Simultaneous versus sequential optimal design for pharmacokinetic- pharmacodynamic models with FO and FOCE considerations

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 36, Issue 2, 2009, Pages 101-123

  McGree, J M ^a   Eccleston, J A ^a   Duffull, S B ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

D optimality; Discrete response; FO and FOCE approximations; Nested multiple response models; Product design optimality; Simultaneous versus sequential design

Indexed keywords

AREA UNDER THE CURVE; ARTICLE; ASSAY; MATHEMATICAL ANALYSIS; MATHEMATICAL PARAMETERS; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; SEQUENTIAL ANALYSIS; SIMULATION; STATISTICAL MODEL;

MODELS, BIOLOGICAL; MODELS, STATISTICAL; PHARMACOKINETICS; RESEARCH DESIGN;

EID: 67349235121     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-009-9113-0     Document Type: Article

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