Primary skeletal muscle cells trigger spontaneous Toxoplasma gondii tachyzoite-to-bradyzoite conversion at higher rates than fibroblasts

International Journal of Medical Microbiology

Volumn 299, Issue 5, 2009, Pages 381-388

  Ferreira da Silva, Marialice da Fonseca ^a,b   Takács, Anna C ^a   Barbosa, Helene S ^b   Gross, Uwe ^a   Lüder, Carsten G K ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Bradyzoite; Parasite persistence; Skeletal muscle cell; Stage conversion; Toxoplasma gondii

Indexed keywords

MYOD PROTEIN; MYOGENIC FACTOR 5;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRADYZOITE; CELL DIFFERENTIATION; CELL DIVISION; CELL LABELING; CELL TYPE; CELL VACUOLE; CONTROLLED STUDY; EMBRYO; EXPERIMENTAL INFECTION; FIBROBLAST; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOUSE; MUSCLE CELL; MUSCLE CONTRACTILITY; MYOBLAST; MYOTUBE; NONHUMAN; PARASITE VIRULENCE; SKELETAL MUSCLE; TACHYZOITE; TOXOPLASMA GONDII;

ANIMALS; CELLS, CULTURED; FIBROBLASTS; MICE; MUSCLE CELLS; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; TOXOPLASMA;

EID: 67349224994     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2008.10.002     Document Type: Article

References (26)

1. Barbosa, H.S., Pereira, M.C.S., Meirelles, M.N.L., 2000. Protocolos de culturas primárias. In: Araújo-Jorge, T., de Castro, S.L., Doenca de Chagas (Eds.), Manual para experimentação animal. Fiocruz, Rio de Janeiro, pp. 297-313.
2. Bohne W., Heesemann J., and Gross U. Coexistence of heterogeneous populations of Toxoplasma gondii parasites within parasitophorous vacuoles of murine macrophages as revealed by a bradyzoite-specific monoclonal antibody. Parasitol. Res. 79 (1993) 485-487
3. Bohne W., Heesemann J., and Gross U. Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion. Infect. Immun. 62 (1994) 1761-1767
4. Brown C.R., and McLeod R. Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection. J. Immunol. 145 (1990) 3438-3441
5. Chai Z., Sarcevic B., Mawson A., and Toh B.-H. SET-related cell division antoantigen-1 (CDA1) arrests cell growth. J. Biol. Chem. 276 (2001) 33665-33674
6. Dobrowolski J.M., and Sibley L.D. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 84 (1996) 933-939
7. Dubey J.P., Lindsay D.S., and Speer C.A. Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts. Clin. Microbiol. Rev. 11 (1998) 267-299
8. Dzierszinski F., Mortuaire M., Dendouga N., Popescu O., and Tomavo S. Differential expression of two plant-like enolases with distinct enzymatic and antigenic properties during stage conversion of the protozoan parasite Toxoplasma gondii. J. Mol. Biol. 309 (2001) 1017-1027
9. Ferguson D.J.P. Use of molecular and ultrastructural markers to evaluate stage conversion of Toxoplasma gondii in both the intermediate and definitive host. Int. J. Parasitol. 34 (2004) 347-360
10. Ferguson D.J.P., and Hutchinson W.M. An ultrastructural study of the early development and tissue cyst formation of Toxoplasma gondii in the brains of mice. Parasitol. Res. 73 (1987) 723-734
11. Ferreira da Silva M.d.F., Barbosa H.S., Groß U., and Lüder C.G.K. Stress-related and spontaneous stage differentiation of Toxoplasma gondii. Mol. BioSyst. 4 (2008) 824-834
12. Fox B.A., Gigley J.P., and Bzik D.J. Toxoplasma gondii lacks the enzyme required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. Int. J. Parasitol. 34 (2004) 323-331
13. Gross U., Bormuth H., Gaissmaier C., Dittrich C., Krenn V., Bohne W., and Ferguson D.J. Monoclonal rat antibodies directed against Toxoplasma gondii suitable for studying tachyzoite-bradyzoite interconversion in vivo. Clin. Diagn. Lab. Immunol. 2 (1995) 542-548
14. Guimarães E.V., Carvalho L., and Barbosa H.S. Primary culture of skeletal muscle cells as a model for studies of Toxoplasma gondii cystogenesis. J. Parasitol. 94 (2008) 72-83
15. Montoya J.G., and Liesenfeld O. Toxoplasmosis. Lancet 363 (2004) 1965-1976
16. ®) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30 (2002) e36
17. Radke J.R., Donald R.G., Eibs A., Jerome M.E., Behnke M.S., Liberator P., and White M.W. Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development. PLOS Pathog. 2 (2006) e105
18. Sabourin L.A., and Rudnicki M.A. The molecular regulation of myogenesis. Clin. Genet. 57 (2000) 16-25
19. Soête M., Fortier B., Camus D., and Dubremetz J.F. Toxoplasma gondii: kinetics of bradyzoite-tachyzoite interconversion in vitro. Exp. Parasitol. 76 (1993) 259-264
20. Soête M., Camus D., and Dubremetz J.F. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro. Exp. Parasitol. 78 (1994) 361-370
21. Streilein J.W. Unraveling immune privilege. Science 270 (1995) 1158-1159
22. Tajbakhsh S., Rocancourt D., Cossu G., and Buckingham M. Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD. Cell 89 (1997) 127-138
23. Tenter A.M., Heckeroth A.R., and Weiss L.M. Toxoplasma gondii: from animals to humans. Int. J. Parasitol. 30 (2000) 1217-1258
24. Tomavo S., and Weiss L.M. Toxoplasma gene regulation and bradyzoite development. In: Ajioka J.W., and Soldati D. (Eds). Toxoplasma. Molecular and Cellular Biology (2007), Horizon Bioscience, Norfolk 285-301
25. Waf/Cip1 by activating p53 and MEK/ERK1/2 MAPK pathways. J. Biol. Chem. 282 (2007) 11722-11731
26. Wiendl H., Hohlfeld R., and Kieseier B.C. Immunobiology of muscle: advances in understanding an immunological microenvironment. Trends Immunol. 26 (2005) 373-380