Expression and localization of the Parkin Co-Regulated Gene in mouse CNS suggests a role in ependymal cilia function

Neuroscience Letters

Volumn 460, Issue 1, 2009, Pages 97-101

  Wilson, Gabrielle R ^a,b   Tan, Jacqueline T ^a   Brody, Kate M ^a   Taylor, Juliet M ^a   Delatycki, Martin B ^a,b   Lockhart, Paul J ^a,b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Ependymal cilia; Expression; In situ hybridization; Localization; Mouse brain; Parkin Co Regulated Gene

Indexed keywords

PARKIN; PARKIN CO REGULATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN AQUEDUCT; BRAIN FOURTH VENTRICLE; BRAIN THIRD VENTRICLE; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; EPENDYMA CELL; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LATERAL BRAIN VENTRICLE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CEREBRAL VENTRICLES; CILIA; EPENDYMA; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; MICE, INBRED C57BL; PROTEINS;

EID: 67349222832     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.05.043     Document Type: Article

References (21)

1. Brody K.M., Taylor J.M., Wilson G.R., Delatycki M.B., and Lockhart P.J. Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain. Brain Res. 1201 (2008) 177-186
2. Dawe H.R., Farr H., and Gull K. Centriole/basal body morphogenesis and migration during ciliogenesis in animal cells. J. Cell Sci. 120 (2007) 7-15
3. Dawe H.R., Farr H., Portman N., Shaw M.K., and Gull K. The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis. J. Cell Sci. 118 (2005) 5421-5430
4. Didier M., Harandi M., Aguera M., Bancel B., Tardy M., Fages C., Calas A., Stagaard M., Mollgard K., and Belin M.F. Differential immunocytochemical staining for glial fibrillary acidic (GFA) protein, S-100 protein and glutamine synthetase in the rat subcommissural organ, nonspecialized ventricular ependyma and adjacent neuropil. Cell Tissue Res. 245 (1986) 343-351
5. Ikeda T. Parkin-co-regulated gene (PACRG) product interacts with tubulin and microtubules. FEBS Lett. 582 (2008) 1413-1418
6. Ikeda K., Ikeda T., Morikawa K., and Kamiya R. Axonemal localization of Chlamydomonas PACRG, a homologue of the human Parkin-coregulated gene product. Cell Motil. Cytoskeleton 64 (2007) 814-821
7. Imai Y., Soda M., Murakami T., Shoji M., Abe K., and Takahashi R. A product of the human gene adjacent to Parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J. Biol. Chem. 278 (2003) 51901-51910
8. Keller L.C., Romijn E.P., Zamora I., Yates III J.R., and Marshall W.F. Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr. Biol. 15 (2005) 1090-1098
9. Kilburn C.L., Pearson C.G., Romijn E.P., Meehl J.B., Giddings III T.H., Culver B.P., Yates Jr. J.R., and Winey M. New Tetrahymena basal body protein components identify basal body domain structure. J. Cell Biol. 178 (2007) 905-912
10. Lockhart P.J., O'Farrell C.A., and Farrer M.J. It's a double knock-out! The quaking mouse is a spontaneous deletion of Parkin and Parkin co-regulated gene (PACRG). Mov. Disord. 19 (2004) 101-104
11. Lorenzetti D., Bishop C.E., and Justice M.J. Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 8402-8407
12. Paxinos G., and Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates, vol. 1. compact 2nd ed. (2004), Elsevier Academic Press
13. Piperno G., LeDizet M., and Chang X.J. Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J. Cell Biol. 104 (1987) 289-302
14. Schlossmacher M.G., Frosch M.P., Gai W.P., Medina M., Sharma N., Forno L., Ochiishi T., Shimura H., Sharon R., Hattori N., Langston J.W., Mizuno Y., Hyman B.T., Selkoe D.J., and Kosik K.S. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am. J. Pathol. 160 (2002) 1655-1667
15. Sidman R.L., Dickie M.M., and Appel S.H. Mutant mice (Quaking and Jimpy) with deficient myelination in the central nervous system. Science 144 (1964) 309-311
16. Solano S.M., Miller D.W., Augood S.J., Young A.B., and Penney Jr. J.B. Expression of alpha-synuclein, Parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease. Ann. Neurol. 47 (2000) 201-210
17. Spassky N., Merkle F.T., Flames N., Tramontin A.D., Garcia-Verdugo J.M., and Alvarez-Buylla A. Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. J. Neurosci. 25 (2005) 10-18
18. Stichel C.C., Augustin M., Kuhn K., Zhu X.R., Engels P., Ullmer C., and Lubbert H. Parkin expression in the adult mouse brain. Eur. J. Neurosci. 12 (2000) 4181-4194
19. Taylor J.M., Song Y.J., Huang Y., Farrer M.J., Delatycki M.B., Halliday G.M., and Lockhart P.J. Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases. Neurobiol. Dis. 27 (2007) 238-247
20. J.M. Taylor, R.M. Wu, M.J. Farrer, M.B. Delatycki, P.J. Lockhart, Analysis of Parkin co-regulated gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease, Parkinsonism Relat. Disord. (2009). In press, doi:10.1016/j.parkreldis.2008.11.009.
21. West A.B., Lockhart P.J., O'Farell C., and Farrer M.J. Identification of a novel gene linked to Parkin via a bi-directional promoter. J. Mol. Biol. 326 (2003) 11-19