A reappraisal on the ability of leptin to induce fever

Physiology and Behavior

Volumn 97, Issue 3-4, 2009, Pages 430-436

  Steiner, Alexandre A ^a,b   Krall, Catherine M ^a,b   Liu, Elaine ^a  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b STRATTON VA MEDICAL CENTER   (United States)

Author keywords

Adipose tissue; Body temperature; Cytokines; Fever; Inflammation; Leptin

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG EFFECT; DRUG FEVER; FEEDING BEHAVIOR; FOOD DEPRIVATION; HYPOTHERMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPERATURE MEASUREMENT;

ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; FEVER; FOOD DEPRIVATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LEPTIN; MALE; RATS; RATS, WISTAR; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67349232452     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2009.03.018     Document Type: Article

References (68)

1. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
2. Elmquist J.K., Maratos-Flier E., Saper C.B., and Flier J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1 (1998) 445-450
3. Ahima R.S., and Flier J.S. Leptin. Annu Rev Physiol 62 (2000) 413-437
4. Havel P.J. Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53 (2004) S143-S151
5. de Luca C., Kowalski T.J., Zhang Y., Elmquist J.K., Lee C., Kilimann M.W., et al. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115 (2005) 3484-3493
6. Coppari R., Ichinose M., Lee C.E., Pullen A.E., Kenny C.D., McGovern R.A., et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 1 (2005) 63-72
7. Scarpace P.J., Matheny M., Zhang Y., Cheng K.Y., and Tumer N. Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance. J Pharmacol Exp Ther 320 (2007) 706-712
8. Peters J.H., Simasko S.M., and Ritter R.C. Leptin analog antagonizes leptin effects on food intake and body weight but mimics leptin-induced vagal afferent activation. Endocrinology 148 (2007) 2878-2885
9. Bingham N.C., Anderson K.K., Reuter A.L., Stallings N.R., and Parker K.L. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149 (2008) 2138-2148
10. Doring H., Schwarzer K., Nuesslein-Hildesheim B., and Schmidt I. Leptin selectively increases energy expenditure of food-restricted lean mice. Int J Obes Relat Metab Disord 22 (1998) 83-88
11. Gavrilova O., Leon L.R., Marcus-Samuels B., Mason M.M., Castle A.L., Refetoff S., et al. Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 96 (1999) 14623-14628
12. Rosenbaum M., Murphy E.M., Heymsfield S.B., Matthews D.E., and Leibel R.L. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87 (2002) 2391-2394
13. Freeman D.A., Lewis D.A., Kauffman A.S., Blum R.M., and Dark J. Reduced leptin concentrations are permissive for display of torpor in Siberian hamsters. Am J Physiol Regul Integr Comp Physiol 287 (2004) R97-R103
14. Montez J.M., Soukas A., Asilmaz E., Fayzikhodjaeva G., Fantuzzi G., and Friedman J.M. Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci U S A 102 (2005) 2537-2542
15. Faggioni R., Feingold K.R., and Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 15 (2001) 2565-2571
16. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115 (2005) 911-919
17. Steiner A.A., and Romanovsky A.A. Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res 46 (2007) 89-107
18. Luheshi G.N., and Rummel C. Is programming of weight regulation immune to neonatal inflammation?. Am J Physiol Regul Integr Comp Physiol 293 (2007) R578-R580
19. Bartfai T., Sanchez-Alavez M., Andell-Jonsson S., Schultzberg M., Vezzani A., Danielsson E., et al. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Ann N Y Acad Sci 1113 (2007) 173-177
