatol 25 (1999) 195-210
5. Uhl W., Warshaw A., Imrie C., et al. IAP Guidelines for the Surgical management of acute pancreatitis. Pancreatology 2 (2002) 565-573
6. Mazaki T., Ishii Y., and Takayama T. Meta-analysis of prophylactic antibiotic use in acute necrotizing pancreatitis. Br J Surg 93 (2006) 674-684
7. Howes R., Zuidema G.D., and Cameron J.L. Evaluation of prophylactic antibiotics in acute pancreatitis. J Surg Res 18 (1975) 197-200
8. Runkel N.S., Moody F.G., Smith G.S., et al. The role of the gut in the development of sepsis in acute pancreatitis. J Surg Res 51 (1991) 18-23
9. Bai Y., Gao J., Zou D.W., et al. Prophylactic antibiotics cannot reduce infected pancreatic necrosis and mortality in acute necrotizing pancreatitis: evidence from a meta-analysis of randomized controlled trials. Am J Gastroenterol 103 (2008) 104-110
10. Bassi C., Larvin M., and Villatoro E. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev 4 (2003) CD002941
11. De Vries A.C., Besselink M.G., Buskens E., et al. Randomized controlled trials of antibiotic prophylaxis in severe acute pancreatitis: relationship between methodological quality and outcome. Pancreatology 7 (2007) 531-538
12. Golub R., Siddiqi F., and Pohl D. Role of antibiotics in acute pancreatitis: a meta-analysis. J Gastrointest Surg 2 (1998) 496-503
13. Heinrich S., Schafer M., Rousson V., et al. Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann Surg 243 (2006) 154-168
14. Sharma V.K., and Howden C.W. Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: a meta-analysis. Pancreas 22 (2001) 28-31
15. Villatoro E., Bassi C., and Larvin M. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev 4 (2006) CD002941
16. Jadad A.R., Moore R.A., Carroll D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 17 (1996) 1-12
17. Moher D., Cook D.J., Eastwood S., et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses. Lancet 354 (1999) 1896-1900
18. Bero L., Rennie D., and The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care. JAMA 274 (1995) 1935-1938
19. Mantel N., and Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22 (1959) 719-748
20. Yusuf S., Peto R., Lewis J., et al. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 27 (1985) 335-371
21. Cochran W.G. The combination of estimates from different experiments. Biometrics 10 (1954) 101-129
22. Higgins J.P., Thompson S.G., Deeks J.J., et al. Measuring inconsistency in meta-analyses. BMJ 327 (2003) 557-560
23. Antman E.M., Lau J., Kupelnick B., et al. A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction. JAMA 268 (1992) 240-248
24. Sackett D.L., Straus S.E., and Richardson W.S. Evidence Based Medicine: How to Practice and Teach EBM (2000), Churchill Livingstone, Edinburgh
25. Egger M., Davey S.G., Schneider M., et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997) 629-634
26. Begg C.B., and Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 50 (1994) 1088-1101
27. Dellinger E.P., Tellado J.M., Soto N.E., et al. Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg 245 (2007) 674-683
28. Isenmann R., Runzi M., Kron M., et al. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology 126 (2004) 997-1004
29. Nordback I., Sand J., Saaristo R., et al. Early treatment with antibiotics reduces the need for surgery in acute necrotizing pancreatitis-a single-center randomized study. J Gastrointest Surg 5 (2001) 113-118
30. Pederzoli P., Bassi C., Vesentini S., et al. A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 176 (1993) 480-483
31. Rokke O., Harbitz T.B., Liljedal J., et al. Early treatment of severe pancreatitis with imipenem: a prospective randomized clinical trial. Scand J Gastroenterol 42 (2007) 771-776
32. Sainio V., Kemppainen E., Puolakkainen P., et al. Early antibiotic treatment in acute necrotising pancreatitis. Lancet 346 (1995) 663-667
33. Schwarz M., Isenmann R., Meyer H., et al. Antibiotic use in necrotizing pancreatitis. Results of a controlled study. Dtsch Med Wochenschr 122 (1997) 356-361
34. Spicak J., Hejtmankova S., Cech P., et al. Antibiotic prophylaxis in large pancreatic necrosis: multicenter randomized trial with ciprofloxacin and metronidazole or meropenem. Gastroenterology 126 (2004) A-229
35. UK guidelines for the management of acute pancreatitis. Gut 54 (2005) iii1-iii9
36. Wyncoll D.L. The management of severe acute necrotising pancreatitis: an evidence-based review of the literature. Intensive Care Med 25 (1999) 146-156
37. Gotzinger P., Wamser P., Barlan M., et al. Candida infection of local necrosis in severe acute pancreatitis is associated with increased mortality. Shock 14 (2000) 320-323
38. Isenmann R., Schwarz M., Rau B., et al. Characteristics of infection with Candida species in patients with necrotizing pancreatitis. World J Surg 26 (2002) 372-376