Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome

Journal of Critical Care

Volumn 24, Issue 2, 2009, Pages 236-242

  Medford, Andrew R L ^a   Ibrahim, Nassif B N ^b   Millar, Ann B ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b FRENCHAY HOSPITAL   (United Kingdom)

Author keywords

Acute respiratory distress syndrome; Receptors; Vascular endothelial growth factor, Neuropilin

Indexed keywords

NEUROPILIN 1; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CONTROLLED STUDY; DENSITOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG PARENCHYMA; PROTEIN EXPRESSION; RESPIRATORY DISTRESS; UPREGULATION;

HUMANS; LUNG; NEUROPILIN-1; PULMONARY ALVEOLI; RESPIRATORY DISTRESS SYNDROME, ADULT; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 67349226442     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2008.04.003     Document Type: Article

References (33)

1. Ware L.B., and Matthay M.A. The acute respiratory distress syndrome. N Engl J Med 342 18 (2000) 1334-1349
2. Carmeliet P., Ferreira V., Breier G., et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380 6573 (1996) 435-439
3. Thickett D.R., Armstrong L., Christie S.J., et al. Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome. Am J Respir Crit Care Med 164 9 (2001) 1601-1605
4. Thickett D.R., Armstrong L., and Millar A.B. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med 166 10 (2002) 1332-1337
5. Medford A.R., Keen L.J., Bidwell J.L., et al. Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome. Thorax 60 3 (2005) 244-248
6. Medford A.R., and Millar A.B. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?. Thorax 61 7 (2006) 621-626
7. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342 18 (2000) 1301-1308
8. Maitre B., Boussat S., Jean D., et al. Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury. Eur Respir J 18 1 (2001) 100-106
9. Kaner R.J., and Crystal R.G. Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med 7 4 (2001) 240-246
10. Armstrong L., Medford A.R., Thorley A., et al. Primary human alveolar epithelial type II cells constitutively produce vascular endothelial growth factor. Am J Respir Crit Care Med 165 (2002) A372
11. Terman B.I., Carrion M.E., Kovacs E., et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6 9 (1991) 1677-1683
12. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
13. Soker S., Fidder H., Neufeld G., et al. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J Biol Chem 271 10 (1996) 5761-5767
14. Matsumoto T., and Claesson-Welsh L. VEGF receptor signal transduction. Trends Biochem Sci 2003 (2003) 488-494
15. Fong G.H., Rossant J., Gertsenstein M., et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376 6535 (1995) 66-70
16. Brown K.R., England K.M., Goss K.L., et al. VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol Lung Cell Mol Physiol 281 4 (2001) L1001-L1010
17. Fehrenbach H., Haase M., Kasper M., et al. Alterations in the immunohistochemical distribution patterns of vascular endothelial growth factor receptors Flk1 and Flt1 in bleomycin-induced rat lung fibrosis. Virchows Arch 435 1 (1999) 20-31
18. Klekamp J.G., Jarzecka K., and Perkett E.A. Exposure to hyperoxia decreases the expression of vascular endothelial growth factor and its receptors in adult rat lungs. Am J Pathol 154 3 (1999) 823-831
19. Tuder R.M., Flook B.E., and Voelkel N.F. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J Clin Invest 95 4 (1995) 1798-1807
20. Gerber H.P., Condorelli F., Park J., et al. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 272 38 (1997) 23659-23667
21. Shen B.Q., Lee D.Y., Gerber H.P., et al. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro. J Biol Chem 273 45 (1998) 29979-29985
22. Barleon B., Siemeister G., Martiny-Baron G., et al. Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. Cancer Res 57 23 (1997) 5421-5425
23. Perkins G.D., Roberts J., McAuley D.F., et al. Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury. Thorax 60 2 (2005) 153-158
24. Foster R.R., Hole R., Anderson K., et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol 284 6 (2003) F1263-F1273
25. Lassus P., Turanlahti M., Heikkila P., et al. Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 164 10 Pt 1 (2001) 1981-1987
26. Tsokos M., Pufe T., Paulsen F., et al. Pulmonary expression of vascular endothelial growth factor in sepsis. Arch Pathol Lab Med 127 3 (2003) 331-335
27. Kasahara Y., Tuder R.M., Taraseviciene-Stewart L., et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 106 11 (2000) 1311-1319
28. Ito Y., Betsuyaku T., Nagai K., et al. Expression of pulmonary VEGF family declines with age and is further down-regulated in lipopolysaccharide (LPS)-induced lung injury. Exp Gerontol 40 4 (2005) 315-323
29. Mura M., Han B., Andrade C.F., et al. The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival. Crit Care 10 5 (2006) R130
30. Tambunting F., Beharry K.D., Waltzman J., et al. Impaired lung vascular endothelial growth factor in extremely premature baboons developing bronchopulmonary dysplasia/chronic lung disease. J Investig Med 53 5 (2005) 253-262
31. Maniscalco W.M., Watkins R.H., Pryhuber G.S., et al. Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons. Am J Physiol Lung Cell Mol Physiol 282 4 (2002) L811-L823
32. Gurkan O.U., O'Donnell C., Brower R., et al. Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol 285 3 (2003) L710-L718
33. Kazi A.A., Lee W.S., Wagner E., et al. VEGF, fetal liver kinase-1, and permeability increase during unilateral lung ischemia. Am J Physiol Lung Cell Mol Physiol 279 3 (2000) L460-L467