20. Fabricio A.S., Tringali G., Pozzoli G., Melo M.C., Vercesi J.A., Souza G.E., et al. Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats. Am J Physiol Regul Integr Comp Physiol 290 (2006) R1515-R1523
21. Pittman Q.J. Endothelin-an emerging role in proinflammatory pathways in brain. Am J Physiol Regul Integr Comp Physiol 290 (2006) R162-R163
22. Luheshi G.N., Gardner J.D., Rushforth D.A., Loudon A.S., and Rothwell N.J. Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci U S A 96 (1999) 7047-7052
23. Turek V.F. The effects of melanocortin agonists and antagonists on leptin-induced fever in rats. J Therm Biol 29 (2004) 423-430
24. Kelly J.F., Elias C.F., Lee C.E., Ahima R.S., Seeley R.J., Bjorbaek C., et al. Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes 53 (2004) 911-920
25. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1 (1995) 1155-1161
26. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334 (1996) 292-295
27. 2 triggers the febrile response of guinea pigs to intravenously injected LPS. Am J Physiol Regul Integr Comp Physiol 290 (2006) R1262-R1270
28. Bibby D.C., and Grimble R.F. Temperature and metabolic changes in rats after various doses of tumour necrosis factor α. J Physiol 410 (1989) 367-380
29. Nagai M., Saigusa T., Shimada Y., Inagawa H., Oshima H., and Iriki M. Antibody to tumor necrosis factor (TNF) reduces endotoxin fever. Experientia 44 (1988) 606-607
30. Roth J., Martin D., Storr B., and Zeisberger E. Neutralization of pyrogen-induced tumour necrosis factor by its type 1 soluble receptor in guinea-pigs: effects on fever and interleukin-6 release. J Physiol 509 (1998) 267-275
31. Leon L.R. Cytokine regulation of fever: studies using gene knockout mice. J Appl Physiol 92 (2002) 2648-2655
32. Ogawa Y., Masuzaki H., Isse N., Okazaki T., Mori K., Shigemoto M., et al. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest 96 (1995) 1647-1652
33. Muller G., Ertl J., Gerl M., and Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272 (1997) 10585-10593
34. Haynes W.G., Morgan D.A., Walsh S.A., Mark A.L., and Sivitz W.I. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100 (1997) 270-278
35. McCowen K.C., Chow J.C., and Smith R.J. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 139 (1998) 4442-4447
36. 1A receptors in raphe pallidus inhibits leptin-evoked increases in brown adipose tissue thermogenesis. Am J Physiol Regul Integr Comp Physiol 286 (2004) R832-R837
37. Wang L.C. Modulation of maximum thermogenesis by feeding in the white rat. J Appl Physiol 49 (1980) 975-978
38. Steiner A.A., Dogan M.D., Ivanov A.I., Patel S., Rudaya A.Y., Jennings D.H., et al. A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. FASEB J 18 (2004) 1949-1951
39. Romanovsky A.A., Almeida M.C., Aronoff D.M., Ivanov A.I., Konsman J.P., Steiner A.A., et al. Fever and hypothermia in systemic inflammation: recent discoveries and revisions. Front Biosci 10 (2005) 2193-2216
40. Blumberg M.S., Deaver K., and Kirby R.F. Leptin disinhibits nonshivering thermogenesis in infants after maternal separation. Am J Physiol 276 (1999) R606-R610
41. Kluger M.J. Fever: role of pyrogens and cryogens. Physiol Rev 71 (1991) 93-127
42. Sindelar D.K., Havel P.J., Seeley R.J., Wilkinson C.W., Woods S.C., and Schwartz M.W. Low plasma leptin levels contribute to diabetic hyperphagia in rats. Diabetes 48 (1999) 1275-1280
43. Wang T., Hartzell D.L., Rose B.S., Flatt W.P., Hulsey M.G., Menon N.K., et al. Metabolic responses to intracerebroventricular leptin and restricted feeding. Physiol Behav 65 (1999) 839-848
44. Johnson J.D., O'Connor K.A., Hansen M.K., Watkins L.R., and Maier S.F. Effects of prior stress on LPS-induced cytokine and sickness responses. Am J Physiol Regul Integr Comp Physiol 284 (2003) R422-R432
45. Loffreda S., Yang S.Q., Lin H.Z., Karp C.L., Brengman M.L., Wang D.J., et al. Leptin regulates proinflammatory immune responses. FASEB J 12 (1998) 57-65
46. Zarkesh-Esfahani H., Pockley G., Metcalfe R.A., Bidlingmaier M., Wu Z., Ajami A., et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 167 (2001) 4593-4599
47. Wong C.K., Cheung P.F., and Lam C.W. Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur J Immunol 37 (2007) 2337-2348
48. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
49. Mastronardi C.A., Yu W.H., Rettori V., and McCann S. Lipopolysaccharide-induced leptin release is not mediated by nitric oxide, but is blocked by dexamethasone. Neuroimmunomodulation 8 (2000) 91-97
50. Mastronardi C.A., Srivastava V., Yu W.H., Les Dees W., and McCann S.M. Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone. Neuroimmunomodulation 12 (2005) 182-188
51. Bik W., Wolinska-Witort E., Chmielowska M., Rusiecka-Kuczalek E., and Baranowska B. Does leptin modulate immune and endocrine response in the time of LPS-induced acute inflammation?. Neuro Endocrinol Lett 22 (2001) 208-214
52. Faggioni R., Fuller J., Moser A., Feingold K.R., and Grunfeld C. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am J Physiol 273 (1997) R181-R186
53. Faggioni R., Fantuzzi G., Gabay C., Moser A., Dinarello C.A., Feingold K.R., et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276 (1999) R136-R142
54. Mancuso P., Gottschalk A., Phare S.M., Peters-Golden M., Lukacs N.W., and Huffnagle G.B. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 168 (2002) 4018-4024
55. O'Connor J.C., Satpathy A., Hartman M.E., Horvath E.M., Kelley K.W., Dantzer R., et al. IL-1β-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J Immunol 174 (2005) 4991-4997
56. Ivanov A.I., and Romanovsky A.A. Fever responses of Zucker rats with and without fatty mutation of the leptin receptor. Am J Physiol Regul Integr Comp Physiol 282 (2002) R311-R316
57. Niimi M., Sato M., Yokote R., Tada S., and Takahara J. Effects of central and peripheral injection of leptin on food intake and on brain Fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinaemia. J Neuroendocrinol 11 (1999) 605-611
58. Ivanov A.I., Kulchitsky V.A., and Romanovsky A.A. Does obesity affect febrile responsiveness?. Int J Obes Relat Metab Disord 25 (2001) 586-589
59. Ivanov A.I., Kulchitsky V.A., and Romanovsky A.A. Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis. J Physiol 547 (2003) 941-949
60. Rummel C., Inoue W., Sachot C., Poole S., Hubschle T., and Luheshi G.N. Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice. J Comp Neurol 511 (2008) 373-395
61. Sachot C., Poole S., and Luheshi G.N. Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats. J Physiol 561 (2004) 263-272
62. Harden L.M., du Plessis I., Poole S., and Laburn H.P. Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior. Physiol Behav 89 (2006) 146-155
63. Gordon C.J. Thermal biology of the laboratory rat. Physiol Behav 47 (1990) 963-991
64. Romanovsky A.A., Ivanov A.I., and Shimansky Y.P. Ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J Appl Physiol 92 (2002) 2667-2679
65. Szekely M., and Romanovsky A.A. Pyretic and antipyretic signals within and without fever: a possible interplay. Med Hypotheses 50 (1998) 213-218
66. Romanovsky A.A. Do fever and anapyrexia exist? Analysis of set point-based definitions. Am J Physiol Regul Integr Comp Physiol 287 (2004) R992-R995
67. Pini M., Sennello J.A., Chan L., and Fantuzzi G. Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice. Endocrinology 147 (2006) 5019-5022
68. Teoh H., Quan A., Bang K.W., Wang G., Lovren F., Vu V., et al. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab 295 (2008) E658-E664